Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes DOI Creative Commons
Michael Gilbert, Karl M. Glastad,

Maxxum Fioriti

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

ABSTRACT Social insects offer powerful models to investigate the mechanistic foundation of elaborate individual behaviors comprising a cooperative community. Workers leafcutter ant genus Atta provide an extreme example behavioral segregation among many phenotypically distinct worker types. We utilize complex system cephalotes test molecular underpinnings programming and, in particular, extent plasticity reprogramming. identify specific neuropeptides as mediators division labor A. , finding two associated with characteristic leafcutting and brood care. Manipulation via genetic knockdown or by injection these led stark loss gain each behavior transcriptomic shifts predicted direction, that is, towards gene pathways expressed natural caste. also compare transcriptomes those orthologous workers eusocial mammal, naked mole rat H. gaber revealing global similarities between caste-biased expression link roles our studied ants. This work underscores essential function establishing social remarkable

Язык: Английский

Pheromone representation in the ant antennal lobe changes with age DOI Creative Commons
Taylor Hart,

Lindsey E. Lopes,

Dominic D. Frank

и другие.

Current Biology, Год журнала: 2024, Номер 34(14), С. 3233 - 3240.e4

Опубликована: Июнь 13, 2024

While the neural basis of age-related decline has been extensively studied,1Damoiseaux J.S. Effects aging on functional and structural brain connectivity.Neuroimage. 2017; 160: 32-40https://doi.org/10.1016/j.neuroimage.2017.01.077Crossref PubMed Scopus (348) Google Scholar,2Tamura T. Chiang A.-S. Ito N. Liu H.-P. Horiuchi J. Tully Saitoe M. Aging specifically impairs amnesiac-dependent memory in Drosophila.Neuron. 2003; 40: 1003-1011https://doi.org/10.1016/S0896-6273(03)00732-3Abstract Full Text PDF (0) Scholar,3Swenson B.L. Meyer C.F. Bussian T.J. Baker D.J. Senescence disorders central nervous system.Transl. Med. Aging. 2019; 3: 17-25https://doi.org/10.1016/j.tma.2019.01.002Crossref Scholar less is known about changes function during pre-senescent stages adulthood. Adult plasticity likely a key factor social insect age polyethism, where individuals perform different tasks as they divide labor an age-dependent manner.4Beshers S.N. Fewell J.H. Models division insects.Annu. Rev. Entomol. 2001; 46: 413-440https://doi.org/10.1146/annurev.ento.46.1.413Crossref (674) Scholar,5Richardson T.O. Kay Braunschweig R. Journeau O.A. Rüegg McGregor S. Los Rios P.D. Keller L. Ant behavioral maturation mediated by stochastic transition between two fundamental states.Curr. Biol. 2021; 31: 2253-2260.e3https://doi.org/10.1016/j.cub.2020.05.038Abstract (12) Scholar,6Caminer M.A. Libbrecht Majoe Ho D.V. Baumann P. Foitzik Task-specific odorant receptor expression worker antennae indicates that sensory filters regulate ants.Commun. 2023; 6: 1004https://doi.org/10.1038/s42003-023-05273-4Crossref Scholar,7Ferguson S.T. Bakis I. Edwards N.D. Zwiebel L.J. Age task modulate olfactory sensitivity Florida carpenter ant Camponotus floridanus.Insects. 14: 724https://doi.org/10.3390/insects14090724Crossref Scholar,8Page R.E. Erber Levels organization evolution labor.Naturwissenschaften. 2002; 89: 91-106https://doi.org/10.1007/s00114-002-0299-xCrossref Scholar,9Lucas C. Ben-Shahar Y. The foraging gene modulator labour insects.J. Neurogenet. 35: 168-178https://doi.org/10.1080/01677063.2021.1940173Crossref Primarily, workers from nursing to tasks,5Richardson Scholar,10Robinson G.E. Page Huang Z.-Y. Temporal polyethism insects developmental process.Anim. Behav. 1994; 48: 467-469https://doi.org/10.1006/anbe.1994.1260Crossref become more aggressive, readily display alarm behavior11Robinson Modulation pheromone perception honey bee: evidence for based hormonally regulated response thresholds.J. Comp. Physiol. 1987; 613-619https://doi.org/10.1007/BF00611934Crossref Scholar,12Pokorny Sieber L.-M. Hofferberth J.E. Bernadou A. Ruther Age-dependent release ponerine ant.J. Exp. 2020; 223218040https://doi.org/10.1242/jeb.218040Crossref Scholar,13Norman V.C. Hoppé Hughes W.O.H. Old wise but not size: factors affecting threat behaviour nestmate recognition Acromyrmex echinatior leaf-cutting ants.Insectes Soc. 2014; 61: 289-296https://doi.org/10.1007/s00040-014-0355-5Crossref Scholar,14Togni O.C. Giannotti E. Colony defense behavior primitively eusocial wasp, Mischocyttarus cerberus related age.J. Insect Sci. 2010; 10: 136https://doi.org/10.1673/031.010.13601Crossref (10) Scholar,15Giray Genetic variation temporal colony defensiveness bee, Apis mellifera.Behav. Ecol. 2000; 11: 44-55https://doi.org/10.1093/beheco/11.1.44Crossref Scholar,16Norman Butterfield Drijfhout F. Tasman K. Alarm composition activity fungus-growing ants.J. Chem. 43: 225-235https://doi.org/10.1007/s10886-017-0821-4Crossref get older. it unknown how these dynamics are neurally regulated, could partially be generated altered salience behaviorally relevant stimuli.4Beshers Here, we investigated odor coding antennal lobe (AL) with context communication clonal raider (Ooceraea biroi).17Lopes L.E. Frank E.T. Kárpáti Z. Schmitt Kronauer D.J.C. 49: 1-10https://doi.org/10.1007/s10886-023-01407-4Crossref (1) Similar other insects,11Robinson older ants responded rapidly pheromones, chemical signals danger. Using whole-AL calcium imaging,18Hart D.D. Lopes Olivos-Cisneros Lacy K.D. Trible W. Ritger Valdés-Rodríguez Sparse stereotyped encoding implicates core glomerulus behavior.Cell. 186: 3079-3094.e17https://doi.org/10.1016/j.cell.2023.05.025Abstract then mapped representations five general odorants pheromones young old ants. were represented sparsely at all ages. However, responses within individual glomeruli changed age, either increasing or decreasing. Only became sensitized while same time becoming desensitized odorants. Our results suggest heightened occurs via increased glomeruli, illustrating importance modulation age-associated plasticity.

