Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 1, 2024
Abstract
Background
Endoscopic
submucosal
dissection
(ESD)
is
the
current
standard
treatment
for
early-stage
esophageal
neoplasms.
However,
postoperative
stricture
after
extensive
mucosal
remains
a
severe
challenge
with
limited
effective
treatments
available.
In
this
study,
we
introduced
chitosan/gelatin
(ChGel)
sponge
encapsulating
adipose
mesenchymal
stem
cells
(ADMSCs)-derived
exosomes
(ChGel
MSC−Exo
)
prevention
of
stenosis
ESD
in
porcine
model.
Results
Pigs
were
randomly
assigned
into
(1)
ChGel
group,
(2)
PBS
and
(3)
controls.
Exosome
applied
immediately
on
day
as
well
7.
components
crucial
wound
healing
investigated
by
liquid
chromatography-tandem
mass
spectrometry
(LC–MS/MS)
small
RNA
sequencing.
significantly
reduced
contraction
21,
less
fiber
accumulation
inflammatory
infiltration,
enhanced
angiogenesis
when
compared
control
groups.
The
anti-fibrotic
effects
following
MSC-Exo
further
found
to
be
associated
anti-inflammatory
M2
polarization
resident
macrophages,
especially
within
M2b
subset
characterized
TGFβ1
secretion,
which
sufficiently
inhibited
inflammation
prevented
activation
myofibroblast
collagen
production
at
early
stage
ESD.
Moreover,
abundant
expression
exosomal
MFGE8
was
identified
involved
transition
M2b-macrophage
through
MFGE8/STAT3/Arg1
axis.
Conclusions
Our
study
demonstrates
that
promotes
subset,
consequently
reducing
deposition.
These
findings
suggest
promising
potential
therapy
preventing
development
near-circumferential
Graphical
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 22, 2023
Abstract
Macrophages
exist
in
various
tissues,
several
body
cavities,
and
around
mucosal
surfaces
are
a
vital
part
of
the
innate
immune
system
for
host
defense
against
many
pathogens
cancers.
possess
binary
M1/M2
macrophage
polarization
settings,
which
perform
central
role
an
array
tasks
via
intrinsic
signal
cascades
and,
therefore,
must
be
precisely
regulated.
Many
crucial
questions
about
signaling
modulation
yet
to
uncovered.
In
addition,
clinical
importance
tumor-associated
macrophages
is
becoming
more
widely
recognized
as
significant
progress
has
been
made
understanding
their
biology.
Moreover,
they
integral
tumor
microenvironment,
playing
regulation
wide
variety
processes
including
angiogenesis,
extracellular
matrix
transformation,
cancer
cell
proliferation,
metastasis,
immunosuppression,
resistance
chemotherapeutic
checkpoint
blockade
immunotherapies.
Herein,
we
discuss
signaling,
mechanical
stresses
modulation,
metabolic
pathways,
mitochondrial
transcriptional,
epigenetic
regulation.
Furthermore,
have
broadly
extended
traps
essential
roles
autophagy
aging
regulating
functions.
discussed
recent
advances
macrophages-mediated
autoimmune
diseases
tumorigenesis.
Lastly,
targeted
therapy
portray
prospective
targets
therapeutic
strategies
health
diseases.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 27, 2023
Abstract
Psoriasis
is
a
common,
chronic,
and
inflammatory
skin
disease
with
high
burden
on
individuals,
health
systems,
society
worldwide.
With
the
immunological
pathologies
pathogenesis
of
psoriasis
becoming
gradually
revealed,
therapeutic
approaches
for
this
have
gained
revolutionary
progress.
Nevertheless,
mechanisms
less
common
forms
remain
elusive.
Furthermore,
severe
adverse
effects
recurrence
upon
treatment
cessation
should
be
noted
addressed
during
treatment,
which,
however,
has
been
rarely
explored
integration
preliminary
findings.
Therefore,
it
crucial
to
comprehensive
understanding
behind
pathogenesis,
which
might
offer
new
insights
research
lead
more
substantive
progress
in
expand
clinical
options
treatment.
