Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches? DOI Creative Commons
Alfredo Franco‐Obregón, Yee Kit Tai

Cells, Год журнала: 2024, Номер 13(15), С. 1273 - 1273

Опубликована: Июль 29, 2024

Transient receptor potential (TRP) channels are broadly implicated in the developmental programs of most tissues. Amongst these tissues, skeletal muscle and adipose noteworthy for being essential establishing systemic metabolic balance. TRP respond to environmental stimuli by supplying intracellular calcium that instigates enzymatic cascades consequence often impinge on mitochondrial function biogenesis. Critically, aminoglycoside antibiotics (AGAs) have been shown block capacity conduct entry into cell response a wide range biophysical nature, including mechanical, electromagnetic, thermal, chemical. Paradoxically, vitro paradigms commonly used understand organismal development may led astray conventional use streptomycin, an AGA, help prevent bacterial contamination. Accordingly, streptomycin has disrupt both vivo myogenesis, as well phenotypic switch white beige thermogenic status. In vivo, TRP-mediated calcium-dependent exercise adaptations importance metabolism. Alternatively, also curb detrimental levels leakage dystrophic through aberrantly gated TRPC1 be involved etiology X-linked muscular dystrophies. susceptible AGA antagonism critically modulating tissues that, if administered behaving animals, translate systemwide disruption. Regenerative medicine clinical communities need made aware this caveat usage seek viable alternatives, contamination or infection paradigms, respectively.

Язык: Английский

Photodegradation Controls of Potential Toxicity of Secondary Sunscreen-Derived Microplastics and Associated Leachates DOI Creative Commons

Aries Wei Sun,

Wen‐Xiong Wang

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

The escalating environmental concern over secondary microplastics (SMPs) stems from their physicochemical evolution primary (PMPs), yet the contribution of varying transformations to ultimate risks remains unknown. In this study, a photomechanical degradation process was employed convert sunscreen-derived (SDMPs) into SDMPs. While mechanical caused physical fragmentation, photodegradation induced both and chemical alterations, introducing surface oxidation, bond scission, cross-linking Employing combination alkaline digestion pyrolysis GC-MS techniques, it observed that fragmentation photooxidation led heightened intracellular sequestration MPs. Although bioaccumulated SDMPs could be indicated by enlarged lysosomes fragmented mitochondria, toxicity at cellular level primarily driven post-photodegradation. A nontargeted analysis employing high-resolution mass spectrometry identified 46 plastic-associated compounds in leachate, with photodegradation-induced playing crucial role dissociation hydrophobic additives oxidative conversion leached compounds. leachate exacerbated photodegradation, mitochondrial serving as subcellular biomarker, indicative toxicity. This study elucidates pivotal augmenting cytotoxicity SDMPs, shedding light on intricate interplay between risks.

Язык: Английский

Процитировано

0
Mitochondrial genetics, signalling and stress responses DOI
Yasmine J. Liu, Jonathan Sulc, Johan Auwerx

и другие.

Nature Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
Transgenerational Inheritance of Mitochondrial Hormetic Oxidative Stress Mediated by Histone H3K4me3 and H3K27me3 Modifications DOI Creative Commons

Yimin Li,

Chongyang Wang,

Xiaoxia Fu

и другие.

Redox Biology, Год журнала: 2025, Номер 82, С. 103598 - 103598

Опубликована: Март 15, 2025

Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease; however, its effects on epigenetic inheritance organism fitness across generations remains elusive. Utilizing the C. elegans as a model, we elucidate that parental exposure to mtHOS not only elicits lifespan extension exposed individuals but also confers this longevity advantage progeny through transgenerational (TEI) mechanism. This transmission of prolongation depends activation UPRmt synergistic action transcription factors DAF-16/FOXO SKN-1/Nrf2. Additionally, H3K4me3 H3K27me3 serve mediators, selectively marking regulating expression genes associated with response determination. Our findings illuminate mechanisms underlying implementation mtHOS, revealing sophisticated interplay among chromatin remodeling collectively enhances progeny's adaptive resilience future challenges.

Язык: Английский

Процитировано

0
Thermogenesis and Energy Metabolism in Brown Adipose Tissue in Animals Experiencing Cold Stress DOI Open Access
Xiang Zhang, Xiao Jin, Min Jiang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3233 - 3233

Опубликована: Март 31, 2025

Cold exposure is a regulatory biological functions in animals. The interaction of thermogenesis and energy metabolism brown adipose tissue (BAT) important for metabolic regulation cold stress. Brown adipocytes (BAs) produce uncoupling protein 1 (UCP1) mitochondria, activating non-shivering (NST) by fuel combustion from ATP production response to stimuli. To elucidate the mechanisms underlying BAT under stress, we explored how triggers activation regulates overall metabolism. First, briefly outline precursor composition function BA. Second, explore roles cAMP- kinase A (PKA) adenosine monophosphate-activated (AMPK) signaling pathways BA during Then, analyze mechanism which mitochondria homeostasis balance This research reveals potential therapeutic targets, such as PKA, AMPK, UCP1 PGC-1α, can be used develop innovative strategies treating diseases. Furthermore, it provides theoretical support optimizing stress strategies, including pharmacological genetic modulation thermogenic pathways, improve livestock.

