Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 29, 2024
Hepatocellular
carcinoma
is
the
predominant
histologic
variant
of
hepatic
malignancy
and
has
become
a
major
challenge
to
global
health.
The
increasing
incidence
mortality
hepatocellular
created
an
urgent
need
for
effective
prevention,
diagnosis,
treatment
strategies.
This
despite
impressive
results
multiple
treatments
in
clinic.
However,
unique
tumor
immunosuppressive
microenvironment
increases
difficulty
immune
tolerance.
In
recent
years,
application
nanoparticles
brought
new
hope
patients.
Nano
agents
target
tumor-associated
fibroblasts,
regulatory
T
cells,
myeloid
suppressor
macrophages,
neutrophils,
immature
dendritic
reversed
carcinoma.
addition,
he
purpose
this
review
summarize
advantages
nanotechnology
guiding
surgical
excision,
local
ablation,
TACE,
standard
chemotherapy,
immunotherapy,
nano-vaccines
also
continuously
enriched
liver
cancer.
study
aims
investigate
potential
applications
management
carcinoma,
with
ultimate
goal
enhancing
therapeutic
outcomes
improving
prognosis
patients
affected
by
malignancy.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2091 - 2112
Опубликована: Март 1, 2024
Abstract:
Currently,
cancer
remains
one
of
the
most
significant
threats
to
human
health.
Treatment
cancers
challenging,
despite
implementation
diverse
therapies
in
clinical
practice.
In
recent
years,
research
on
mechanism
ferroptosis
has
presented
novel
perspectives
for
treatment.
Ferroptosis
is
a
regulated
cell
death
process
caused
by
lipid
peroxidation
membrane
unsaturated
fatty
acids
catalyzed
iron
ions.
The
rapid
development
bio-nanotechnology
generated
considerable
interest
exploiting
iron-induced
as
new
therapeutic
target
against
cancer.
This
article
provides
comprehensive
overview
advancements
at
intersection
and
bionanotechnology.
this
respect,
its
relation
are
summarized.
Furthermore,
feasibility
nano-drug
delivery
system
based
treatment
introduced
analyzed.
Secondly,
strategies
inducing
using
nanodrug
technology
discussed,
including
promoting
Fenton
reactions,
inhibiting
glutathione
peroxidase
4,
reducing
low
levels,
Xc
−
.
Additionally,
explores
potential
combined
involving
Finally,
application
prospects
challenges
nanoagents
discussed.
Keywords:
cancers,
ferroptosis,
system,
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 26, 2024
Liver
cancer
is
the
second
leading
cause
of
cancer-related
death
worldwide.
However,
treatment
options,
including
surgical
resection,
transplantation,
and
molecular
drug
therapies,
are
limited
effectiveness.
Recent
studies
have
demonstrated
that
suppressing
ferroptosis
might
be
a
pivotal
signal
for
liver
initiation,
thus
providing
new
way
to
combat
cancer.
Ferroptosis
distinct
form
controlled
cell
differs
from
conventional
routes
like
apoptosis,
necrosis,
pyroptosis.
It
results
intracellular
iron
overload,
which
raises
iron-dependent
reactive
oxygen
species.
This,
in
turn,
leads
accumulation
lipid
peroxides
further
result
oxidative
damage
membranes,
disrupt
normal
functioning,
ultimately
speed
up
phenomenon.
regulation
intricately
linked
cellular
physiological
processes,
encompassing
metabolism,
equilibrium
between
oxygen-free
radical
reactions
peroxidation.
This
review
intends
summarize
natural
compounds
targeting
offer
therapeutic
ideas
Furthermore,
it
serves
as
foundation
identifying
applying
chemical
medicines
chemicals
target
treat
efficiently.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Ferroptosis
is
a
form
of
regulated
cell
death
(RCD)
characterized
by
iron-dependent
lipid
peroxidation.
currently
proposed
as
one
the
most
promising
means
combating
tumor
resistance.
Nevertheless,
problem
ferroptosis
resistance
in
certain
cancer
cells
has
been
identified.
This
review
first,
investigates
mechanisms
induction
cells.
Next,
to
ferroptosis,
well
underlying
discussed.
Recently
discovered
ferroptosis-suppressing
biomarkers
have
described.
The
various
types
nanoparticles
that
can
induce
are
also
Given
ability
combine
multiple
agents,
this
proposes
nanoparticle-based
viable
method
circumventing
suggests
combining
with
other
forms
death,
such
apoptosis,
cuproptosis
and
autophagy.
It
immunotherapy.
Royal Society of Chemistry eBooks,
Год журнала:
2025,
Номер
unknown, С. 30 - 82
Опубликована: Май 7, 2025
Magnetic
nanoparticles
(MNPs)
can
have
their
surfaces
modified
to
customize
functions
and
properties
for
a
range
of
uses.
In
order
achieve
multifunctionality,
this
chapter
thoroughly
analyzes
the
methods
tactics
used
alter
functionalize
MNPs.
Surface
modification
is
examined
in
context
fundamental
elements
MNPs,
such
as
synthesis
techniques
magnetic
behavior.
The
benefits
drawbacks
several
surface
methods,
including
coating,
ligand
exchange,
silanization,
polymer
grafting,
are
explained.
Furthermore,
functionalization
strategies
environmental
biological
applications,
emphasizing
attachment
medicinal
agents,
adsorbents,
imaging
probes,
targeting
ligands.
For
scholars
practitioners
who
intrigued
by
design
optimization
MNPs
various
provides
thorough
reference.
