The Role of Extracellular Vesicles in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Liver Diseases DOI Open Access
Elena Grossini, Mohammad Mostafa Ola Pour, Sakthipriyan Venkatesan

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5033 - 5033

Опубликована: Май 23, 2025

The increasing prevalence of liver diseases, such as metabolic dysfunction-associated steatotic disease (MASLD), presents considerable medical challenges, particularly given the absence approved pharmacological treatments, which underscores necessity to comprehend its underlying mechanisms. Extracellular vesicles (EVs), are tiny particles released by cells, play a crucial role in facilitating communication and can transport harmful molecules that promote inflammation tissue damage. These EVs involved progression various types disorders since they aggravate oxidative stress. Because their critical role, it is believed widely initiation MASLD, well viral hepatitis, alcoholic disease, drug-induced injury, hepatocellular carcinoma. This review emphasizes recent findings regarding functions above pathologies potential new therapeutic targets, paving way for innovative approaches address those detrimental conditions.

Язык: Английский

Exploring the Nutraceutical Potential of a Food–Medicine Compound for Metabolic-Associated Fatty Liver Disease via Lipidomics and Network Pharmacology DOI Creative Commons

Yuru Deng,

Jie Cui,

Yuxuan Jiang

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1257 - 1257

Опубликована: Апрель 3, 2025

Metabolic-associated fatty liver disease (MAFLD) is a prevalent global health issue closely tied to dietary habits, impacting significant portion of the adult population. MAFLD linked various metabolic disorders, elevating risks cirrhosis and hepatocellular carcinoma severely patients' quality life. While therapeutic research has progressed, effective food-based interventions remain scarce. Natural products, rich in bioactive compounds offering benefits, have gained attention for their potential managing MAFLD. This study employed network pharmacology lipidomics investigate effects Food Medicine Homology (FMH) on using high-fat-diet-induced HepG2 cell model. We identified 169 components from Radix Puerariae, Hericium erinaceus, Rhizoma Curcumae longae, Camellia oleifera, Hoveniae Dulcis Semen, constructing drug-component-target that highlighted 34 key targets. The characteristic this FMH compound solution (HSD) were UPLC-QTOF-MS/MS. In vitro, HSD significantly reduced intracellular lipid accumulation, decreased inflammatory markers, mitigated hepatocyte damage. Lipidomics analysis revealed alterations metabolites, suggesting HSD's modulate sphingolipid glycerophospholipid metabolism, thus improving outcomes. underscores critical role complex modulating metabolism pathways, valuable insights developing FMH-based supplements functional foods alleviate By leveraging synergistic natural compounds, our findings hold implications innovative nutritional strategies disorder.

Язык: Английский

Процитировано

0
Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons

Yueying Yang,

E Wang,

Bing Zhou

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(5), С. 305 - 305

Опубликована: Апрель 26, 2025

RNA methylation plays a critical role in regulating all aspects of function, which are implicated the pathogenesis various human diseases. Recent studies emphasize 5-methylcytosine (m5C), an modification, key biological functions. Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as leading chronic condition globally. However, relationship between m5C and MASLD remains unclear. This study aimed to investigate modification mouse model MASLD. In this research, using transcriptome sequencing (RNA-Seq) methylated bisulfite (RNA-BS-Seq) leptin receptor-deficient mice, we found that genes associated with hypermethylation were primarily linked lipid metabolism. We identified 156 overlapping differentially expressed (DEGs) changed at both mRNA expression level level. Among them, 72 showed elevated modification. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses indicated these significantly metabolism-related signaling pathways. Our results demonstrate modifications may play important development

Язык: Английский

Процитировано

0
Aged polystyrene microplastics exacerbate cadmium-induced hepatotoxicity in zebrafish through gut-liver axis metabolic dysregulation DOI Creative Commons
Xue Li, Kaipeng Jing, Ping Song

и другие.

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Strontium Regulating Lipid Metabolism of Bovine Hepatocytes via SIRT1/SREBPs Pathway DOI

Fangyuan Zeng,

Wenjuan Hu, H. Y. Xu

и другие.

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер 252, С. 106785 - 106785

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

0
The Role of Extracellular Vesicles in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Liver Diseases DOI Open Access
Elena Grossini, Mohammad Mostafa Ola Pour, Sakthipriyan Venkatesan

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5033 - 5033

Опубликована: Май 23, 2025

The increasing prevalence of liver diseases, such as metabolic dysfunction-associated steatotic disease (MASLD), presents considerable medical challenges, particularly given the absence approved pharmacological treatments, which underscores necessity to comprehend its underlying mechanisms. Extracellular vesicles (EVs), are tiny particles released by cells, play a crucial role in facilitating communication and can transport harmful molecules that promote inflammation tissue damage. These EVs involved progression various types disorders since they aggravate oxidative stress. Because their critical role, it is believed widely initiation MASLD, well viral hepatitis, alcoholic disease, drug-induced injury, hepatocellular carcinoma. This review emphasizes recent findings regarding functions above pathologies potential new therapeutic targets, paving way for innovative approaches address those detrimental conditions.

Язык: Английский

Процитировано

0