Язык: Английский

Процитировано

0
Cellular stress and macrophage activation DOI
Jing Yu, Bin‐Zhi Qian

Seminars in Immunology, Год журнала: 2025, Номер 78, С. 101953 - 101953

Опубликована: Апрель 12, 2025

Язык: Английский

Процитировано

0
Mitochondrial quality control and stress signaling pathways in the pathophysiology of cardio-renal diseases DOI Creative Commons
Isabel Amador‐Martínez, Ana Karina Aranda‐Rivera,

Mauricio Raziel Martínez-Castañeda

и другие.

Mitochondrion, Год журнала: 2025, Номер unknown, С. 102040 - 102040

Опубликована: Апрель 1, 2025

Mitochondria are essential organelles for cellular function and have become a broad field of study. In cardio-renal diseases, it has been established that mitochondrial dysfunction is primary mechanism leading to these pathologies. Under stress, mitochondria can develop stress response mechanisms maintain quality control (MQC) functions. contrast, the perturbation associated with pathogenesis several diseases. Thus, targeting specific pathways within MQC could offer therapeutic avenue protecting integrity. However, related signaling in axis poorly explored. The limitations include lack reproducibility experimental models disease, incomplete knowledge molecules generate bidirectional damage, temporality study models. Therefore, we believe integration all those limitations, along recent advances (i.e., mitophagy), (e.g., integrated response, unfolded protein import), pharmacology, targeted approaches reveal what deregulation like provide ideas generating strategies seek avoid progression

Язык: Английский

Процитировано

0
Transcriptomic analysis of mitohormesis associated with lifespan extension inCaenorhabditis elegans DOI Creative Commons
J. Kim,

Naibedya Dutta,

Gilberto J. Garcia

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Abstract Non-lethal exposure to mitochondrial stress has been shown have beneficial effects due activation of signalling pathways, including the unfolded protein response (UPR mt ). Activation UPR restores function mitochondria and improves general health longevity in multiple model systems, termed mitohormesis. In C. elegans , mitohormesis can be accomplished by electron transport chain inhibition, decline translation, decreased import, numerous other methods that activate . However, not all promote longevity. These studies started question whether MT is directly correlated with Here, we attempt address this controversy unravelling complex molecular regulation nematode under different stressors induce performing RNA-sequencing profile transcriptome changes. Using comprehensive unbiased approach, aim determine specific transcriptomic changes reveal a correlation between Altogether study will provide mechanistic insights on how it correlates lifespan

Язык: Английский

Процитировано

0
Ernährung – Physiologie und Pathophysiologie DOI

Malte Herberhold,

Anneke Dubbeldam

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 85 - 177

Опубликована: Янв. 1, 2025

Процитировано

0
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice DOI Creative Commons

Pablo Morgado-Cáceres,

Hernán Huerta, Christiane Copie‐Bergman

и другие.

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging DOI Creative Commons
Carolin Thomas, Reto Erni, Jia Yee Wu

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Дек. 8, 2023

Abstract To ameliorate or even prevent signatures of aging in ultimately humans, we here report the identification a previously undescribed polyacetylene contained root carrots ( Daucus carota ), hereafter named isofalcarintriol, which reveal as potent promoter longevity nematode C. elegans . We assign absolute configuration compound (3 S ,8 R ,9 , E )-heptadeca-10-en-4,6-diyne-3,8,9-triol, and develop modular asymmetric synthesis route for all -isofalcarintriol stereoisomers. At molecular level, isofalcarintriol affects cellular respiration mammalian cells, mice, interacts with α-subunit mitochondrial ATP synthase to promote biogenesis. Phenotypically, this also results decreased cancer cell growth, well improved motility stress resistance paralleled by reduced protein accumulation nematodal models neurodegeneration. In addition, supplementation both wild-type C57BL/6NRj mice on high-fat diet, aged chow diet glucose metabolism, increased exercise endurance, attenuated parameters frailty at an advanced age. Given these diverse effects health nematodes might become promising mitohormesis-inducing delay, ameliorate, aging-associated diseases humans.

Язык: Английский

Процитировано

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