Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease

Neurotherapeutics, Год журнала: 2025, Номер unknown, С. e00586 - e00586

Опубликована: Апрель 1, 2025

Язык: Английский

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Reductive stress in cancer: coming out of the shadows

Trends in cancer, Год журнала: 2023, Номер 10(2), С. 103 - 112

Опубликована: Ноя. 2, 2023

Язык: Английский

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Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

Cancer Research, Год журнала: 2023, Номер 83(12), С. 1953 - 1967

Опубликована: Апрель 16, 2023

Mutations in the KEAP1-NRF2 (Kelch-like ECH-associated protein 1-nuclear factor-erythroid 2 p45-related factor 2) pathway occur up to a third of non-small cell lung cancer (NSCLC) cases and often confer resistance therapy poor outcomes. Here, we developed murine alleles KEAP1 NRF2 mutations found human NSCLC comprehensively interrogated their impact on tumor initiation progression. Chronic stabilization by Keap1 or Nrf2 mutation was not sufficient induce tumorigenesis, even absence suppressors, p53 LKB1. When combined with KrasG12D/+, constitutive activation promoted early progression hyperplasia low-grade tumors but impaired advanced-grade tumors, which reversed deletion. Finally, overexpression mutant lines detrimental proliferation, viability, anchorage-independent colony formation. Collectively, these results establish context-dependence activity threshold for during tumorigenic process.

Язык: Английский

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Hypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming

Cell Death and Disease, Год журнала: 2023, Номер 14(9)

Опубликована: Сен. 20, 2023

Abstract Aldehyde dehydrogenase 3A1 (ALDH3A1) is an NAD + -dependent enzyme that closely related to tumor development. However, its role in non-small-cell lung cancer (NSCLC) has not been elucidated. This study aimed clarify the mechanism of ALDH3A1 and identify potential therapeutic targets for NSCLC. Here, first time, we found expression could be induced by a hypoxic environment was highly expressed NSCLC tissue, especially some late-stage patients, associated with poor prognosis. In mechanistic terms, enhances glycolysis suppresses oxidative phosphorylation (OXPHOS) promote cell proliferation activating HIF-1α/LDHA pathway addition, results showed target β-elemene. can downregulated β-elemene inhibit enhance OXPHOS, thus suppressing vitro vivo. conclusion, hypoxia-induced energy metabolic status tumors efficacy β-elemene, providing new theoretical basis better clinical applications

Язык: Английский

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Peiminine triggers ferroptosis to inhibit breast cancer growth through triggering Nrf2 signaling

Tissue and Cell, Год журнала: 2024, Номер 87, С. 102323 - 102323

Опубликована: Фев. 4, 2024

Язык: Английский

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