Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation DOI Creative Commons
Young‐Yon Kwon, Yanshan Liang, Maria Laura Gomez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Cancer cachexia is an involuntary weight loss condition characterized by systemic metabolic disorder. A comprehensive flux characterization of this however lacking. Here, we systematically isotope traced eight major circulating nutrients in mice bearing cachectic C26 tumors (cxC26) and food intake-matched non-cachectic (ncxC26). We found no difference whole-body lipolysis proteolysis, ketogenesis, or fatty acid ketone oxidation tissues between the two groups. In contrast, compared to ncxC26 ad libitum, glucose turnover decreased intake-controlled but not cxC26 mice. Similarly, sustained was observed autochthonous cancer models despite reduced intake. identified glutamine alanine as responsible for production with altered use lactate provide a view alterations revealing those distinct from nutrient Quantitative fluxomics under matched intake body weightIntact lipolysis, lipid miceSustained consumption intakeIncreased

Язык: Английский

Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation DOI Creative Commons
Young‐Yon Kwon, Yanshan Liang, Maria Laura Gomez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Cancer cachexia is an involuntary weight loss condition characterized by systemic metabolic disorder. A comprehensive flux characterization of this however lacking. Here, we systematically isotope traced eight major circulating nutrients in mice bearing cachectic C26 tumors (cxC26) and food intake-matched non-cachectic (ncxC26). We found no difference whole-body lipolysis proteolysis, ketogenesis, or fatty acid ketone oxidation tissues between the two groups. In contrast, compared to ncxC26 ad libitum, glucose turnover decreased intake-controlled but not cxC26 mice. Similarly, sustained was observed autochthonous cancer models despite reduced intake. identified glutamine alanine as responsible for production with altered use lactate provide a view alterations revealing those distinct from nutrient Quantitative fluxomics under matched intake body weightIntact lipolysis, lipid miceSustained consumption intakeIncreased

Язык: Английский

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