Dietary Beliefs and Their Association with Overweight and Obesity in the Spanish Child Population

Children, Год журнала: 2025, Номер 12(1), С. 76 - 76

Опубликована: Янв. 9, 2025

Background/Objectives: Childhood obesity is a multifactorial chronic disease that represents one of the main preventable causes morbidity and mortality. This study analyzes how nutritional beliefs influence eating habits prevalence overweight in Spanish children adolescents. Methods: A cross-sectional was conducted 35 educational centers 12 provinces, with sample 1131 adolescents aged 6 to 14 years. Anthropometric sociodemographic data were collected, dietary assessed by means questionnaires. Statistical analyses used identify associations between body mass index. Results: In total, 29.5% participants or obese. Two groups identified: healthier less healthy beliefs. Children had significantly higher BMI (22.16 kg/m2) compared those (17.2 kg/m2). False beliefs, influenced advertising family environment, contribute obesity. Discussion: Dietary play crucial role determining and, therefore, health children. Nutrition education public policies promote are essential prevent childhood It important involve family, school, media these efforts. Conclusions: Despite efforts, many continue hold erroneous rise highlights importance addressing promoting appropriate nutrition recommended implement strategies regulate unhealthy foods habits.

Язык: Английский

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Obesity and cardiometabolic disease: Insights from genetic studies

Canadian Journal of Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 10, 2025

Insulin resistance(IR) is associated with an increased risk of all-cause and cardiovascular death, modifiable healthy lifestyles play active role in the improvement IR reduction death. Whether health (CVH) within it can attenuate or even offset heightened perils both deaths insulin resistance remains unclear. The study encompassed 14,172 participants from 2005–2018 NHANES programme. was evaluated using TyG index, TyG-WC, TyG-WHtR, while CVH assessed employing LE8 score, addition to LE4 index redefined according four behaviours. Weighted multifactor Cox regression models were used assess association mortality, dose-response relationships restricted cubic spline. Furthermore, subjects grouped scores, generalised linear estimate weighted mortality death for each group calculate absolute difference. Finally, predicted probability as a function computed, complex relationship between three visualised two-dimensional scatter plots three-dimensional surface plots. Among included study, 1534 occurred over mean follow-up period 7.6 years (382 these due causes). analysis indicated that elevated TyG-WC TyG-WHtR correlated greater likelihood all causes events, whereas inversely risks. Additional stratification revealed notable events improved, irrespective presence resistance. Additionally, high but moderate did not have significantly risks compared those low Stratified 3D reduced resistance-related reductions observed at higher levels. In this cohort improving behaviors deaths. Maintaining levels (LE8 ≥ 50) could caused by

Язык: Английский

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The Effect of Hypertension, Obesity, and Type 2 Diabetes on Lacunar Stroke: A Network Mendelian Randomization Study

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 103974 - 103974

Опубликована: Март 1, 2025

Язык: Английский

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Impact of age on cardiometabolic health in children at adiposity rebound: the role of genetic mechanisms

World Journal of Pediatrics, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism

Biology Direct, Год журнала: 2025, Номер 20(1)

Опубликована: Март 19, 2025

Abstract Background N-glycosylation is a complex, post-translational modification which influences protein function and sensitive to physiological changes. Obesity associated with alterations in function; however, little known about the glycoproteome obesity beyond observations of association types structures selected glycopeptides. Most often, due technical challenges, glycan composition structure information are missing. Here, we combined label-free data-independent proteomics targeted quantitative glycoproteomics study plasma proteins obesity. Using monozygotic twin design, controlled for genetic variation focused only on acquired effects Methods samples 48 pairs discordant BMI (intrapair difference > 2.5 kg/m 2 ), identified using mass spectrometry, differential glycopeptide levels between heavier leaner co-twins. We used within-twin paired analysis model considered p < 0.05 as significant. Results 33 expression differences ( 0.05) These occurred either both glycoprotein (sometimes opposing directions) or independently from each other. Haptoglobin was upregulated (Fold Change = 1.10, 0.001) co-twins along seven compositions at site Asn241. The complement C3 1.08, 0.014) one Asn85. Additionally, many glycopeptides were despite non-significant protein-backbone levels. Conclusion Differential related cholesterol biosynthesis acute phase signalling well iron metabolism inflammation can be linked

Язык: Английский

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Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 20, 2025

Among different age groups, middle-aged individuals are particularly susceptible to obesity, with a 22% higher risk of all-cause mortality. However, the underlying mechanisms remain unclear. In this study, we identify adipose progenitor cells (APCs) in white tissue (WAT) subjects as potential causes midlife obesity. Specifically, extracellular vesicles (EVs) derived from APCs display an impaired ability mitigate inflammaging macrophages (ATMs) individuals. Mechanistically, these EVs, lacking miR-145-5p, fail suppress expression L-selectin ATMs, thereby facilitating their M1 program via NF-κB signaling pathway. contrast, EVs young effectively inhibit macrophage polarization. Accordingly, targeted liposomes designed deliver miR-145-5p mimics which prevent obesity mice. Collectively, our findings highlight role APC-derived and propose miR-145-5pas promising therapeutic target for clinical applications. Middle-aged more but Here, authors show that lack driving inflammation, restoring could

