Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

The Annual Review of Pharmacology and Toxicology, Год журнала: 2020, Номер 60(1), С. 241 - 255

Опубликована: Янв. 6, 2020

Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably bees. Enhanced resistance neonicotinoids in is becoming well documented. We address current understanding of neonicotinoid target site interactions, selectivity, metabolism not only also beneficial insects such as The findings relevant management both new generation pesticides targeting nicotinic acetylcholine receptors.

Язык: Английский

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Electrochemical Biosensors for Detection of Pesticides and Heavy Metal Toxicants in Water: Recent Trends and Progress

ACS ES&T Water, Год журнала: 2021, Номер 1(3), С. 462 - 478

Опубликована: Фев. 15, 2021

The release of chemicals into water systems has resulted in pollution many parts the world, threatening human health and aquatic ecosystems. Sources chemical discharge include industry, agricultural, wastewater treatment plants, stormwater overflows. To combat pollution, European Union introduced several directives that set concentration limits for drinking water, surface groundwater. meet these limits, it is essential rapid, reliable, sensitive analytical detection be developed put use. This Review presents progress made development electrochemical biosensors environmental toxicants (pesticides heavy metals) over past seven years (2014–2020). For those unfamiliar with this field research, concept a biosensor followed by critical evaluation their performance detecting toxicants. Current challenges are discussed as well potential avenues future including demands enhanced performance, improved stability shelf life, greater integration microfluidic devices wireless database technologies remote sensing applications. We believe will beneficial enhance awareness appreciation role can play protecting our environment resources.

Язык: Английский

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The Buzz on Insecticides: A Review of Uses, Molecular Structures, Targets, Adverse Effects, and Alternatives

Molecules, Год журнала: 2023, Номер 28(8), С. 3641 - 3641

Опубликована: Апрель 21, 2023

Insecticides play a critical role in controlling the spread of insect-borne diseases and preserving crop health. These chemical substances are specifically formulated to kill or manage insect populations. Over years, various types insecticides have been developed, including organophosphates, carbamates, pyrethroids, neonicotinoids, each with unique modes action, physiological targets, efficacy. Despite advantages that offer, it is imperative recognize potential consequences on non-target species, environment, human It therefore crucial follow recommended label instructions employ integrated pest management practices for judicious use insecticides. This review article provides an in-depth examination insecticides, their environmental health impacts, alternatives. The aim furnish comprehensive overview emphasize significance responsible sustainable utilization.

Язык: Английский

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Results from the Egyptian monitoring programme and dietary risk assessment for pesticide residues in fruits during the period of 2018–2021

International Journal of Environmental & Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Фев. 24, 2025

Язык: Английский

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Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids

Biosensors, Год журнала: 2019, Номер 9(1), С. 20 - 20

Опубликована: Фев. 4, 2019

Pesticides, due to their intensive use and peculiar chemical features, can persist in the environment enter trophic chain, thus representing an environmental risk for ecosystems human health. Although there are several robust reliable standard analytical techniques monitoring, high frequency of contamination caused by pesticides requires methods massive monitoring campaigns that capable rapidly detecting these compounds many samples different origin. Immunosensors represent a potential tool simple, rapid, sensitive pesticides. Antibodies coupled electrochemical or optical transducers have resulted effective detection devices. In this review, new trends immunosensor development application immunosensors concern-such as glyphosate, organophosphates, neonicotinoids-are described.

Язык: Английский

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Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 117(28), С. 16283 - 16291

Опубликована: Июль 1, 2020

Significance Neonicotinoids acting on insect nicotinic acetylcholine receptors (nAChRs) are deployed for crop protection, but growing evidence adverse effects pollinators has led to restricted use of some neonicotinoids in the EU. It is therefore vital understand target site actions pollinators, date difficulties heterologous expression nAChRs have hampered progress. We found that a thioredoxin (TMX3) enables robust functional honeybee, bumblebee, and fruit fly Xenopus laevis oocytes. With this advance, we show expressed bee more neonicotinoid-sensitive than those fly, clothianidin can modulate both honeybee bumblebee at concentration below commonly observed agricultural fields.

Язык: Английский

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Pesticide contamination in agro-ecosystems: toxicity, impacts, and bio-based management strategies

Environmental Science and Pollution Research, Год журнала: 2022, Номер 30(4), С. 9243 - 9270

Опубликована: Дек. 2, 2022

Язык: Английский

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Neonicotinoid insecticides in the environment: A critical review of their distribution, transport, fate, and toxic effects

Journal of environmental chemical engineering, Год журнала: 2022, Номер 10(5), С. 108485 - 108485

Опубликована: Авг. 24, 2022

Язык: Английский

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A comprehensive review on the pretreatment and detection methods of neonicotinoid insecticides in food and environmental samples

Food Chemistry X, Год журнала: 2022, Номер 15, С. 100375 - 100375

Опубликована: Июнь 22, 2022

In recent years, the residues of neonicotinoid insecticide in food and environmental samples have attracted extensive attention. Neonicotinoids many adverse effects on human health, such as cancer, chronic disease, birth defects, infertility. They substantial toxicity to some non-target organisms (especially bees). Hence, monitoring insecticides foodstuffs is necessary guarantee public health ecological stability. This review aims summarize assess metabolic features, residue status, sample pretreatment methods (solid-phase extraction (SPE), Quick, Easy, Cheap, Effective, Rugged, Safe (QuEChERS), novel methods), detection (instrument detection, immunoassay, innovative methods) for samples. provides detailed references discussion analysis residues, which can effectively promote establishment residues.

Язык: Английский

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Cyto‐Genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

ABSTRACT Sulfoxaflor (SFX) is an insecticide that commonly used for the control of sap‐feeding insects. Since SFX extensively applied globally, it has been implicated in substantial induction environmental toxicity. Therefore, this study, Allium cepa roots have employed to elucidate potential cytogenotoxic effects non‐target cells by examination mitotic index (MI), chromosomal aberrations (CAs), and DNA damage. Physiological were evaluated A. root growth inhibition assay, while assessed ana‐telophase comet assay. Moreover, binding affinity mode examined using molecular docking simulations shed light on genotoxic mechanism action. The half maximal effective concentration (EC 50 ) calculated was found as 500 mg/L. dose‐ time‐dependent decrease MI, increase CAs (disturbed ana‐telophase, laggards, stickiness, anaphase chromosome bridge) damage observed exposure tips after 24‐, 48‐, 72‐, 96‐h treatment periods. A 6‐bp double‐stranded structure containing two intercalation sites (PDB ID: 1Z3F) studies. According results, exhibited energetically more favorable with (Δ G = −5.05 kcal/mol) compared experimental mutagen methyl methanesulfonate (MMS) −2.94 kcal/mol), preferentially snugly fits into minor groove possessing gap, thus, providing valuable mechanistic data formation fragmentation induced pesticide .

Язык: Английский

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