Mucormycosis
is
a
severe,
opportunistic
infection
caused
by
Mucorales,
taxonomical
group
of
thermotolerant
fungi
primarily
affecting
the
immunocompromised.
Intra-abdominal
involvement
in
mucormycosis
rare
entity,
particularly
immunocompetent
individuals.
We
present
fatal
case
gallbladder
and
renal
an
female,
leading
to
septic
shock
death.
The
diagnosis
was
confirmed
via
histopathology
following
cholecystectomy
for
suspected
gangrenous
cholecystitis
open
right
nephrectomy
due
kidney
infarction.
Quantitative
polymerase
chain
reaction
tissue
identified
presence
Apophysomyces
ossiformis.
clinical
picture
confounded
ongoing
sepsis
Klebsiella
pneumoniae-infected
retroperitoneal
hematoma,
non-specific
imaging
findings,
absence
traditional
risk
factors
mucormycosis,
delayed
diagnosis.
Despite
surgical
debridement,
initiation
liposomal
amphotericin
B
with
posaconazole,
aggressive
treatment
intensive
care
unit,
patient
succumbed
complications
mucormycosis.
adequate
antibiotic
coverage,
this
underscores
importance
considering
Mucorales
otherwise
patients
deteriorating
condition.
Early
appropriate
intervention
are
essential
enhancing
survivability,
though
mortality
rates
remain
high
severe
cases.
Clinical Microbiology Reviews,
Год журнала:
2023,
Номер
36(3)
Опубликована: Июль 13, 2023
Fungal
endocarditis
accounts
for
1%
to
3%
of
all
infective
cases,
is
associated
with
high
morbidity
and
mortality
(>70%),
presents
numerous
challenges
during
clinical
care.
Candida
spp.
are
the
most
common
causes
fungal
endocarditis,
implicated
in
over
50%
followed
by
Aspergillus
Histoplasma
Important
risk
factors
include
prosthetic
valves,
prior
heart
surgery,
injection
drug
use.
The Lancet Microbe,
Год журнала:
2024,
Номер
5(7), С. 717 - 724
Опубликована: Апрель 9, 2024
In
October,
2022,
WHO
published
the
first
fungal
priority
pathogen
list,
which
categorised
19
entities
into
three
groups
(critical,
high,
and
medium),
for
prioritisation
of
research
efforts.
The
final
ranking
was
determined
via
multiple
criteria
decision
analysis,
considering
both
development
needs
perceived
public
health
importance.
this
Personal
View,
we
discuss
positioning
pathogens,
namely,
Mucorales,
Candida
spp,
Histoplasma
Coccidioides
Paracoccidioides
Fusarium
eumycetoma
causative
agents,
Talaromyces
marneffei,
Pneumocystis
jirovecii,
while
expressing
concerns
about
potential
disparities
between
list
actual
disease
burden
associated
with
these
pathogens.
Finally,
propose
a
revised
that
also
considers
regional
in
diseases.
JAMA,
Год журнала:
2024,
Номер
332(4), С. 318 - 318
Опубликована: Июнь 12, 2024
Importance
Severe
pulmonary
infections,
including
COVID-19,
community-acquired
pneumonia,
influenza,
and
Pneumocystis
are
a
leading
cause
of
death
among
adults
worldwide.
Pulmonary
infections
in
critically
ill
patients
may
septic
shock,
acute
respiratory
distress
syndrome,
or
both,
which
associated
with
mortality
rates
ranging
between
30%
50%.
Observations
Corticosteroids
mitigate
the
immune
response
to
infection
improve
outcomes
for
several
types
severe
infections.
Low-dose
corticosteroids,
defined
as
less
than
equal
400
mg
hydrocortisone
equivalent
daily,
can
reduce
pneumonia.
A
randomized
clinical
trial
6425
hospitalized
COVID-19
who
required
supplemental
oxygen
noninvasive
invasive
mechanical
ventilation
reported
that
dexamethasone
6
daily
10
days
decreased
28-day
(23%
vs
26%).
meta-analysis
included
7
trials
1689
treated
intensive
care
unit
bacterial
pneumonia
8
fewer
was
lower
30-day
compared
placebo
(10%
16%).
In
trials,
low-dose
corticosteroids
were
HIV
moderate
(13%
25%).
predefined
subgroup
analysis
steroid
treatment
intravenous
50
every
hours
fludrocortisone
μg
had
group
(39%
51%).
For
syndrome
caused
by
various
conditions,
in-hospital
(34%
45%)
according
studies
1091
patients.
Adverse
effects
include
hyperglycemia,
gastrointestinal
bleeding,
neuropsychiatric
disorders,
muscle
weakness,
hypernatremia,
secondary
Conclusions
Relevance
Treatment
is
infection,
(for
HIV).
also
benefit
have
both.
