Intra-abdominal Mucormycosis in an Immunocompetent Host: A Rare Presentation and Literature Review DOI Open Access
Sevag Hamamah,

Nupur Savalia,

Faizi Hai

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Mucormycosis is a severe, opportunistic infection caused by Mucorales, taxonomical group of thermotolerant fungi primarily affecting the immunocompromised. Intra-abdominal involvement in mucormycosis rare entity, particularly immunocompetent individuals. We present fatal case gallbladder and renal an female, leading to septic shock death. The diagnosis was confirmed via histopathology following cholecystectomy for suspected gangrenous cholecystitis open right nephrectomy due kidney infarction. Quantitative polymerase chain reaction tissue identified presence Apophysomyces ossiformis. clinical picture confounded ongoing sepsis Klebsiella pneumoniae-infected retroperitoneal hematoma, non-specific imaging findings, absence traditional risk factors mucormycosis, delayed diagnosis. Despite surgical debridement, initiation liposomal amphotericin B with posaconazole, aggressive treatment intensive care unit, patient succumbed complications mucormycosis. adequate antibiotic coverage, this underscores importance considering Mucorales otherwise patients deteriorating condition. Early appropriate intervention are essential enhancing survivability, though mortality rates remain high severe cases.

Язык: Английский

Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management DOI
George R. Thompson, Jeffrey D. Jenks, John W. Baddley

и другие.

Clinical Microbiology Reviews, Год журнала: 2023, Номер 36(3)

Опубликована: Июль 13, 2023

Fungal endocarditis accounts for 1% to 3% of all infective cases, is associated with high morbidity and mortality (>70%), presents numerous challenges during clinical care. Candida spp. are the most common causes fungal endocarditis, implicated in over 50% followed by Aspergillus Histoplasma Important risk factors include prosthetic valves, prior heart surgery, injection drug use.

Язык: Английский

Процитировано

44
The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation DOI Creative Commons
Giacomo Casalini, Andrea Giacomelli, Spinello Antinori

и другие.

The Lancet Microbe, Год журнала: 2024, Номер 5(7), С. 717 - 724

Опубликована: Апрель 9, 2024

In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 entities into three groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both development needs perceived public health importance. this Personal View, we discuss positioning pathogens, namely, Mucorales, Candida spp, Histoplasma Coccidioides Paracoccidioides Fusarium eumycetoma causative agents, Talaromyces marneffei, Pneumocystis jirovecii, while expressing concerns about potential disparities between list actual disease burden associated with these pathogens. Finally, propose a revised that also considers regional in diseases.

Язык: Английский

Процитировано

43
Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections DOI
Romain Pirracchio,

Balasubramanian Venkatesh,

Matthieu Legrand

и другие.

JAMA, Год журнала: 2024, Номер 332(4), С. 318 - 318

Опубликована: Июнь 12, 2024

Importance Severe pulmonary infections, including COVID-19, community-acquired pneumonia, influenza, and Pneumocystis are a leading cause of death among adults worldwide. Pulmonary infections in critically ill patients may septic shock, acute respiratory distress syndrome, or both, which associated with mortality rates ranging between 30% 50%. Observations Corticosteroids mitigate the immune response to infection improve outcomes for several types severe infections. Low-dose corticosteroids, defined as less than equal 400 mg hydrocortisone equivalent daily, can reduce pneumonia. A randomized clinical trial 6425 hospitalized COVID-19 who required supplemental oxygen noninvasive invasive mechanical ventilation reported that dexamethasone 6 daily 10 days decreased 28-day (23% vs 26%). meta-analysis included 7 trials 1689 treated intensive care unit bacterial pneumonia 8 fewer was lower 30-day compared placebo (10% 16%). In trials, low-dose corticosteroids were HIV moderate (13% 25%). predefined subgroup analysis steroid treatment intravenous 50 every hours fludrocortisone μg had group (39% 51%). For syndrome caused by various conditions, in-hospital (34% 45%) according studies 1091 patients. Adverse effects include hyperglycemia, gastrointestinal bleeding, neuropsychiatric disorders, muscle weakness, hypernatremia, secondary Conclusions Relevance Treatment is infection, (for HIV). also benefit have both.

Язык: Английский

Процитировано

19
Neurovascular Pathology in Intracranial Mucormycosis: Treatment by Cranial Bypass and Literature Review DOI
Eric A. Grin, Maksim Shapiro, Eytan Raz

и другие.