Язык: Английский

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Association between triglyceride glucose-body mass index and the trajectory of cardio-renal-metabolic multimorbidity: insights from multi-state modelling

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 21, 2025

Although some studies have examined the association between triglyceride glucose-body mass index (TyG-BMI) and cardiovascular outcomes in cardio-renal-metabolic (CRM) background, none explored its role progression of CRM multimorbidity. In addition, prior research is limited by small sample sizes a failure to account for competitive effects other diseases. this study, data obtained from large-scale, prospective UK Biobank cohort were used. multimorbidity was defined as new-onset ischemic heart disease, type 2 diabetes mellitus, or chronic kidney disease during follow-up. Multivariable Cox regression used analyse independent TyG-BMI each (first, double, triple diseases). The C-statistic calculated model, restricted cubic spline applied assess dose–response relationship. A multi-state model investigate trajectory (from baseline [without disease] first double disease), with disease-specific analyses. This study included 349,974 participants, mean age 56.05 (standard deviation [SD], 8.08), 55.93% whom female. Over median follow-up approximately 14 years, 56,659 (16.19%) participants without developed at least one including 8451 (14.92%) who progressed 789 (9.34%) further disease. crude SD increase associated 47% higher risk 72% 95% C-statistics 0.625, 0.694, 0.764, respectively. Multi-state analysis showed 32% increased new 24% 23% those significantly onset all individual diseases (except stroke) transition Significant interactions also observed, but remained across subgroups. Sensitivity analyses, varying time intervals entering states an expanded definition (including atrial fibrillation, failure, peripheral vascular obesity, dyslipidaemia), confirmed these findings. remarkably influences Incorporating it into prevention management could important public health implications.

Язык: Английский

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The global burden and biomarkers of cardiovascular disease attributable to ambient particulate matter pollution

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 22, 2025

Understanding the evolving patterns of cardiovascular disease (CVD) burden attributable to ambient particulate matter pollution (APMP) is essential. Furthermore, research on underlying mechanisms has mostly been limited laboratory and animal models, with few large-scale population-based studies. Using data from Global Burden Disease Study (GBD) 2021, we analyzed disability-adjusted life years mortality for CVD APMP (measured as [PM]2.5) 1990 2021. We examined shifts in between household air (HAP), regional disparities by socio-demographic index (SDI), predicted trends using a Bayesian age-period-cohort model. Additionally, used UK Biobank (UKB) (metabolomics: 230,000 + participants; proteomics: 50,000 +) identify biomarkers mediating association PM2.5 exposure outcomes, further their biological roles. Metabolic proteomic signatures were constructed regression elastic net predictive performance assessed via time-dependent receiver operating characteristic analysis. Life expectancy was evaluated flexible parametric survival models. Subgroup analysis conducted age, sex, lifestyle, socioeconomic status, genetic susceptibility. In global absolute more than double that 1990, significant disparities. The shifted HAP APMP, 15% cases globally attributed APMP. increased age projected rise through 2030. UKB, approximately 30 metabolites, including albumin, mediated primarily involving lipid fatty acids metabolism. Over 60 proteins, growth differentiation factor-15 trefoil factor 2, enriched cytokine-receptor interaction leukocyte migration pathways. outperformed alone predicting 1-, 5-, 10-year outcomes. Participants lowest decile exposure, metabolic, had longer those highest decile. remains critical public health concern. This study presents novel approach identifying managing susceptible populations metabolomic perspectives.

Язык: Английский

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Trends in Obesity Among Adults in Mississippi, 2017–2023

Obesities, Год журнала: 2025, Номер 5(2), С. 21 - 21

Опубликована: Апрель 1, 2025

The aim of this study was to analyze trends in rates obesity amongst Mississippi adults between 2017 and 2023 based on five health determinants: gender, education, age, race, socioeconomic status. We calculated standard errors using Microsoft Excel performed trend analysis Joinpoint Regression. Obesity prevalence among men showed a statistically significant increasing from 2023, with an Annual Percent Change 0.86%. Among college-level significantly increased by 2.33% per year. For most age groups, did not show indicating relatively stable over time. There annual increase 0.65% for African Americans. From 2022 there decrease Hispanics. 0.70%, which significant, Whites. the combined ≥USD 50,000 income group, 2019. remains critical public issue widespread consequences. Future research should explore long-term impact these assess effectiveness ongoing interventions guide more precise strategies prevention management.

Язык: Английский

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