Operative Neurosurgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
BACKGROUND
AND
IMPORTANCE:
Rhino-orbital
cerebral
mucormycosis
(ROCM)
is
an
aggressive
fungal
infection
involving
the
paranasal
sinuses,
orbit,
and
intracranial
cavity,
with
a
propensity
for
vascular
invasion.
This
can
lead
to
complications
such
as
internal
carotid
artery
(ICA)
thrombosis
occlusion,
presenting
major
neurosurgical
challenges.
Although
surgical
debridement
antifungal
therapy
are
mainstays
of
treatment,
cases
significant
neurovascular
involvement
require
specialized
intervention.
We
report
case
ROCM
severe
flow-limiting
ICA
stenosis
treated
by
direct
extracranial-intracranial
bypass.
CLINICAL
PRESENTATION:
tA
65-year-old
man
diabetes
presented
progressive
left-sided
blindness
facial
numbness.
Imaging
revealed
left
orbital
mass
extending
into
sinuses
intracranially.
Empiric
was
started.
Pathology
confirmed
Rhizopus
species.
Despite
extensive
therapy,
patient
developed
cavernous
stenosis,
leading
watershed
territory
strokes.
To
restore
perfusion,
protect
from
distal
emboli,
prepare
potential
debridement,
flow-replacing
(superficial
temporal
artery–middle
(M2))
bypass
performed,
supraclinoid
trapped.
Intraoperative
angiography
robust
flow
through
The
discharged
on
aspirin.
At
6-month
follow-up,
neurologically
intact
modified
Rankin
Scale
score
1.
Computed
tomography
transcranioplasty
Doppler
ultrasonography
good
CONCLUSION:
In
addition
superficial
be
lifesaving
intervention
in
management
cerebrovascular
compromise.
highlights
critical
role
cranial
preserving
perfusion
patients
ROCM-associated
Expert Review of Molecular Diagnostics,
Год журнала:
2023,
Номер
24(3), С. 231 - 243
Опубликована: Сен. 9, 2023
Over
the
last
years,
severe
respiratory
viral
infections,
particularly
those
caused
by
acute
syndrome
coronavirus
2
(SARS-CoV-2)
and
influenza
virus,
have
emerged
as
risk
factor
for
viral-associated
pulmonary
aspergillosis
(VAPA)
among
critically
ill
patients.
Delays
in
diagnosis
of
VAPA
are
associated
with
increased
mortality.
Point-of-care-tests
may
play
an
important
role
earlier
thus
improve
patient
outcomes.
Annals of Medicine,
Год журнала:
2024,
Номер
56(1)
Опубликована: Сен. 2, 2024
Aim
This
review
aims
to
summarize
the
epidemiology,
etiology,
pathogenesis,
clinical
manifestations,
and
current
diagnostic
therapeutic
approaches
for
mucormycosis.
The
goal
is
improve
understanding
of
mucormycosis
promote
early
diagnosis
treatment
reduce
mortality.
Journal of Fungi,
Год журнала:
2023,
Номер
9(6), С. 659 - 659
Опубликована: Июнь 12, 2023
Mucormycosis
is
an
uncommon,
yet
deadly
invasive
fungal
infection
caused
by
the
Mucorales
moulds.
These
pathogens
are
a
WHO-assigned
high-priority
pathogen
group,
as
mucormycosis
incidence
increasing,
and
there
unacceptably
high
mortality
with
current
antifungal
therapies.
Current
diagnostic
methods
have
inadequate
sensitivity
specificity
may
issues
accessibility
or
turnaround
time.
Patients
diabetes
mellitus
immune
compromise
predisposed
to
these
environmental
fungi,
but
COVID-19
has
established
itself
new
risk
factor.
also
cause
healthcare-associated
outbreaks,
clusters
associated
natural
disasters
been
identified.
Robust
epidemiological
surveillance
into
burden
of
disease,
at-risk
populations,
emerging
required.
Emerging
serological
molecular
techniques
offer
faster
route
diagnosis,
while
newly
developed
agents
show
promise
in
preliminary
studies.
Equitable
access
therapies
will
be
key
identifying
treating
mucormycosis,
delayed
initiation
therapy
higher
mortality.
Expert Review of Anti-infective Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Invasive
fungal
infections
(IFI)
present
a
major
medical
challenge,
with
an
estimated
6.5
million
cases
annually,
resulting
in
3.8
deaths.
Pathogens
such
as
Aspergillus
spp.
Candida
Mucorales
Cryptococcus
and
other
fungi
species
contribute
to
these
infections,
posing
risks
immunocompromised
individuals.
Early
accurate
diagnosis
is
crucial
for
effective
treatment
better
patient
outcomes.