Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer's disease based on Cu2+ chelation and photothermal therapy
Journal of Controlled Release,
Год журнала:
2024,
Номер
375, С. 269 - 284
Опубликована: Сен. 13, 2024
Язык: Английский
Biological Waste-Derived Carbon Dots and Their Applications
Nanostructure science and technology,
Год журнала:
2025,
Номер
unknown, С. 107 - 128
Опубликована: Янв. 1, 2025
Язык: Английский
CeO2 In Situ Growth on Red Blood Cell Membranes: CQD Coating and Multipathway Alzheimer’s Disease Therapy under NIR
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(28), С. 35898 - 35911
Опубликована: Июль 2, 2024
Alzheimer's
disease
(AD)
has
a
complex
etiology
and
diverse
pathological
processes.
The
therapeutic
effect
of
single-target
drugs
is
limited,
so
simultaneous
intervention
multiple
targets
gradually
becoming
new
research
trend.
Critical
stages
in
AD
progression
involve
amyloid-β
(Aβ)
self-aggregation,
metal-ion-triggered
fibril
formation,
elevated
reactive
oxygen
species
(ROS).
Herein,
red
blood
cell
membranes
(RBC)
are
used
as
templates
for
the
situ
growth
cerium
oxide
(CeO2)
nanocrystals.
Then,
carbon
quantum
dots
(CQDs)
encapsulated
to
form
nanocomposites
(CQD-Ce-RBC).
This
strategy
combined
with
photothermal
therapy
(PTT)
therapy.
application
RBC
enhances
materials'
biocompatibility
improves
immune
evasion.
RBC-grown
CeO2,
first
field
AD,
demonstrates
outstanding
antioxidant
properties.
CQD
acts
chelating
agent
copper
ions,
which
prevents
aggregation
Aβ.
In
addition,
thermal
induced
by
near-infrared
laser-induced
can
break
down
Aβ
fibers
improve
permeability
blood-brain
barrier.
vivo
experiments
on
APP/PS1
mice
demonstrate
that
CQD-Ce-RBC
PTT
effectively
clears
cerebral
amyloid
deposits
significantly
learning
cognitive
abilities,
thereby
retarding
progression.
innovative
multipathway
approach
under
light-induced
conditions
holds
promise
treatment.
Язык: Английский
Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer’s disease mice with triple therapy
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
670, С. 125112 - 125112
Опубликована: Дек. 27, 2024
Язык: Английский
Sustainable Release Selenium Laden with SiO2 Restoring Peripheral Nerve Injury via Modulating PI3K/AKT Pathway Signaling Pathway
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7851 - 7870
Опубликована: Авг. 1, 2024
Inhibiting
ROS
overproduction
is
considered
a
very
effective
strategy
for
the
treatment
of
peripheral
nerve
injuries,
and
Se
has
remarkable
antioxidant
effect;
however,
since
difference
between
concentration
toxic
dose
not
large,
we
synthesized
nanomaterial
that
can
release
slowly
so
it
be
used
more
effectively.
Язык: Английский
Nanocrystals: a new herald for the management of Alzheimer’s disease
Journal of Dispersion Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 1 - 14
Опубликована: Окт. 6, 2024
Alzheimer's
disease
(AD)
impairs
mental
development
and
interrupts
neurocognitive
functions
that
escalate
with
time
leading
to
death.
With
continuous
evolution
in
lifestyle
progression
of
age,
the
prevalence
AD
is
progressively
rising,
a
significant
economic
burden.
Thus,
effective
therapeutic
approaches
are
indeed
necessary
address
this
growing
concern.
Current
treatment
regimens
primarily
help
relieve
symptoms,
nevertheless,
nanotechnology-based
nerve
damage
can
be
regressed
along
reduction
inflammation
improved
brain
delivery.
Researchers
healthcare
professionals
working
diligently
develop
innovative
treatments
interventions
improve
quality
life
for
individuals
affected
by
AD.
This
review
paper
aims
provide
comprehensive
insights
on
pathogenesis,
FDA-approved
treatment,
recent
advancements
drug
therapy,
formulation
an
update
drugs
different
clinical
phases.
The
specifically
highlights
nanocrystals-based
formulations
their
ability
minimize
side
effects,
bioavailability,
pharmacodynamics
pharmacokinetics.
current
also
prospects
role
NCs
enabling
delivery
across
BBB
it
dives
deep
understand
its
potential
carve
out
directions
niche
area
treating
Язык: Английский
Advancing Alzheimer’s Disease Modelling by Developing a Refined Biomimetic Brain Microenvironment for Facilitating High-Throughput Screening of Pharmacological Treatment Strategies
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 241 - 241
Опубликована: Дек. 30, 2024
Alzheimer’s
disease
(AD)
poses
a
significant
worldwide
health
challenge,
requiring
novel
approaches
for
improved
models
and
treatment
development.
This
comprehensive
review
emphasises
the
systematic
development
improvement
of
biomimetic
brain
environment
to
address
shortcomings
existing
AD
enhance
efficiency
screening
potential
drug
treatments.
We
identify
drawbacks
in
traditional
emphasise
necessity
more
physiologically
accurate
systems
through
an
in-depth
analysis
current
literature.
aims
study
advanced
model
that
accurately
replicates
key
pathophysiological
aspects
using
cutting-edge
biomaterials
microenvironment
design.
Incorporating
biomolecular
elements
like
Tau
proteins
beta-amyloid
(Aβ)
plaques
improve
accuracy
illustrating
mechanisms.
The
expected
results
involve
creating
solid
foundation
high-throughput
with
enhanced
scalability,
translational
significance,
possibility
speeding
up
discovery.
Thus,
this
fills
gaps
modelling
shows
precise
efficient
treatments
AD.
Язык: Английский