Adipose
tissue
undergoes
changes
with
aging,
leading
to
increased
adiposity,
inflammatory
cell
infiltration,
reduced
angiogenesis,
heightened
oxidative
stress,
and
alterations
in
its
metabolic
function.
Regular
exercise
has
been
recognized
as
a
powerful
intervention
that
can
positively
influence
adipose
health
mitigate
the
effects
of
aging.
However,
molecular
mechanisms
underlying
benefits
regular
on
aging
function
remain
poorly
understood.
Adipokines
released
through
play
potential
role
mitigating
enhancing
metabolism
glucose
lipids,
reducing
inflammation
fibrosis,
promoting
fat
browning
thermogenesis.
The
goal
this
review
is
offer
comprehensive
overview
addressing
age-related
decline
significance
disorders
associated
aged
will
be
discussed.
Diagnostics,
Год журнала:
2025,
Номер
15(3), С. 327 - 327
Опубликована: Янв. 30, 2025
Wearable
devices
have
gained
increasing
attention
for
use
in
multifunctional
applications
related
to
health
monitoring,
particularly
research
of
the
circadian
rhythms
cognitive
functions
and
metabolic
processes.
In
this
comprehensive
review,
we
encompass
how
wearables
can
be
used
study
disease.
We
highlight
importance
these
as
markers
well-being
potential
predictors
outcomes.
focus
on
wearable
technologies
sleep
research,
medicine,
chronomedicine
beyond
domain
emphasize
actigraphy
a
validated
tool
monitoring
sleep,
activity,
light
exposure.
discuss
various
mathematical
methods
currently
analyze
actigraphic
data,
such
parametric
non-parametric
approaches,
linear,
non-linear,
neural
network-based
applied
quantify
non-circadian
variability.
also
introduce
novel
actigraphy-derived
markers,
which
personalized
proxies
status,
assisting
discriminating
between
disease,
offering
insights
into
neurobehavioral
status.
lifestyle
factors
physical
activity
exposure
modulate
brain
health.
establishing
reference
standards
measures
further
refine
data
interpretation
improve
clinical
The
review
calls
existing
tools
methods,
deepen
our
understanding
health,
develop
healthcare
strategies.
Science Immunology,
Год журнала:
2023,
Номер
8(89)
Опубликована: Ноя. 3, 2023
Exercise
enhances
physical
performance
and
reduces
the
risk
of
many
disorders
such
as
cardiovascular
disease,
type
2
diabetes,
dementia,
cancer.
characteristically
incites
an
inflammatory
response,
notably
in
skeletal
muscles.
Although
some
effector
mechanisms
have
been
identified,
regulatory
elements
activated
response
to
exercise
remain
obscure.
Here,
we
addressed
roles
Foxp3
+
CD4
T
cells
(T
regs
)
healthful
activities
via
immunologic,
transcriptomic,
histologic,
metabolic,
biochemical
analyses
acute
chronic
models
mice.
rapidly
induced
expansion
muscle
reg
compartment,
thereby
guarding
against
overexuberant
production
interferon-γ
consequent
metabolic
disruptions,
particularly
mitochondrial
aberrancies.
The
performance-enhancing
effects
training
were
dampened
absence
.
Thus,
is
a
natural
booster
with
therapeutic
potential
disease
aging
contexts.
Nature Metabolism,
Год журнала:
2023,
Номер
5(11), С. 2020 - 2035
Опубликована: Сен. 11, 2023
Abstract
Skeletal
muscle
has
an
enormous
plastic
potential
to
adapt
various
external
and
internal
perturbations.
Although
morphological
changes
in
endurance-trained
muscles
are
well
described,
the
molecular
underpinnings
of
training
adaptation
poorly
understood.
We
therefore
aimed
elucidate
signature
trained
male
mice
unravel
status-dependent
responses
acute
bout
exercise.
Our
results
reveal
that,
even
though
at
baseline
unexpectedly
low
number
genes
define
muscle,
status
substantially
affects
transcriptional
response
challenge,
both
quantitatively
qualitatively,
part
associated
with
epigenetic
modifications.
Finally,
transiently
activated
factors
such
as
peroxisome
proliferator-activated
receptor-γ
coactivator
1α
indispensable
for
normal
adaptation.
Together,
these
provide
a
framework
temporal
exercise
that
underpins
plasticity
training.
Regular
exercise
leads
to
widespread
salutary
effects,
and
there
is
increasing
recognition
that
exercise-stimulated
circulating
proteins
can
impart
health
benefits.
Despite
this,
limited
data
exist
regarding
the
plasma
proteomic
changes
occur
in
response
regular
exercise.
