Опубликована: Янв. 1, 2024

Multidrug-resistant bacteria are among the most challenges in healthcare systems. According to World Health Organization, these that belong critical and high-priority groups resistant carbapenem or multiple antibiotics, respectively. They commonly associated with bone, skin, soft tissue infections, current treatment strategies involve use of oral intravenous antibiotics. Consequently, infected injured sites benefit from combined antimicrobial regenerative action during tissues' repair. The high demand for effective solutions led development biocompatible antibacterial polymeric membranes local therapy. These highly porous composed by nanofibers' network providing a matrix cellular proliferation release agents. Nowadays, there several techniques produce nanofibers like template synthesis, self-assembly, freeze-drying, melt-blowing, electrospinning, others. Electrospinning emerges production intrinsic characteristics. surface area-to-volume ratio nanometric diameters allow mimicking innate tissues increasing biomedical fields' attention. Therefore, electrospun become favoured as drug delivery systems, improving drugs' dissolution rates while maximizing their action. Additionally, they permits loading drugs higher concentrations control rate without toxicity. Hence, antibiotics have been common encapsulated medicinal compounds using numerous polymers combinations carriers. versatility electrospinning advanced approaches which combine complex locally provide agents through same platform consider different profiles. Overall, further developments should continue systems meet clinical requirements.

Язык: Английский