Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 29, 2024
Hepatocellular
carcinoma
is
the
predominant
histologic
variant
of
hepatic
malignancy
and
has
become
a
major
challenge
to
global
health.
The
increasing
incidence
mortality
hepatocellular
created
an
urgent
need
for
effective
prevention,
diagnosis,
treatment
strategies.
This
despite
impressive
results
multiple
treatments
in
clinic.
However,
unique
tumor
immunosuppressive
microenvironment
increases
difficulty
immune
tolerance.
In
recent
years,
application
nanoparticles
brought
new
hope
patients.
Nano
agents
target
tumor-associated
fibroblasts,
regulatory
T
cells,
myeloid
suppressor
macrophages,
neutrophils,
immature
dendritic
reversed
carcinoma.
addition,
he
purpose
this
review
summarize
advantages
nanotechnology
guiding
surgical
excision,
local
ablation,
TACE,
standard
chemotherapy,
immunotherapy,
nano-vaccines
also
continuously
enriched
liver
cancer.
study
aims
investigate
potential
applications
management
carcinoma,
with
ultimate
goal
enhancing
therapeutic
outcomes
improving
prognosis
patients
affected
by
malignancy.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 11, 2024
Abstract
Colorectal
cancer
(CRC)
is
the
third
most
common,
harmful,
and
universal
second
lethal
type.
This
paper
discusses
therapeutic
potential
of
curcumin,
a
major
curcuminoid
found
in
substructure
plant
Curcuma
longa
(turmeric),
against
CRC.
Curcumin
has
ability
to
disrupt
variety
cellular
signaling
pathways
been
validated
several
preclinical
clinical
studies,
but
suffers
from
low
solubility
bioavailability.
To
address
these
issues,
PLA-HA/Fe
3
O4
magnetic
nanoparticles
were
synthesized
loaded
with
curcumin.
The
average
size
zeta
properties
measured.
drug
encapsulation
efficiency
cumulative
release
curcumin
under
acidic
neutral
pH
values
evaluated,
as
well
cytotoxic
effect
on
HCT116
colorectal
cells.
results
demonstrated
that
have
high
degree
biocompatibility
carry
medications.
cells
200
µg/ml
O
4
/Curcumin
58.63
±
3.7%
percent
cell
viability.
Ultimately,
PLA-HA,
Fe
,
Curcumin's
physicochemical
characteristics
impact
viability
render
them
valuable
instruments
for
precisely
delivering
drugs
-curcumin
well-targeted
delivery
system
upcoming
treatments,
evidenced
by
their
overall
strong
effects
negligible
toxicity
towards
non-cancerous
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Eradication
of
osteomyelitis
caused
by
bacterial
infections
is
still
a
major
challenge.
Microwave
therapy
has
the
inherent
advantage
deep
penetration
in
curing
tissue
infections.
However,
antibacterial
efficiency
sensitizers
limited
weak
energy
microwaves.
Here,
hybrid
heterojunction
system
(Fe
3
O
4
/CuS/Emo)
designed
for
bacterially
infected
osteomyelitis.
As
an
enhanced
microwave
sensitizer,
it
shows
supernormal
response
ability.
Specifically,
Fe
acts
as
matrix
to
mediate
magnetic
loss.
After
CuS
loading,
heterogeneous
interface
forms
induce
significant
interfacial
polarization,
which
increasing
dielectric
On
basis
formed
two
semiconductors,
emodin
innovatively
introduced
modify
it.
This
integration
not
only
accelerates
movement
charge
carriers
but
also
enhances
polarization
loss
due
numerous
functional
groups
present
on
surface.
further
optimizes
thermal
and
catalytic
response.
In
addition,
unique
anti‐inflammatory
properties
confer
ability
regulate
immune
microenvironment.
vivo
studies
reveal
that
modified
programmed
elimination
bacteria
regulation
It
offers
revolutionary
approach
treatment
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 29, 2024
Hepatocellular
carcinoma
is
the
predominant
histologic
variant
of
hepatic
malignancy
and
has
become
a
major
challenge
to
global
health.
The
increasing
incidence
mortality
hepatocellular
created
an
urgent
need
for
effective
prevention,
diagnosis,
treatment
strategies.
This
despite
impressive
results
multiple
treatments
in
clinic.
However,
unique
tumor
immunosuppressive
microenvironment
increases
difficulty
immune
tolerance.
In
recent
years,
application
nanoparticles
brought
new
hope
patients.
Nano
agents
target
tumor-associated
fibroblasts,
regulatory
T
cells,
myeloid
suppressor
macrophages,
neutrophils,
immature
dendritic
reversed
carcinoma.
addition,
he
purpose
this
review
summarize
advantages
nanotechnology
guiding
surgical
excision,
local
ablation,
TACE,
standard
chemotherapy,
immunotherapy,
nano-vaccines
also
continuously
enriched
liver
cancer.
study
aims
investigate
potential
applications
management
carcinoma,
with
ultimate
goal
enhancing
therapeutic
outcomes
improving
prognosis
patients
affected
by
malignancy.
