Liver Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Abstract Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels the branched-chain amino acids (BCAAs) recapitulates many benefits low diet; BCAA-restricted diets extend lifespan, reduce frailty, improve metabolic health, while BCAA supplementation shortens promotes obesity, impairs glycemic control. Recently, high have been shown to promote cellular senescence, hallmark implicated age-related diseases, liver mice. Here, we test hypothesis that effects on health cell senescence are mediated by BCAAs. We find BCAAs protects male female from negative consequences normal diets. Further, identify tissue-specific with restriction all three – but not individual protecting hepatic potentiating white adipose tissue. cell-autonomous, lower cultured cells antimycin-A induced senescence. Our results demonstrate direct effect specific component suggest may be highly susceptible interventions.
Язык: Английский
Процитировано
0
Food Research International, Год журнала: 2025, Номер unknown, С. 116165 - 116165
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 499 - 499
Опубликована: Март 27, 2025
Cellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as senescence-associated secretory phenotype (SASP), causing chronic inflammation; at same time, inflammation leads to a decrease immune system function, immunosenescence, which further accelerates aging process. immunosenescence are closely related variety diseases, including cardiovascular metabolic disorders, autoimmune neurodegenerative diseases. Studying mechanisms cellular developing targeted interventions crucial for improving function quality life elderly people. Here, we review series recent studies focusing on molecular regulation by system, latest advances basic clinical research senolytics. We summarize animal models research, well mechanisms, strategies, future directions from immunological perspective, hope laying foundation novel practical anti-aging therapies.
Язык: Английский
Процитировано
0
Liver Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0