Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure
Cell Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 12, 2025
Abstract
Androgen
exposure
(AE)
poses
a
profound
health
threat
to
women,
yet
its
transgenerational
impacts
on
male
descendants
remain
unclear.
Here,
employing
large-scale
mother-child
cohort,
we
show
that
maternal
hyperandrogenism
predisposes
sons
β-cell
dysfunction.
Male
offspring
mice
with
prenatal
AE
exhibited
hyperglycemia
and
glucose
intolerance
across
three
generations,
which
were
further
exacerbated
by
aging
high-fat
diet.
Mechanistically,
compromised
insulin
secretion
underlies
this
susceptibility
diabetes.
Integrated
analyses
of
methylome
transcriptome
revealed
differential
DNA
methylation
functional
genes
in
AE-F1
sperm,
was
transmitted
AE-F2
islets
retained
leading
reduced
expression
related
secretion,
including
Pdx1
,
Irs1
Ptprn2
Cacna1c
.
The
signatures
sperm
corroborated
diabetic
humans
the
blood
hyperandrogenism.
Moreover,
caloric
restriction
metformin
treatments
normalized
males
blocked
their
inheritance
restoring
aberrant
methylations.
Our
findings
highlight
impaired
homeostasis
from
via
changes,
providing
biomarkers
therapeutic
strategies
safeguard
future
generations’
metabolic
health.
Язык: Английский
The Role of Epigenetics in Long Term Impacts of Biological Communication Disruption
Опубликована: Янв. 1, 2025
Язык: Английский
Genetic signatures of suicide attempt behavior: insights and applications
Expert Review of Proteomics,
Год журнала:
2024,
Номер
21(1-3), С. 41 - 53
Опубликована: Фев. 5, 2024
Introduction
Every
year
about
800,000
complete
suicide
events
occur.
The
identification
of
biologic
markers
to
identify
subjects
at
risk
would
be
helpful
in
targeting
specific
support
treatments.
Язык: Английский
Epigenetic Biomarker for Preeclampsia Associated Preterm Birth and Potential Preventative Medicine
Current Zoology,
Год журнала:
2024,
Номер
10(1)
Опубликована: Янв. 1, 2024
Abstract
Preterm
birth
(PTB)
has
dramatically
increased
within
the
population
(i.e.
>10%)
and
preeclampsia
is
a
significant
sub-category
of
PTB.
Currently,
there
are
no
practical
clinical
parameters
or
biomarkers
which
predict
induced
The
current
study
investigates
potential
use
epigenetic
(DNA
methylation)
alterations
as
maternal
biomarker.
Non-preeclampsia
term
births
were
compared
to
PTBs
identify
DNA
methylation
differences
biomarker).
Maternal
buccal
cell
cheek
swabs
used
marker
for
systemic
in
individuals,
primarily
due
environmentally
early
life
previous
generations
impacts,
minimally
impacted
associated
with
disease
etiology
gestation
variables.
A
total
389
differential
regions
(DMRs)
identified
presence
preeclampsia.
DMRs
genome-wide
predominantly
low
CpG
density
(<2
CpG/100
bp).
In
comparison
PTB
biomarker
was
15%
(60
DMR)
overlap,
indicating
that
majority
unique
Few
previously
genes
have
been
identified,
however,
had
gene
associations
P13
K-Akt
signaling
pathway
metabolic
family,
such
phospholipid
pathway.
Preliminary
validation
DMR
cross-validation
analysis
on
samples
provided
78%
accuracy.
Although
prospective
expanded
trials
first
trimester
pregnancies
comparisons
required,
provides
proof
concept
may
exist.
availability
susceptibility
facilitate
management
allow
preventative
medicine
approaches
treat
condition
prior
its
occurrence.
Язык: Английский
Semen Analysis: Assaying Sperm Epigenetics
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
The influence of epigenetic regulation on development of multifactorial diseases
Russian Family Doctor,
Год журнала:
2024,
Номер
28(4), С. 39 - 49
Опубликована: Дек. 15, 2024
Multifactorial
diseases
pose
a
growing
challenge
to
global
healthcare
due
their
rapidly
increasing
prevalence,
high
mortality
rates,
and
significant
contribution
disability
among
the
working-age
population.
Intensive
research
aimed
at
improving
early
diagnosis,
prevention,
treatment
has
underscored
critical
role
of
epigenetic
changes,
which
influence
gene
expression
without
altering
primary
DNA
sequence.
This
article
provides
an
overview
mechanisms
involved
in
regulation,
including
methylation,
post-translational
histone
modifications,
non-coding
microRNAs
silencing.
Epigenetic
factors
serve
as
bridge
between
genome
environmental
influences.
Environmental
risk
factors—shaped
by
lifestyle,
behavior,
ecological
exposures,
psycho-emotional
stress—play
phenotypic
manifestations
overall
human
health.
The
reversibility
regulating
can
lead
both
beneficial
adverse
health
outcomes.
continuous
development
new
technologies
positions
epigenetics
promising
field
for
functional
research,
with
potential
fundamentally
transform
therapeutic
approaches
multifactorial
diseases.
Язык: Английский