Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study

Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1107 - 1107

Опубликована: Авг. 4, 2023

Prior evidence indicates the potential central role of acid sphingomyelinase (ASM)/ceramide system in infection cells with SARS-CoV-2. We conducted a multicenter retrospective observational study including 72,105 adult patients laboratory-confirmed SARS-CoV-2 who were admitted to 36 AP-HP (Assistance Publique-Hôpitaux de Paris) hospitals from 2 May 2020 31 August 2022. examined association between ongoing use medications functionally inhibiting (FIASMA), which reduces vitro, upon hospital admission 28-day all-cause mortality 1:1 ratio matched analytic sample based on clinical characteristics, disease severity and other (N = 9714). The univariate Cox regression model showed that FIASMA medication at was associated significantly lower risks (HR 0.80; 95% CI 0.72-0.88; p < 0.001). In this study, substantially reduced among hospitalized COVID-19. These findings support continuation these during treatment infections. Randomized trials (RCTs) are needed confirm results, starting molecules greatest effect size e.g., fluoxetine, escitalopram, amlodipine.

Язык: Английский

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Specific adverse outcomes associated with selective serotonin reuptake inhibitors use in COVID-19 patients might be potentiated by remdesivir use

Journal of Psychopharmacology, Год журнала: 2024, Номер 38(4), С. 395 - 403

Опубликована: Март 13, 2024

Background: Due to non-consistent reports in the literature, there are uncertainties about potential benefits and harms of selective serotonin reuptake inhibitors (SSRIs) patients with Coronavirus disease 2019 (COVID-19). Aim: To investigate associations SSRIs clinical characteristics unwanted outcomes among real-life severe critical COVID-19 their relationship remdesivir (RDV) use. Methods: This retrospective cohort study evaluated a total 1558 white race treated tertiary center institution, them 779 RDV 1:1 case-matched patients. Results: A 78 (5%) were exposed during hospitalization, similarly distributed matched (5.1 4.9%). No significant SSRI use age, sex, comorbidity burden, severity present either two cohorts ( p > 0.05 for all analyses). In multivariate analyses adjusted clinically meaningful variables, was significantly associated higher mortality (adjusted odds ratio (aOR) 2.0, = 0.049) (aOR 2.22, 0.044) risk mechanical-ventilation 2.57, 0.006), venous-thromboembolism 3.69, 0.007), bacteremia Conclusions: Adverse might be potentiated by use, interactions between these drug classes exist. Although our findings raise important considerations practice, they limited nature study, lack ethnic diversity, unmeasured confounding factors. Future studies exploring underlying biological mechanisms needed.

Язык: Английский

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Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1278 - 1278

Опубликована: Сен. 26, 2024

As the most common psychiatric symptom, depression represents a subject of high interest for medical community.

Язык: Английский

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Early Fluvoxamine Reduces the Risk for Clinical Deterioration in Symptomatic Outpatients with COVID-19: A Real-World, Retrospective, before–after Analysis

Microorganisms, Год журнала: 2023, Номер 11(8), С. 2073 - 2073

Опубликована: Авг. 12, 2023

Fluvoxamine, a selective serotonin reuptake inhibitor with anti-inflammatory properties, has gained attention as repurposed drug to treat COVID-19. We aimed explore the potential benefit of fluvoxamine on outpatients early SARS-CoV-2 infection. performed retrospective study adult symptomatic COVID-19 disease onset (<5 days), in context an infectious diseases private practice, between September-December 2021, Greece. Patients duration ≥5 days, dyspnea and/or hypoxemia oxygen saturation <94% room air and pregnancy were excluded from analysis. In total, 103 patients, 54 males/49 females median age 47 years (39-56), included this study. Patient characteristics balanced before after introduction fluvoxamine. Two patients arm (3.8%; 95% CI 0.4-13) had clinical deterioration compared 8 standard care group (16%; 7.2-29.1, p < 0.04). After controlling for age, sex, body mass index > 30 vaccination status, was independently associated lower risk (adj. OR 0.12; 0.02-0.70, 0.02). Adding treatment may protect them hospitalization, it is appealing low-cost, low-toxicity option community setting warrants further investigation.

