eLife assessment: Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Опубликована: Май 17, 2023

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding gene-by-environment interactions underlying inflammation IBD. Here, profiled colon transcriptome 52 BXD mouse strains fed with chow or high-fat diet (HFD) identified subset that exhibit an IBD-like signature on HFD, indicating interplay genetics significantly affect intestinal inflammation. Using gene co-expression analyses, modules are enriched for IBD-dysregulated genes found these IBD-related share cis-regulatory elements responsive to STAT2, SMAD3, REL transcription We used module quantitative trait locus (ModQTL) analyses identify loci associated expression modules. Through prioritization scheme involving systems in integration external human datasets, Muc4 Epha6 as top candidates mediating differences HFD-driven This work provides insights into contribution risk identifies two candidate genes, MUC4 EPHA6, may mediate susceptibility humans.

Язык: Английский

---

eLife assessment: Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Опубликована: Май 17, 2023

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding gene-by-environment interactions underlying inflammation IBD. Here, profiled colon transcriptome 52 BXD mouse strains fed with chow or high-fat diet (HFD) identified subset that exhibit an IBD-like signature on HFD, indicating interplay genetics significantly affect intestinal inflammation. Using gene co-expression analyses, modules are enriched for IBD-dysregulated genes found these IBD-related share cis-regulatory elements responsive to STAT2, SMAD3, REL transcription We used module quantitative trait locus (ModQTL) analyses identify loci associated expression modules. Through prioritization scheme involving systems in integration external human datasets, Muc4 Epha6 as top candidates mediating differences HFD-driven This work provides insights into contribution risk identifies two candidate genes, MUC4 EPHA6, may mediate susceptibility humans.

Язык: Английский

---

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Опубликована: Июль 4, 2023

Abstract Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding gene-by-environment interactions underlying inflammation IBD. Here, profiled colon transcriptome 52 BXD mouse strains fed with chow or high-fat diet (HFD) identified subset that exhibit an IBD-like signature on HFD, indicating interplay genetics significantly affect intestinal inflammation. Using gene co-expression analyses, modules are enriched for IBD-dysregulated genes found these IBD-related share cis-regulatory elements responsive to STAT2, SMAD3, REL transcription We used module quantitative trait locus (ModQTL) analyses identify loci associated expression modules. Through prioritization scheme involving systems in integration external human datasets, Muc4 Epha6 as top candidates mediating differences HFD-driven This work provides insights into contribution risk identifies two candidate genes, MUC4 EPHA6, may mediate susceptibility humans.

Язык: Английский

---

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

eLife, Год журнала: 2023, Номер 12

Опубликована: Окт. 19, 2023

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding gene-by-environment interactions underlying inflammation IBD. Here, profiled colon transcriptome 52 BXD mouse strains fed with chow or high-fat diet (HFD) identified subset that exhibit an IBD-like signature on HFD, indicating interplay genetics significantly affect intestinal inflammation. Using gene co-expression analyses, modules are enriched for IBD-dysregulated genes found these IBD-related share cis -regulatory elements responsive to STAT2, SMAD3 , REL transcription We used module quantitative trait locus analyses identify loci associated expression modules. Through prioritization scheme involving systems in integration external human datasets, Muc4 Epha6 as top candidates mediating differences HFD-driven This work provides insights into contribution risk identifies two candidate genes, MUC4 EPHA6 may mediate susceptibility humans.

Язык: Английский

---