Here,
we
perform
large-scale
profiling
654
healthy
human
study
participants
before
after
a
supervised,
20-week
endurance
training
intervention.
We
identify
hundreds
of
are
modulated,
many
which
known
be
secreted.
highlight
involved
angiogenesis,
iron
homeostasis,
extracellular
matrix,
novel,
including
training-induced
increases
fibroblast
activation
protein
(FAP),
membrane-bound
relevant
body-composition
homeostasis.
relate
maximal
oxygen
uptake
adaptations
validate
our
top
findings
an
external
cohort.
Furthermore,
show
FAP
positively
associated
with
survival
3
separate,
population-based
cohorts.
Cell Reports,
Год журнала:
2023,
Номер
42(4), С. 112392 - 112392
Опубликована: Апрель 1, 2023
Inguinal
white
adipose
tissue
(iWAT)
is
essential
for
the
beneficial
effects
of
exercise
training
on
metabolic
health.
The
underlying
mechanisms
these
are
not
fully
understood,
and
here,
we
test
hypothesis
that
results
in
a
more
favorable
iWAT
structural
phenotype.
Using
biochemical,
imaging,
multi-omics
analyses,
find
11
days
wheel
running
male
mice
causes
profound
remodeling
including
decreased
extracellular
matrix
(ECM)
deposition
increased
vascularization
innervation.
We
identify
stem
cells
as
one
main
contributors
to
training-induced
ECM
remodeling,
show
PRDM16
transcriptional
complex
necessary
beiging,
discover
neuronal
growth
regulator
1
(NEGR1)
link
between
neuritogenesis.
Moreover,
shift
from
hypertrophic
insulin-sensitive
adipocyte
subpopulations.
Exercise
leads
remarkable
adaptations
structure
cell-type
composition
can
confer
changes
metabolism.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 15, 2024
In
obesity,
sustained
adipose
tissue
(AT)
inflammation
constitutes
a
cellular
memory
that
limits
the
effectiveness
of
weight
loss
interventions.
Yet,
impact
fasting
regimens
on
regulation
AT
immune
infiltration
is
still
elusive.
Here
we
show
intermittent
(IF)
exacerbates
lipid-associated
macrophage
(LAM)
inflammatory
phenotype
visceral
in
obese
mice.
Importantly,
this
increase
LAM
abundance
strongly
p53
dependent
and
partly
mediated
by
p53-driven
adipocyte
apoptosis.
Adipocyte-specific
deletion
prevents
accumulation
during
IF,
increases
catabolic
state
adipocytes,
enhances
systemic
metabolic
flexibility
insulin
sensitivity.
Finally,
cohorts
obese/diabetic
patients,
describe
polymorphism
links
to
efficacy
fasting-mimicking
diet
expression
TREM2
negatively
correlates
with
maintaining
after
bariatric
surgery.
Overall,
our
results
demonstrate
signalling
adipocytes
dictates
under
IF
modulates
mice
humans.
Molecular Aspects of Medicine,
Год журнала:
2024,
Номер
97, С. 101277 - 101277
Опубликована: Май 24, 2024
Excessive
accumulation
of
intermuscular
adipose
tissue
(IMAT)
is
a
common
pathological
feature
in
various
metabolic
and
health
conditions
can
cause
muscle
atrophy,
reduced
function,
inflammation,
insulin
resistance,
cardiovascular
issues,
unhealthy
aging.
Although
IMAT
results
from
fat
muscle,
the
mechanisms
underlying
its
onset,
development,
cellular
components,
functions
remain
unclear.
levels
are
influenced
by
several
factors,
such
as
changes
environment,
type
origin,
extent
duration
trauma,
persistent
activation
fibro-adipogenic
progenitors
(FAPs).
FAPs
diverse
transcriptionally
heterogeneous
population
stromal
cells
essential
for
maintenance,
neuromuscular
stability,
regeneration.
However,
cases
chronic
inflammation
conditions,
expand
differentiate
into
adipocytes,
resulting
development
abnormal
ectopic
IMAT.
This
review
discusses
role
adipogenesis
how
they
remodel
It
highlights
evidence
supporting
FAP-derived
adipocytes
constituents
IMAT,
emphasizing
their
significance
maintenance
well
involvement
disorders,
pathologies
diseases.
We
also
investigated
intricate
molecular
pathways
cell
interactions
governing
FAP
behavior,
adipogenesis,
diseases
deconditioning.
Finally,
we
hypothesize
that
impaired
flexibility
dysfunctional
muscles
impacts
FAPs,
leading
to
A
deeper
understanding
biology
regulating
behavior
fate
new
therapeutic
strategies
debilitating
conditions.