Язык: Английский

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Comorbidity Patterns and Mortality Among Hospitalized Patients with Psychiatric Disorders and COVID-19

Brazilian Journal of Psychiatry, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

To examine the association between psychiatric and non-psychiatric comorbidity 28-day mortality among patients with disorders COVID-19.We performed a multicenter observational retrospective cohort study of adult hospitalized laboratory-confirmed COVID-19 at 36 Greater Paris University hospitals (January 2020-May 2021) (N=3,768). First, we searched for different subgroups according to their comorbidities through cluster analysis. Next, compared all-cause rates across identified clusters, while taking into account sex, age, number medical conditions.We found 5 clusters distinct patterns. Twenty-eight-day in mood was significantly lower than other clusters. There were no significant differences clusters.All conditions may be associated increased COVID-19. The risk death might line potential beneficial effect certain antidepressants COVID-19, but requires further research. These findings help identify at-risk who should benefit from vaccine booster prioritization prevention measures.

Язык: Английский

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Efficacy of Fluvoxamine in Outpatients With COVID-19: Understanding Conflicting Conclusions From 2 Recent Meta-Analyses of the Same Clinical Trials

Annals of Pharmacotherapy, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 28, 2023

Язык: Английский

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Die Bedeutung von Antidepressiva bei COVID-19 und Long-COVID – Ein Scoping-Review Update

Fortschritte der Neurologie · Psychiatrie, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.

Язык: Английский

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Re: ‘efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis’ by Deng et al.

Clinical Microbiology and Infection, Год журнала: 2023, Номер 29(6), С. 814 - 814

Опубликована: Фев. 4, 2023

Язык: Английский

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Negative Prognostic Associations of Selective Serotonin Reuptake Inhibitors Use in Hospitalized COVID-19 Patients and Potential Contribution of Cardiovascular Comorbidities

Pharmacology, Год журнала: 2024, Номер unknown, С. 1 - 8

Опубликована: Июль 31, 2024

<b><i>Introduction:</i></b> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of disease 2019 (COVID-19), very contagious systemic dominantly affecting the tract. Recent findings oppose earlier suggestions that selective serotonin reuptake inhibitors (SSRIs) might be protective during SARS-CoV-2 infection, prompting current study. <b><i>Methods:</i></b> The institutional registry tertiary referral center was retrospectively evaluated for SSRI use and associated clinical outcomes among hospitalized COVID-19 patients with mostly severe critical disease. <b><i>Results:</i></b> Among 1,558 patients, there were 78 (5%) exposed to hospitalization. users in comparison non-users did not significantly differ their demographic characteristics, comorbidity profile or severity symptoms inflammatory response at admission. In multivariate analyses adjusted clinically meaningful variables, higher risks death, mechanical ventilation, intensive care unit treatment, bacteremia, whereas no significant relationship venous, arterial thrombosis, major bleeding present. Patients less initial presentation, lower burden, platelet count, cumulative presence hyperlipidemia, atrial fibrillation, chronic heart failure nonexposed acetylsalicylic-acid had mortality use. <b><i>Conclusions:</i></b> Findings study validate but also report tendency deterioration, bacteremia patients. These suggest potential contribution cardiovascular comorbidities detrimental course

Язык: Английский

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Enhanced Production of Therapeutic Metabolites in Cork-Oak Somatic Embryos under Abiotic Stress Conditions

Stresses, Год журнала: 2024, Номер 4(3), С. 546 - 557

Опубликована: Сен. 3, 2024

This study investigates the enhanced production of key therapeutic metabolites (ellagic acid, serotonin, and chlorogenic acid) in response to abiotic stress vitro cultures Quercus suber somatic embryos. Findings indicate significant increases metabolite levels under various conditions, highlighting potential for commercial-scale these compounds, known their antioxidant, anticancer, anti-COVID-19 properties. Under osmotic/saline stress, ellagic acid significantly increased, representing an 80% increase compared control conditions. In embryos exposed different stressors, serotonin accumulation showed a six-fold stress. Although elicitors used did not levels, exploring alternative types may enhance its production. research paves way sustainable, large-scale health-beneficial metabolites, addressing global health challenges promoting resource sustainability.

Язык: Английский

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