Core-Shell Hybrid Liposomes: Transforming Imaging Diagnostics and Therapeutic Strategies

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114597 - 114597

Опубликована: Фев. 1, 2025

Язык: Английский

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Artificial cells and Biomimicry cells: A Rising Star in the Fight Against Cancer

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101723 - 101723

Опубликована: Апрель 1, 2025

Biomimetic Artificial Cells (ACs) are engineered systems that mimic the properties and functions of natural cells, offering significant potential for biomedical applications. The performance applicability these synthetic constructs depend on choice materials fabrication methods. Our review delves into materials, techniques, diverse applications ACs, emphasizing their transformative impact field cancer therapy as smart vehicles drug delivery, immune system stimulation, cell targeting to minimize off-target effects maximizing therapeutic efficacy well in vitro models research. By providing a comprehensive overview, we aim elucidate how cells can move forward, innovative solutions longstanding challenges treatment opening new frontiers less toxic options.

Язык: Английский

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Advancements in Ischemic Stroke Management: Transition from Traditional to Nanotechnological Approaches

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106318 - 106318

Опубликована: Окт. 1, 2024

Язык: Английский

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Carcinoma–Astrocyte Gap Junction Interruption by a Dual-Targeted Biomimetic Liposomal System to Attenuate Chemoresistance and Treat Brain Metastasis

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Brain metastasis contributes substantially to the morbidity and mortality of various malignancies is characterized by high chemoresistance. Intracellular communication between carcinoma cells astrocytes through gap junctions, which are assembled mainly connexin 43 protein, has been shown play a vital role in this process. However, effectively blocking junctions two cell types remains extremely challenging because insufficient drug delivery target site. Herein, we designed blocker-carbenoxolone (CBX)-loaded biomimetic liposomal system with artificial liposomes fused brain metastatic reactive astrocyte membranes (LAsomes) block attenuate LAsomes penetrated blood–brain barrier via semaphorin 4D (SEMA 4D)─Plexin B1 interactions actively migrated their source homotypic recognition. Consequently, inhibited material transfer Ca2+ flow from thereby markedly increasing sensitivity tumor chemotherapy. These results reveal that closing may be promising therapeutic strategy for intractable metastasis.

Язык: Английский

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Multifunctional biomimetic nanosystem for retinoblastoma treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 156017 - 156017

Опубликована: Окт. 5, 2024

Язык: Английский

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