Язык: Английский

Процитировано

7
Regulation of insect cuticular hydrocarbon biosynthesis DOI
Zinan Wang, Ignatius Putra Andika, Henry Chung

и другие.

Current Opinion in Insect Science, Год журнала: 2024, Номер 67, С. 101287 - 101287

Опубликована: Окт. 24, 2024

Язык: Английский

Процитировано

4
Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives DOI
Lauren Fields, Tina C. Dang,

Vu Ngoc Huong Tran

и другие.

ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Neuropeptides are vital signaling molecules involved in neural communication, hormonal regulation, and stress response across diverse taxa. Despite their critical roles, neuropeptide research remains challenging due to low abundance, complex post-translational modifications (PTMs), dynamic expression patterns. Mass spectrometry (MS)-based neuropeptidomics has revolutionized peptide identification quantification, enabling the high-throughput characterization of neuropeptides PTMs. However, complexity vertebrate networks poses significant challenges for functional studies. Invertebrate models, such as Cancer borealis, Drosophila melanogaster, Caenorhabditis elegans, offer simplified circuits, well-characterized systems, experimental tools elucidating roles neuropeptides. These models have revealed conserved families, including allatostatins, RFamides, tachykinin-related peptides, whose homologues regulate analogous physiological functions. Recent advancements MS techniques, ion mobility MALDI imaging, further enhanced spatial temporal resolution analysis, allowing insights into systems. not only expands our understanding functions but also informs translational applications development peptide-based therapeutics. This review highlights utility invertebrate discovery, emphasizing contributions uncovering fundamental biological principles relevance

Язык: Английский

Процитировано

0
Social aphids: emerging model for studying insect sociality DOI
Hui Zhang, Zhixiang Liu, Xiaolei Huang

и другие.

Current Opinion in Insect Science, Год журнала: 2024, Номер 64, С. 101205 - 101205

Опубликована: Июль 17, 2024

Язык: Английский

Процитировано

2
Exploring formation of turanose in honey via stable isotope labelling and high-resolution mass spectrometry analysis DOI
Yuzhe Yuan, Sha Yan, Liming Wu

и другие.

Food Chemistry, Год журнала: 2024, Номер 460, С. 140471 - 140471

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

1
Pheromone representation in the ant antennal lobe changes with age DOI Creative Commons
Taylor Hart,

Lindsey E. Lopes,

Dominic D. Frank

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract While the neural basis of age-related decline has been extensively studied ( 1–3 ), less is known about changes in function during pre-senescent stages adulthood. Adult plasticity likely a key factor social insect age polyethism, where individuals perform different tasks as they and divide labor an age-dependent manner 4–9 ). Primarily, workers transition from nursing to foraging 5 , 10 become more aggressive, readily display alarm behavior 11–16 ) get older. it unknown how these behavioral dynamics are neurally regulated, could partially be generated by altered salience behaviorally relevant stimuli 4 6 7 Here, we investigated odor coding antennal lobe (AL) with context pheromone communication clonal raider ant Ooceraea biroi 17 Similar other insects 11 12 16 older ants responded rapidly pheromones, chemical signals for danger. Using whole-AL calcium imaging 18 then mapped representations five general odorants two pheromones young old ants. Alarm were represented sparsely at all ages. However, responses within individual glomeruli changed age, either increasing or decreasing. Only became sensitized while same time becoming desensitized odorants. Our results suggest that heightened response occurs via increased sensitivity core glomeruli, illustrating importance sensory modulation division age-associated plasticity.

Язык: Английский

Процитировано

0
Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes DOI Creative Commons
Michael Gilbert, Karl M. Glastad,

Maxxum Fioriti

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

ABSTRACT Social insects offer powerful models to investigate the mechanistic foundation of elaborate individual behaviors comprising a cooperative community. Workers leafcutter ant genus Atta provide an extreme example behavioral segregation among many phenotypically distinct worker types. We utilize complex system cephalotes test molecular underpinnings programming and, in particular, extent plasticity reprogramming. identify specific neuropeptides as mediators division labor A. , finding two associated with characteristic leafcutting and brood care. Manipulation via genetic knockdown or by injection these led stark loss gain each behavior transcriptomic shifts predicted direction, that is, towards gene pathways expressed natural caste. also compare transcriptomes those orthologous workers eusocial mammal, naked mole rat H. gaber revealing global similarities between caste-biased expression link roles our studied ants. This work underscores essential function establishing social remarkable

Язык: Английский

Процитировано

0