Operative Neurosurgery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

BACKGROUND AND IMPORTANCE: Rhino-orbital cerebral mucormycosis (ROCM) is an aggressive fungal infection involving the paranasal sinuses, orbit, and intracranial cavity, with a propensity for vascular invasion. This can lead to complications such as internal carotid artery (ICA) thrombosis occlusion, presenting major neurosurgical challenges. Although surgical debridement antifungal therapy are mainstays of treatment, cases significant neurovascular involvement require specialized intervention. We report case ROCM severe flow-limiting ICA stenosis treated by direct extracranial-intracranial bypass. CLINICAL PRESENTATION: tA 65-year-old man diabetes presented progressive left-sided blindness facial numbness. Imaging revealed left orbital mass extending into sinuses intracranially. Empiric was started. Pathology confirmed Rhizopus species. Despite extensive therapy, patient developed cavernous stenosis, leading watershed territory strokes. To restore perfusion, protect from distal emboli, prepare potential debridement, flow-replacing (superficial temporal artery–middle (M2)) bypass performed, supraclinoid trapped. Intraoperative angiography robust flow through The discharged on aspirin. At 6-month follow-up, neurologically intact modified Rankin Scale score 1. Computed tomography transcranioplasty Doppler ultrasonography good CONCLUSION: In addition superficial be lifesaving intervention in management cerebrovascular compromise. highlights critical role cranial preserving perfusion patients ROCM-associated

Язык: Английский

Процитировано

1
Point-of-care testing for viral-associated pulmonary aspergillosis DOI
Robina Aerts, Brice Autier,

Maximilian Gornicec

и другие.

Expert Review of Molecular Diagnostics, Год журнала: 2023, Номер 24(3), С. 231 - 243

Опубликована: Сен. 9, 2023

Over the last years, severe respiratory viral infections, particularly those caused by acute syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role earlier thus improve patient outcomes.

Язык: Английский

Процитировано

18
Epidemiology, pathogenesis, clinical characteristics, and treatment of mucormycosis: a review DOI Creative Commons

Mei Liang,

Jian Xu,

Yanan Luo

и другие.

Annals of Medicine, Год журнала: 2024, Номер 56(1)

Опубликована: Сен. 2, 2024

Aim This review aims to summarize the epidemiology, etiology, pathogenesis, clinical manifestations, and current diagnostic therapeutic approaches for mucormycosis. The goal is improve understanding of mucormycosis promote early diagnosis treatment reduce mortality.

Язык: Английский

Процитировано

7
Heparin-azithromycin microparticles show anti-inflammatory effects and inhibit SARS-CoV-2 and bacterial pathogens associated to lung infections DOI
Brayan J. Anaya, Davide D’Angelo, Ruggero Bettini

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122930 - 122930

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

7
Risk factors, mortality, and predictors of survival in COVID-19-associated pulmonary mucormycosis: a multicentre retrospective study from India DOI Creative Commons
Valliappan Muthu, Ritesh Agarwal, Shivaprakash M. Rudramurthy

и другие.

Clinical Microbiology and Infection, Год журнала: 2023, Номер 30(3), С. 368 - 374

Опубликована: Дек. 9, 2023

Язык: Английский

Процитировано

17
Epidemiology, Modern Diagnostics, and the Management of Mucorales Infections DOI Creative Commons
David Pham, Annaleise R. Howard‐Jones,

Rebecca Sparks

и другие.

Journal of Fungi, Год журнала: 2023, Номер 9(6), С. 659 - 659

Опубликована: Июнь 12, 2023

Mucormycosis is an uncommon, yet deadly invasive fungal infection caused by the Mucorales moulds. These pathogens are a WHO-assigned high-priority pathogen group, as mucormycosis incidence increasing, and there unacceptably high mortality with current antifungal therapies. Current diagnostic methods have inadequate sensitivity specificity may issues accessibility or turnaround time. Patients diabetes mellitus immune compromise predisposed to these environmental fungi, but COVID-19 has established itself new risk factor. also cause healthcare-associated outbreaks, clusters associated natural disasters been identified. Robust epidemiological surveillance into burden of disease, at-risk populations, emerging required. Emerging serological molecular techniques offer faster route diagnosis, while newly developed agents show promise in preliminary studies. Equitable access therapies will be key identifying treating mucormycosis, delayed initiation therapy higher mortality.

Язык: Английский

Процитировано

15
Diagnosing fungal infections in clinical practice: a narrative review DOI
Sarah Sedik,

Stella Wolfgruber,

Martin Hoenigl

и другие.

Expert Review of Anti-infective Therapy, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Invasive fungal infections (IFI) present a major medical challenge, with an estimated 6.5 million cases annually, resulting in 3.8 deaths. Pathogens such as Aspergillus spp. Candida Mucorales Cryptococcus and other fungi species contribute to these infections, posing risks immunocompromised individuals. Early accurate diagnosis is crucial for effective treatment better patient outcomes.

Язык: Английский

Процитировано

5