Bias-accounting meta-analyses overcome cerebellar neglect to refine the cerebellar behavioral topography DOI Creative Commons
Neville Magielse, Aikaterina Manoli, Simon B. Eickhoff

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Abstract The cerebellum plays important roles in motor, cognitive, and emotional behaviors. Previous cerebellar coordinate-based meta-analyses mappings have attributed different behaviors to subareas, but an accurate behavioral topography is lacking. Here, we show overrepresentation of superior activation foci, which may be exacerbated by historical neglect. Unequal foci distributions render the null hypothesis standard likelihood estimation unsuitable. Our new method, cerebellum-specific activation-likelihood (C-SALE), finds convergence beyond baseline rates. It does this testing experimental versus models sampled from a data-driven, biased probability distribution finding at any location. Cerebellar were made across five BrainMap task domains thirty-five subdomains, illustrating improved specificity method. Twelve forty (sub)domains reached specific subregions, supporting dual motor representations placing cognition posterior-lateral regions. Repeated subsampling revealed that whereas action, language working memory relatively stable, other produced unstable meta-analytic maps. Lastly, connectivity modeling same debiased framework was used reveal coactivation networks clusters. In sum, created method for meta-analysis accounts data biases can flexibly adapted part brain. findings provide refined understanding involvement human behaviors, highlighting regions future investigation both basic clinical applications.

Язык: Английский

Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice DOI Creative Commons
Meike E. van der Heijden

The Cerebellum, Год журнала: 2024, Номер 23(5), С. 1754 - 1767

Опубликована: Май 23, 2024

Abstract Evidence from clinical and preclinical studies has shown that the cerebellum contributes to cognitive functions, including social behaviors. Now cerebellum’s role in a wider range of behaviors been confirmed, question arises whether via same mechanisms with which it modulates movements. This review seeks answer guides motor through identical pathways. It focuses on cerebellar cells, synapses, or genes are manipulated cell-type specific manner followed by testing effects These show both anatomically restricted cortex-wide manipulations can lead impairments without abnormal control, vice versa. suggest employs different cellular, synaptic, molecular pathways for Future warrant focus diverging wide neural functions.

Язык: Английский

Процитировано

6
Cerebellar Roles in Motor and Social Functions and Implications for ASD DOI
Azhagu Madhavan Sivalingam, Arjun Pandian

The Cerebellum, Год журнала: 2024, Номер 23(6), С. 2564 - 2574

Опубликована: Июль 17, 2024

Язык: Английский

Процитировано

4
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling DOI Open Access
Da Guo, Marylka Yoe Uusisaari

Опубликована: Фев. 27, 2025

Complex spikes (CSs), generated by inferior olive (IO) neurons, are foundational to most theories of cerebellar function and motor learning. Despite their importance, recordings from IO neurons in living animals have been limited single-electrode methods, providing no insights into multineuron dynamics within intact circuits. Here, we used a novel ventral surgical approach that allows calcium imaging-based monitoring multicellular activity the anesthetized mice. This method provides direct optical access medulla, enabling simultaneous recording spontaneous sensory-evoked localized clusters specifically principal (PO) dorsal accessory olives (DAO).Our findings reveal rates event magnitudes differ between PO DAO, consistent with observations cortex zebrin-positive (Z+) zebrin-negative (Z-) zones, respectively. We further demonstrate amplitudes influenced co-activation among neighboring so events occurring larger than single ones. Event is more pronounced potentially explaining differences complex spike sizes observed Z+ Z-zones. Sensory-evoked induced periocular airpuff stimulation were ones, as expected. However, this difference diminishes when accounting for higher levels during sensory stimulation. By comparing categorized clustered or single, find intrinsic amplitudes, emphasizing role shaping magnitude. Next, optogenetically activated nucleo-olivary (N-O) axons, pathway central CS generation. To our surprise, while robustly suppressed activity, showed reduction either probability waveform. Our suggest traditional view N-O purely inhibitory desynchronizing might be complemented selective suppression background preserving sensory-driven responses. Together local magnitudes, work offers new insight timing variation functional significance behavior.

Язык: Английский

Процитировано

0
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling DOI Open Access
Da Guo, Marylka Yoe Uusisaari

Опубликована: Фев. 27, 2025

Complex spikes (CSs), generated by inferior olive (IO) neurons, are foundational to most theories of cerebellar function and motor learning. Despite their importance, recordings from IO neurons in living animals have been limited single-electrode methods, providing no insights into multineuron dynamics within intact circuits. Here, we used a novel ventral surgical approach that allows calcium imaging-based monitoring multicellular activity the anesthetized mice. This method provides direct optical access medulla, enabling simultaneous recording spontaneous sensory-evoked localized clusters specifically principal (PO) dorsal accessory olives (DAO).Our findings reveal rates event magnitudes differ between PO DAO, consistent with observations cortex zebrin-positive (Z+) zebrin-negative (Z-) zones, respectively. We further demonstrate amplitudes influenced co-activation among neighboring so events occurring larger than single ones. Event is more pronounced potentially explaining differences complex spike sizes observed Z+ Z-zones. Sensory-evoked induced periocular airpuff stimulation were ones, as expected. However, this difference diminishes when accounting for higher levels during sensory stimulation. By comparing categorized clustered or single, find intrinsic amplitudes, emphasizing role shaping magnitude. Next, optogenetically activated nucleo-olivary (N-O) axons, pathway central CS generation. To our surprise, while robustly suppressed activity, showed reduction either probability waveform. Our suggest traditional view N-O purely inhibitory desynchronizing might be complemented selective suppression background preserving sensory-driven responses. Together local magnitudes, work offers new insight timing variation functional significance behavior.

Язык: Английский

Процитировано

0
Editorial overview: Role of the cerebellum in cognition and behavior DOI
Wietske van der Zwaag,

Sheeba Arnold Anteraper

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 60, С. 101444 - 101444

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

1
Bias-accounting meta-analyses overcome cerebellar neglect to refine the cerebellar behavioral topography DOI Creative Commons
Neville Magielse, Aikaterina Manoli, Simon B. Eickhoff

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Abstract The cerebellum plays important roles in motor, cognitive, and emotional behaviors. Previous cerebellar coordinate-based meta-analyses mappings have attributed different behaviors to subareas, but an accurate behavioral topography is lacking. Here, we show overrepresentation of superior activation foci, which may be exacerbated by historical neglect. Unequal foci distributions render the null hypothesis standard likelihood estimation unsuitable. Our new method, cerebellum-specific activation-likelihood (C-SALE), finds convergence beyond baseline rates. It does this testing experimental versus models sampled from a data-driven, biased probability distribution finding at any location. Cerebellar were made across five BrainMap task domains thirty-five subdomains, illustrating improved specificity method. Twelve forty (sub)domains reached specific subregions, supporting dual motor representations placing cognition posterior-lateral regions. Repeated subsampling revealed that whereas action, language working memory relatively stable, other produced unstable meta-analytic maps. Lastly, connectivity modeling same debiased framework was used reveal coactivation networks clusters. In sum, created method for meta-analysis accounts data biases can flexibly adapted part brain. findings provide refined understanding involvement human behaviors, highlighting regions future investigation both basic clinical applications.

Язык: Английский

Процитировано

1