In
review,
we
looked
briefly
introduce
epidemiology,
subtypes,
pathophysiology,
comorbidities
systematically
discuss
signaling
pathways
involving
extracellular
cytokines
intracellular
transmission,
as
well
cross-talk
between
them.
discussion,
also
paid
attention
potential
metabolic
epigenetic
molecular
mechanistic
cascades
related
its
comorbidities.
This
review
outlined
current
psoriasis,
especially
targeted
therapies
novel
strategies,
mechanism
recurrence.
Annual Review of Physiology,
Год журнала:
2024,
Номер
86(1), С. 225 - 253
Опубликована: Фев. 12, 2024
Exosomes
are
small
extracellular
vesicles
that
carry
lipids,
proteins,
and
microRNAs
(miRNAs).
They
released
by
all
cell
types
can
be
found
not
only
in
circulation
but
many
biological
fluids.
essential
for
interorgan
communication
because
they
transfer
their
contents
from
donor
to
recipient
cells,
modulating
cellular
functions.
The
miRNA
content
of
exosomes
is
responsible
most
effects,
changes
exosomal
levels
contribute
the
progression
or
regression
metabolic
diseases.
As
miRNAs
selectively
sorted
packaged
into
exosomes,
useful
as
biomarkers
diagnosing
field
metabolism
expanding
rapidly,
researchers
consistently
making
new
discoveries
this
area.
a
result,
have
great
potential
next-generation
drug
delivery
platform
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Апрель 22, 2024
Abstract
Sepsis,
a
severe
systemic
inflammatory
response
to
infection,
remains
leading
cause
of
morbidity
and
mortality
worldwide.
Exosomes,
as
mediators
intercellular
communication,
play
pivotal
role
in
the
pathogenesis
sepsis
through
modulating
immune
responses,
metabolic
reprogramming,
coagulopathy,
organ
dysfunction.
This
review
highlights
emerging
significance
exosomes
these
processes.
Initially,
it
provides
an
in-depth
insight
into
exosome
biogenesis
characterization,
laying
groundwork
for
understanding
their
diverse
intricate
functions.
Subsequently,
explores
regulatory
roles
various
cells
such
neutrophils,
macrophages,
dendritic
cells,
T
B
cells.
analysis
elucidates
how
are
thus
contributing
complexity
pathophysiology.
Additionally,
this
delves
regulation
metabolism
subsequent
dysfunction
sepsis.
It
also
establishes
connection
between
coagulation
cascade,
which
affects
endothelial
integrity
promotes
thrombogenesis
Moreover,
discusses
dual
progression
resolution
sepsis,
exploring
complex
involvement
inflammation
healing
Furthermore,
underscores
potential
biomarkers
therapeutic
targets.
Understanding
mechanisms
presents
new
opportunities
novel
interventions
mitigate
outcomes
emphasizing
promise
research
critical
care
settings.
Artificial Cells Nanomedicine and Biotechnology,
Год журнала:
2024,
Номер
52(1), С. 355 - 369
Опубликована: Июнь 4, 2024
The
global
epidemic
of
metabolic
diseases
has
led
to
the
emergence
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
steatohepatitis
(MASH),
which
pose
a
significant
threat
human
health.
Despite
recent
advances
in
research
on
pathogenesis
treatment
MASLD/MASH,
there
is
still
lack
more
effective
targeted
therapies.
Extracellular
vesicles
(EVs)
discovered
wide
range
tissues
body
fluids
encapsulate
different
activated
biomolecules
mediate
intercellular
communication.
Recent
studies
have
shown
that
EVs
derived
from
adipose
tissue
(AT)
play
vital
roles
MASLD/MASH
therapeutics,
depending
their
sources
intervention
types.
Besides,
adipose-derived
stem
cell
(ADSC)-derived
appear
be
mitigating
MASLD/MASH.
This
review
presents
an
overview
definition,
extraction
strategies,
characterisation
EVs,
with
particular
focus
biogenesis
release
exosomes.
It
also
reviews
effects
potential
molecular
mechanisms
liver-
AT-derived
emphasises
contribution
clinical
therapeutic
ADSC-derived
EVs.
Furthermore,
future
perspective
EV
therapy
setting
discussed.
