ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
This
study
aimed
to
develop
trastuzumab
(HCT)-functionalized
albumin
(BSA)-coated,
pyrotinib
(Ptb)-loaded
hollow
mesoporous
selenium
(HSE)
nanoparticles
(HBHSEP)
for
the
targeted
delivery
of
HER2-positive
breast
cancer.
Characterization
pharmaceutical
properties
in
vitro
revealed
that
HBHSEP
was
well
dispersed,
and
particle
size
172
±
3.4
nm.
In
release
experiments
effectively
controlled
Ptb
tumor
microenvironment
(high
glutathione
concentration),
with
a
cumulative
rate
86.5
4.2%
over
48
h.
Cell
uptake
vivo
imaging
confirmed
have
good
tumor-targeting
ability.
The
results
cell
experiments,
such
as
MTT,
flow
cytometry,
immunofluorescence
staining,
antitumor
can
significantly
promote
apoptosis
SK-BR-3
cells
inhibit
their
proliferation.
These
findings
strongly
show
may
be
an
effective
treatment
Molecules,
Год журнала:
2024,
Номер
29(23), С. 5713 - 5713
Опубликована: Дек. 3, 2024
Nanotechnology
has
significantly
advanced
various
fields,
including
therapeutic
delivery,
through
the
use
of
nanomaterials
as
drug
carriers.
The
biocompatibility
ordered
porous
silica
materials
makes
them
promising
candidates
for
delivery
systems,
particularly
in
treatment
cancer
and
other
diseases.
This
review
summarizes
microporous
zeolites
mesoporous
focusing
on
their
physicochemical
properties
applications
Special
emphasis
is
placed
strategies
encapsulation
functionalization,
highlighting
role
enhancing
loading
enabling
targeted
delivery.
In
conclusion,
while
hold
great
potential
certain
challenges
remain.
Biotechnology Journal,
Год журнала:
2024,
Номер
19(10)
Опубликована: Окт. 1, 2024
ABSTRACT
How
to
use
and
deliver
drugs
diseased
damaged
areas
has
been
one
of
the
main
concerns
pharmacologists
doctors
for
a
long
time.
With
efforts
researchers,
advancement
technology,
involvement
engineering
in
health
field,
diverse
promising
approaches
have
studied
used
achieve
this
goal.
A
better
understanding
biomaterials
ability
production
equipment
led
researchers
offer
new
drug
delivery
systems
world.
In
recent
decades,
responsive
polymers
(exclusively
temperature
pH)
supramolecular
received
much
attention
due
their
unique
capabilities.
Although
field
research
still
needs
be
scrutinized
more,
recognition,
examination,
as
is
start
future.
This
review
study,
focusing
on
temperature‐responsive
application
systems,
deals
with
structure,
properties,
role
noninvasive
effective
medicinal
agents.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
This
study
aimed
to
develop
trastuzumab
(HCT)-functionalized
albumin
(BSA)-coated,
pyrotinib
(Ptb)-loaded
hollow
mesoporous
selenium
(HSE)
nanoparticles
(HBHSEP)
for
the
targeted
delivery
of
HER2-positive
breast
cancer.
Characterization
pharmaceutical
properties
in
vitro
revealed
that
HBHSEP
was
well
dispersed,
and
particle
size
172
±
3.4
nm.
In
release
experiments
effectively
controlled
Ptb
tumor
microenvironment
(high
glutathione
concentration),
with
a
cumulative
rate
86.5
4.2%
over
48
h.
Cell
uptake
vivo
imaging
confirmed
have
good
tumor-targeting
ability.
The
results
cell
experiments,
such
as
MTT,
flow
cytometry,
immunofluorescence
staining,
antitumor
can
significantly
promote
apoptosis
SK-BR-3
cells
inhibit
their
proliferation.
These
findings
strongly
show
may
be
an
effective
treatment
