Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice
The Cerebellum,
Год журнала:
2024,
Номер
23(5), С. 1754 - 1767
Опубликована: Май 23, 2024
Abstract
Evidence
from
clinical
and
preclinical
studies
has
shown
that
the
cerebellum
contributes
to
cognitive
functions,
including
social
behaviors.
Now
cerebellum’s
role
in
a
wider
range
of
behaviors
been
confirmed,
question
arises
whether
via
same
mechanisms
with
which
it
modulates
movements.
This
review
seeks
answer
guides
motor
through
identical
pathways.
It
focuses
on
cerebellar
cells,
synapses,
or
genes
are
manipulated
cell-type
specific
manner
followed
by
testing
effects
These
show
both
anatomically
restricted
cortex-wide
manipulations
can
lead
impairments
without
abnormal
control,
vice
versa.
suggest
employs
different
cellular,
synaptic,
molecular
pathways
for
Future
warrant
focus
diverging
wide
neural
functions.
Язык: Английский
Cerebellar Roles in Motor and Social Functions and Implications for ASD
The Cerebellum,
Год журнала:
2024,
Номер
23(6), С. 2564 - 2574
Опубликована: Июль 17, 2024
Язык: Английский
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling
Опубликована: Фев. 27, 2025
Complex
spikes
(CSs),
generated
by
inferior
olive
(IO)
neurons,
are
foundational
to
most
theories
of
cerebellar
function
and
motor
learning.
Despite
their
importance,
recordings
from
IO
neurons
in
living
animals
have
been
limited
single-electrode
methods,
providing
no
insights
into
multineuron
dynamics
within
intact
circuits.
Here,
we
used
a
novel
ventral
surgical
approach
that
allows
calcium
imaging-based
monitoring
multicellular
activity
the
anesthetized
mice.
This
method
provides
direct
optical
access
medulla,
enabling
simultaneous
recording
spontaneous
sensory-evoked
localized
clusters
specifically
principal
(PO)
dorsal
accessory
olives
(DAO).Our
findings
reveal
rates
event
magnitudes
differ
between
PO
DAO,
consistent
with
observations
cortex
zebrin-positive
(Z+)
zebrin-negative
(Z-)
zones,
respectively.
We
further
demonstrate
amplitudes
influenced
co-activation
among
neighboring
so
events
occurring
larger
than
single
ones.
Event
is
more
pronounced
potentially
explaining
differences
complex
spike
sizes
observed
Z+
Z-zones.
Sensory-evoked
induced
periocular
airpuff
stimulation
were
ones,
as
expected.
However,
this
difference
diminishes
when
accounting
for
higher
levels
during
sensory
stimulation.
By
comparing
categorized
clustered
or
single,
find
intrinsic
amplitudes,
emphasizing
role
shaping
magnitude.
Next,
optogenetically
activated
nucleo-olivary
(N-O)
axons,
pathway
central
CS
generation.
To
our
surprise,
while
robustly
suppressed
activity,
showed
reduction
either
probability
waveform.
Our
suggest
traditional
view
N-O
purely
inhibitory
desynchronizing
might
be
complemented
selective
suppression
background
preserving
sensory-driven
responses.
Together
local
magnitudes,
work
offers
new
insight
timing
variation
functional
significance
behavior.
Язык: Английский
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling
Опубликована: Фев. 27, 2025
Complex
spikes
(CSs),
generated
by
inferior
olive
(IO)
neurons,
are
foundational
to
most
theories
of
cerebellar
function
and
motor
learning.
Despite
their
importance,
recordings
from
IO
neurons
in
living
animals
have
been
limited
single-electrode
methods,
providing
no
insights
into
multineuron
dynamics
within
intact
circuits.
Here,
we
used
a
novel
ventral
surgical
approach
that
allows
calcium
imaging-based
monitoring
multicellular
activity
the
anesthetized
mice.
This
method
provides
direct
optical
access
medulla,
enabling
simultaneous
recording
spontaneous
sensory-evoked
localized
clusters
specifically
principal
(PO)
dorsal
accessory
olives
(DAO).Our
findings
reveal
rates
event
magnitudes
differ
between
PO
DAO,
consistent
with
observations
cortex
zebrin-positive
(Z+)
zebrin-negative
(Z-)
zones,
respectively.
We
further
demonstrate
amplitudes
influenced
co-activation
among
neighboring
so
events
occurring
larger
than
single
ones.
Event
is
more
pronounced
potentially
explaining
differences
complex
spike
sizes
observed
Z+
Z-zones.
Sensory-evoked
induced
periocular
airpuff
stimulation
were
ones,
as
expected.
However,
this
difference
diminishes
when
accounting
for
higher
levels
during
sensory
stimulation.
By
comparing
categorized
clustered
or
single,
find
intrinsic
amplitudes,
emphasizing
role
shaping
magnitude.
Next,
optogenetically
activated
nucleo-olivary
(N-O)
axons,
pathway
central
CS
generation.
To
our
surprise,
while
robustly
suppressed
activity,
showed
reduction
either
probability
waveform.
Our
suggest
traditional
view
N-O
purely
inhibitory
desynchronizing
might
be
complemented
selective
suppression
background
preserving
sensory-driven
responses.
Together
local
magnitudes,
work
offers
new
insight
timing
variation
functional
significance
behavior.
Язык: Английский
Editorial overview: Role of the cerebellum in cognition and behavior
Current Opinion in Behavioral Sciences,
Год журнала:
2024,
Номер
60, С. 101444 - 101444
Опубликована: Сен. 11, 2024
Язык: Английский
Bias-accounting meta-analyses overcome cerebellar neglect to refine the cerebellar behavioral topography
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
The
cerebellum
plays
important
roles
in
motor,
cognitive,
and
emotional
behaviors.
Previous
cerebellar
coordinate-based
meta-analyses
mappings
have
attributed
different
behaviors
to
subareas,
but
an
accurate
behavioral
topography
is
lacking.
Here,
we
show
overrepresentation
of
superior
activation
foci,
which
may
be
exacerbated
by
historical
neglect.
Unequal
foci
distributions
render
the
null
hypothesis
standard
likelihood
estimation
unsuitable.
Our
new
method,
cerebellum-specific
activation-likelihood
(C-SALE),
finds
convergence
beyond
baseline
rates.
It
does
this
testing
experimental
versus
models
sampled
from
a
data-driven,
biased
probability
distribution
finding
at
any
location.
Cerebellar
were
made
across
five
BrainMap
task
domains
thirty-five
subdomains,
illustrating
improved
specificity
method.
Twelve
forty
(sub)domains
reached
specific
subregions,
supporting
dual
motor
representations
placing
cognition
posterior-lateral
regions.
Repeated
subsampling
revealed
that
whereas
action,
language
working
memory
relatively
stable,
other
produced
unstable
meta-analytic
maps.
Lastly,
connectivity
modeling
same
debiased
framework
was
used
reveal
coactivation
networks
clusters.
In
sum,
created
method
for
meta-analysis
accounts
data
biases
can
flexibly
adapted
part
brain.
findings
provide
refined
understanding
involvement
human
behaviors,
highlighting
regions
future
investigation
both
basic
clinical
applications.
Язык: Английский