Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4300 - 4300
Опубликована: Дек. 12, 2024
Objectives:
To
explore
whether
the
triglyceride–glucose
(TyG)
index
and
triglyceride
to
high-density
lipoprotein
cholesterol
(TG/HDL-C)
ratio
are
associated
with
trajectories
of
depressive
symptoms.
Methods:
In
this
longitudinal
study,
4215
participants
aged
45
years
older
were
recruited
from
China
Health
Retirement
Longitudinal
Study
2011
2018.
The
symptoms,
measured
by
10-item
Center
for
Epidemiologic
Studies
Depression
Scale
(CESD-10),
identified
using
group-based
trajectory
modeling.
Multinomial
logistic
models
restricted
cubic
spline
analysis
used
investigate
relationships
between
TyG
TG/HDL-C
Stratified
analyses
conducted
based
on
sex,
age,
place
residence,
body
mass
(BMI).
Results:
Five
distinct
symptoms
characterized
stable
low,
moderate,
decreasing,
increasing,
high
during
a
follow-up
7
years.
associations
not
entirely
consistent.
After
adjusting
covariates,
higher
at
baseline
was
lower
odds
being
decreasing
(ORad
=
0.61,
95%
CI:
0.40–0.92)
compared
low
trajectory,
revealed
negative
linear
relationship
likelihood
However,
no
longer
statistically
significant
when
all
confounders
controlled
0.72,
0.50−1.04).
Additionally,
association
observed
among
45–64-year-old
individuals,
female
participants,
those
living
in
rural
areas,
normal
BMI.
Limitations:
This
study
middle-aged
elderly
population
China,
extrapolation
other
regions
populations
requires
further
confirmation.
Conclusions:
Compared
ratio,
may
be
better
predictor
adults.
Considering
that
pathology
depression
progresses
long
term,
our
findings
have
utility
identifying
available
reliable
markers
development
depression.
ABSTRACT
Integrating
dietary
interventions
have
been
extensively
studied
for
their
health
benefits,
such
as
Alzheimer's
disease,
Huntington's
and
aging.
However,
it
is
necessary
to
fully
understand
the
mechanisms
of
long‐term
effects
practical
applications
these
health.
A
10‐week
intermittent
fasting
(IMF)
regimen
was
implemented
on
aging
animals
in
current
study.
The
variations
cerebral
functions
were
analyzed
employing
a
comprehensive
experimental
design
that
includes
behavioral
tests,
neuroimaging,
ultrastructural
analysis,
resting‐state
functional
MRI
(rsfMRI),
EEG/EMG
recordings,
transmission
electron
microscopy,
immunohistochemistry.
Over
regimen,
IMF
significantly
improved
locomotor
activity,
motor
coordination,
muscle
strength
compared
controls
(
p
<
0.01).
Resting‐state
fMRI
(rsfMRI)
demonstrated
modulates
brain‐wide
connectivity,
enhancing
communication
between
key
brain
regions.
Advanced
imaging
techniques
revealed
increased
expression
myelin‐related
proteins,
including
myelin
basic
protein
(MBP),
myelin‐associated
glycoprotein
(MAG),
indicating
enhanced
integrity
repair,
particularly
axons
with
diameters
400
nm
These
findings
suggest
may
mitigate
age‐related
declines
by
promoting
better
neuronal
signaling.
This
study
highlights
potential
function
non‐pharmacological
intervention
promote
cognitive
decline
populations.
Abstract
Platelet
hyperreactivity
contributes
significantly
to
thrombosis
in
acute
myocardial
infarction
and
stroke.
While
antiplatelet
drugs
are
used,
residual
ischemic
risk
remains.
Intermittent
fasting
(IF),
a
dietary
pattern
characterized
by
alternating
periods
of
eating
fasting,
has
shown
cardiovascular
benefits,
but
its
effect
on
platelet
activation
is
unclear.
This
study
demonstrates
that
IF
inhibits
both
patients
with
coronary
artery
disease
apolipoprotein
E
(ApoE)
knockout
(ApoE−/−)
mice,
enhancing
intestinal
flora
production
indole-3-propionic
acid
(IPA).
Mechanistically,
elevated
IPA
plasma
directly
attenuates
binding
the
pregnane
X
receptor
(PXR)
suppressing
downstream
signaling
pathways,
including
Src/Lyn/Syk
LAT/PLCγ/PKC/Ca2+.
Importantly,
alleviates
cerebral
ischemia/reperfusion
injury
ApoE−/−
mice.
These
findings
suggest
mitigates
atherosclerosis
IPA,
which
subsequently
activates
PXR-related
pathways.
American Journal of Lifestyle Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Aging
increases
the
risk
of
neurodegenerative
diseases
(NDs)
like
Alzheimer's
(AD)
and
Parkinson's
(PD),
characterized
by
neuronal
loss
cognitive
decline.
Potential
preventive/therapeutic
interventions
also
include
lifestyle
changes
nutrition
&
diet,
exercise,
leisure
social
engagement.
Here,
we
discuss
several
for
healthy
brain
aging,
in
older
adults
with
NDs.
Balanced
diets
Mediterranean
MIND
can
reduce
decline
during
aging.
Long-term
use
specific
nutrient
combinations
medical
food
may
exert
benefits
on
memory.
Metabolic
calorie
restriction
(CR)
intermittent
fasting
(IF)
have
shown
potential
However,
their
effects
function
were
modestly
explored
remain
unclear.
Clinical
trials
are
ongoing
to
test
health
outcomes
CR/IF
variants
AD
or
PD
(associated
not
metabolic
disorders).
We
highlight
role
reserve
(CoR)
delaying
dementia
symptoms.
Engaging
diverse
activities
music
bilingualism
enhance
CoR
risk.
Finally,
outline
future
directions
promoting
aging
through
(e.g.,
personalized
diets,
precision
nutrition,
synergistic
approaches,
AI-based
technologies
monitor
effectiveness
practices).
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(21), С. 6607 - 6607
Опубликована: Ноя. 3, 2024
Insulin
acts
on
different
organs,
including
the
brain,
which
helps
it
regulate
energy
metabolism.
signaling
plays
an
important
role
in
function
of
cell
types.
In
this
review,
we
have
summarized
key
roles
insulin
and
receptors
healthy
brains
brain
disorders.
signaling,
as
well
resistance
(IR),
is
a
major
contributor
regulation
mood,
behavior,
cognition.
Recent
evidence
showed
that
both
peripheral
central
play
pathophysiology,
clinical
presentation,
management
neuropsychiatric
disorders
like
Cognitive
Impairment/Dementia,
Depression,
Schizophrenia.
Many
human
studies
point
out
Resistance/Metabolic
Syndrome
can
increase
risk
dementia
especially
Alzheimer’s
(AD).
IR
has
been
shown
to
AD
development
but
also
its
progression.
This
review
article
discusses
pathophysiological
pathways
mechanisms
The
extent
be
quantified
using
biomarkers
levels,
HOMA-IR
index,
Triglyceride
glucose–body
mass
index
(TyG–BMI)
levels.
precede
neurodegeneration.
Human
trials
current
treatment
with
certain
antidiabetic
drugs,
life
style
management,
weight
loss
exercise
for
IR,
promise
cognitive/neuropsychiatric
may
pave
pathway
new
therapeutic
approaches
these
challenging
psychiatric
diseases.
are
showing
some
encouraging
pharmacological
nonpharmacological
cognitive
disorders,
even
though
more
research
needed
apply
into
practice.
Early
identification
help
strategy
potentially
alter
onset
progression
