Bacterial membrane vesicles for vaccine applications

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 185, С. 114294 - 114294

Опубликована: Апрель 15, 2022

Язык: Английский

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Bacteria extracellular vesicle as nanopharmaceuticals for versatile biomedical potential

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Июль 11, 2024

Abstract Bacteria extracellular vesicles (BEVs), characterized as the lipid bilayer membrane-surrounded nanoparticles filled with molecular cargo from parent cells, play fundamental roles in bacteria growth and pathogenesis, well facilitating essential interaction between host systems. Notably, benefiting their unique biological functions, BEVs hold great promise novel nanopharmaceuticals for diverse biomedical potential, attracting significant interest both industry academia. Typically, are evaluated promising drug delivery platforms, on account of intrinsic cell-targeting capability, ease versatile engineering, capability to penetrate physiological barriers. Moreover, attributing considerable immunogenicity, able interact immune system boost immunotherapy nanovaccine against a wide range diseases. Towards these directions, this review, we elucidate nature role activating response better understanding BEV-based nanopharmaceuticals’ development. Additionally, also systematically summarize recent advances achieving target genetic material, therapeutic agents, functional materials. Furthermore, vaccination strategies using carefully covered, illustrating flexible potential combating bacterial infections, viral cancer. Finally, current hurdles further outlook will be provided. Graphical

Язык: Английский

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T Cell-Targeting Nanotherapies for Atherosclerosis

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Cardiovascular diseases remain the leading cause of mortality worldwide. Specifically, atherosclerosis is a primary acute cardiac events. However, current therapies mainly focus on lipid-lowering versus addressing underlying inflammatory response that leads to its development and progression. Nanoparticle-mediated drug delivery offers promising approach for targeting regulating these responses. In atherosclerotic lesions, cascades result in increased T helper (Th) 1 Th17 activity reduced regulatory activation. The regulation cell responses critical preventing imbalance atherosclerosis, making them key therapeutic target nanotherapy achieve precise treatment. By functionalizing nanoparticles with modalities, agents can be delivered specifically immune cells lesions. this Review, we outline role examine nanotherapeutic strategies modulating their differentiation, provide perspectives tailored treatment atherosclerosis.

Язык: Английский

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Drug Nanocrystals: A Delivery Channel for Antiviral Therapies

AAPS PharmSciTech, Год журнала: 2024, Номер 25(3)

Опубликована: Фев. 17, 2024

Язык: Английский

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Development and evaluation of a protease inhibitor antiretroviral drug-loaded carbon nanotube delivery system for enhanced efficacy in HIV treatment

International Journal of Pharmaceutics, Год журнала: 2023, Номер 650, С. 123678 - 123678

Опубликована: Дек. 6, 2023

The primary objective of this study was to enhance the effectiveness protease inhibitor antiretroviral drug by designing a novel delivery system using carboxylated multiwalled carbon nanotubes (COOH-MWCNTs). To achieve this, Fosamprenavir calcium (FPV), prodrug amprenavir known for inhibiting proteolytic cleavage immature virions, selected as drug, and loaded onto COOH-MWCNTs direct loading method. structural specificity drug-loaded MWCNTs, percent entrapment efficiency, in vitro release were rigorously evaluated developed formulation, referred FPV-MWCNT. Fourier transform infrared (FTIR) spectroscopy, Field emission scanning electron microscopy (FE-SEM), Raman atomic force (AFM) techniques employed confirm integrity FPV-MWCNT formulation. results demonstrated remarkable efficiency 79.57 ± 0.4 %, indicating successful FPV COOH-MWCNTs. FE-SEM AFM analyses further confirmed well-dispersed elongated structure without any signs fracture, ensuring stability system. Moreover, particle size analysis revealed an average 290.1 nm, firmly establishing nanoscale range with zeta potential 0.230 mV, signifying system's colloidal stability. In studies conducted methanolic phosphate buffer saline (PBS) at pH 7.4 acetate 5 sustained from Over period 96 h, formulation exhibited cumulative 91.43 2.3 showcasing controlled profile. Furthermore, hemolysis indicated notable reduction toxicity both MWCNT upon conjugation, although increased higher concentrations, suggesting need careful consideration dosage levels. conclusion, findings underscore effective promising drug-conjugated delivering drugs. encapsulation, release, reduced make compelling candidate enhancing therapeutic efficacy drugs treatment HIV. holds great promise future advancements HIV paves way research development field utilizing nanotube-based systems.

