Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1468 - 1468
Опубликована: Ноя. 18, 2024
This
review
explores
the
potential
of
peptide-based
biomaterials
to
enhance
biomedical
applications
through
self-assembly,
biological
responsiveness,
and
selective
targeting.
Peptides
are
presented
as
versatile
agents
for
antimicrobial
activity
drug
delivery,
with
recent
approaches
incorporating
peptides
into
self-assembling
systems
improve
effectiveness
reduce
resistance.
The
also
covers
nanocarriers
cancer
highlighting
their
improved
stability,
targeted
reduced
side
effects.
focus
this
work
is
on
bioactive
properties
peptides,
particularly
in
infection
control
rather
than
structural
design
or
material
characteristics.
Additionally,
it
examines
role
peptidomimetics
broadening
biomaterial
enhancing
resistance
enzymatic
degradation.
Finally,
discusses
commercial
prospects
challenges
translating
peptide
clinical
applications.
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(4), С. 2381 - 2391
Опубликована: Фев. 9, 2024
Epidemics
such
as
pulmonary
tuberculosis
and
pertussis
can
spread
quickly
through
the
air
in
enclosed
or
small
spaces.
Most
of
these
diseases
are
caused
by
various
bacteria.
In
hospitals,
nursing
homes,
biology
laboratories,
requirement
for
quality
is
often
high.
Particulate
filters
remove
infectious
bacteria
from
air,
making
them
a
good
choice
local
ventilation
systems
to
capture
other
pathogenic
microbes.
With
high
surface
area,
electrospun
poly(l-lactic
acid)
(PLLA)
fibrous
membranes
have
ability
particles
like
Moreover,
copper
has
significant
antimicrobial
properties.
this
Letter,
we
present
hierarchically
porous
PLLA
membrane
created
electrospinning
acetone
treatment.
Additionally,
describe
two
methods
loading
onto
membrane,
thereby
providing
capabilities
capturing
killing
The
experiments
demonstrated
that
final
PLLA/Cu
composite
exhibit
not
only
excellent
permeability
but
also
remarkable
performance
while
maintaining
bendability
superhydrophobic
ability.
This
study
provides
simple
process,
low
energy
cost,
environmentally
friendly
method
produce
copper-coated
which
especially
suitable
potential
applications
high-flux
filtration
equipment
laboratories.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(20)
Опубликована: Июль 5, 2024
Abstract
Amphiphilic
peptides
have
garnered
significant
attention
due
to
their
highly
designable
and
self‐assembling
behaviors.
Self‐assembled
hold
excellent
potential
in
various
fields
such
as
biosensing,
environmental
monitoring,
drug
delivery,
owing
remarkable
biological,
physical,
chemical
properties.
While
nanomaterials
formed
by
peptide
self‐assembly
found
widespread
use
biomedical
applications,
the
development
of
2D
nanosheets
based
on
amphiphilic
remains
challenging
terms
rational
design
morphology
modulation.
In
this
study,
rationally
designed
molecules
are
self‐assembled
into
(PNS)
under
specific
conditions
encapsulate
gold
nanoparticles
(AuNPs),
resulting
formation
AuNPs/PNS
hybrid
materials
with
high
photothermal
conversion
efficiency.
The
findings
demonstrate
that
PNS
enhances
overall
therapy
effect
nanohybrid
larger
hosting
area
for
AuNPs
higher
biocompatibility.
well‐designed
study
offer
insights
structural
functional
modulation
molecules.
addition,
constructed
biomimetic‐functional
inorganic/organic
applications
engineering.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
7(8), С. 4962 - 4974
Опубликована: Дек. 20, 2023
Nanotechnological
interventions
for
cancer
immunotherapy
are
a
rapidly
evolving
paradigm
with
immense
potential.
Self-assembled
nanobiomaterials
present
safer
alternatives
to
their
nondegradable
counterparts
and
pose
better
functionalities
in
terms
of
controlled
drug
delivery
phototherapy
activate
immunogenic
cell
death.
In
this
Review,
we
discuss
several
classes
self-assembled
based
on
polymers,
lipids,
peptides,
hydrogel,
metal
organic
frameworks,
covalent–organic
frameworks
the
ability
systemic
immune
response
convert
"cold"
immunosuppressive
tumor
mass
"hot"
antitumor
rich
microenvironment.
The
unique
aspects
these
materials
underpinned,
mechanisms
combinatorial
immunotherapeutic
action
discussed.
Future
challenges
associated
clinical
translation
also
highlighted.
The
biological
properties
of
antimicrobial
peptides
(AMPs)
and
amyloid
proteins
their
cross-talks
have
gained
increasing
attention
due
to
potential
implications
in
both
host
defense
mechanisms
amyloid-related
diseases.
However,
complex
interactions,
molecular
mechanisms,
physiological
applications
are
not
fully
understood.
interplay
between
is
crucial
for
uncovering
new
insights
into
immune
disease
bridging
critical
gaps
understanding
infectious
neurodegenerative
This
review
provides
an
overview
the
cross-talk
AMPs
amyloids,
highlighting
intricate
interplay,
action,
therapeutic
implications.
dual
roles
AMPs,
which
only
serve
as
key
components
innate
system,
combating
microbial
infections,
but
also
exhibit
modulatory
effects
on
formation
toxicity,
discussed.
diverse
employed
by
modulate
aggregation,
fibril
formation,
toxicity
Additionally,
we
explore
emerging
evidence
suggesting
that
may
possess
properties,
adding
a
dimension
relationship
amyloids.
underscores
importance
amyloids
better
understand
processes
underlying
diseases
disorders
aid
development
avenues
treat
them.
Journal of Colloid and Interface Science,
Год журнала:
2023,
Номер
659, С. 397 - 412
Опубликована: Дек. 28, 2023
Clinical
treatments
ofgastric
infections
using
antibiotics
suffer
from
the
undesired
killing
of
commensal
bacteria
and
emergence
antibiotic
resistance.
It
is
desirable
to
develop
pH-responsive
antimicrobial
peptides
(AMPs)
that
kill
pathogenic
such
as
H.
pyloriand
resistant
E.
coli
under
acidic
environment
with
minimal
impact
whilst
not
causing