Язык: Английский

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Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Фев. 18, 2025

Substance use disorders (SUD) and HIV-associated neurocognitive (HAND) work synergistically as a significant cause of cognitive decline in adults adolescents globally. Current therapies continue to be limited due difficulties crossing the blood-brain barrier (BBB) leading precision effectiveness, neurotoxicity, lack co-treatment options for both HAND SUD. Nanoparticle-based therapeutics have several advantages over conventional including more precise targeting, ability cross BBB, high biocompatibility which decreases toxicity optimizes sustainability. These extend other neurological such Alzheimer's disease (AD) amyotrophic lateral sclerosis (ALS). This review summarizes recent advances nanotechnology application HAND, SUD, co-treatment, well disorders. also highlights potential challenges these face clinical translation long-term safety.

Язык: Английский

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Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

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Nanotechnological Green Synthesis and Its Impact on Plant Science

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 433 - 482

Опубликована: Май 9, 2025

Nanotechnology is a multidisciplinary field that manipulates materials at the nanoscale, typically between 1 and 100 nanometers. It bridges various disciplines, including physics, chemistry, biology, engineering, science, creating with unique properties classical theories cannot predict. central to advancements in energy, medical therapies, environmental solutions, electronics. Nanotechnology's ability create more efficient energy storage systems, such as high-capacity batteries, its potential revolutionize healthcare by enabling personalized medicine further demonstrate vast impact. These innovations offer solutions pressing issues like clean health care, ecological preservation. This chapter focuses on green synthesis methods plant highlighting environmentally friendly techniques for producing nanomaterials. sustainable not only contribute eco-friendly agricultural practices but also promote conservation sustainability of nanotechnology.

Язык: Английский

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Advances in Nanomaterials for Drug Delivery

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2023, Номер unknown, С. 22 - 85

Опубликована: Ноя. 3, 2023

This chapter provides a comprehensive review of recent advances in nanomaterials for drug delivery, focusing on the design and preparation nanocarriers. It also dissects intricate mechanisms underpinning loading release, delves into strategic planning inherent achieving target delivery. further outlines potential applications these treating various diseases, including cancer, infectious neurological disorders. A distinct case study is incorporated chapter, elucidating promising utility electrospun nanofibers delivery paradigms. In its concluding remarks, engages thoughtful discourse about persistent challenges within this rapidly evolving field. forecasts trajectories future exploration innovation captivating domain

Язык: Английский

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Antiviral Potential of Selected N-Methyl-N-phenyl Dithiocarbamate Complexes against Human Immunodeficiency Virus (HIV)

Microbiology Research, Год журнала: 2023, Номер 14(1), С. 355 - 370

Опубликована: Март 8, 2023

Despite the use of highly active antiretroviral therapy approved by United States Food and Drug Administration (FDA) for treatment human immunodeficiency virus (HIV) infection, HIV remains a public health concern due to inability eradicate virus. In this study, N-methyl-N-phenyl dithiocarbamate complexes indium(III), bismuth(III), antimony(III), silver(I), copper(II) were synthesized. The characterized thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR). then evaluated their antiviral effects against HIV-1 subtypes A (Q168), B (QHO.168), C (CAP210 ZM53). results showed that copper(II)-bis (N-methyl-N-phenyl dithiocarbamate) complex had neutralization efficiency 94% CAP210, 54% ZM53, 45% Q168, 63% QHO.168. silver(I)-bis minimal HIV, while indium(III) antimony(III) no activity HIV-1. findings revealed dithiocarbamate), with further improvement, could be explored as an alternative entry inhibitor HIV.

Язык: Английский

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