Recent advances in polymeric nanoparticles for the treatment of hepatic diseases
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Язык: Английский
Cancer cell membrane-camouflaged paclitaxel/PLGA nanoparticles for targeted therapy against lung cancer
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117102 - 117102
Опубликована: Июль 10, 2024
Paclitaxel
(PTX)
is
a
first-line
drug
for
the
treatment
of
lung
cancer,
but
its
targeting
and
therapeutic
effect
are
unsatisfactory.
Herein,
cancer
cell
(A549)
membrane
biomimetic
PTX-loaded
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(AM@PTX-NPs)
were
constructed
to
eliminate
shortcomings
PTX.
The
AM@PTX-NPs
successfully
prepared
with
high
loading
efficiency
(10.90±0.06
%).
Moreover,
transmission
electron
microscopy,
SDS-PAGE,
western
blotting
proved
that
spherical
camouflaged
by
A549
membrane.
Both
in
vitro
vivo
assays
revealed
displayed
outstanding
capacity
due
modification.
cytotoxicity
experiment
showed
developed
formulation
was
able
effectively
reduce
proliferation
cells.
exhibited
significant
tumor
growth
inhibition
rate
(73.00
%)
good
safety
tumor-bearing
mice,
which
higher
than
PTX-NPs
without
coating
(37.39
Overall,
bioinspired
vector
could
provide
novel
platform
PTX
delivery
demonstrated
promising
strategy
targeted
treatment.
Язык: Английский
Curcumin and Its Derivatives in Hepatology: Therapeutic Potential and Advances in Nanoparticle Formulations
Cancers,
Год журнала:
2025,
Номер
17(3), С. 484 - 484
Опубликована: Фев. 1, 2025
Curcumin,
a
plant-derived
polyphenol,
shows
promise
in
hepatology
for
treating
both
malignant
and
non-malignant
liver
diseases
subset
of
extrahepatic
cancers.
Curcumin
has
hepatoprotective,
anti-inflammatory,
antifibrotic,
antiproliferative
properties,
as
is
evident
preclinical
clinical
studies.
This
highlights
its
potential
an
adjunct
to
established
cancer
therapies,
especially
the
context
hepatocellular
carcinoma
secondary
malignancies.
also
demonstrates
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
owing
antifibrotic
lipid-lowering
effects.
However,
use
limited,
relating
poor
bioavailability
rapid
metabolism.
Nanotechnology,
including
liposomal
polymeric
carriers,
alongside
synthetic
curcumin
derivatives,
offers
strategies
enhance
pharmacokinetic
properties.
We
propose
revisit
nanoparticle
preparations
chronic
summarize
current
evidence
this
review
article.
Язык: Английский
Engineered nanoparticles for imaging and targeted drug delivery in hepatocellular carcinoma
Experimental Hematology and Oncology,
Год журнала:
2025,
Номер
14(1)
Опубликована: Апрель 30, 2025
Liver
cancer,
notably
hepatocellular
carcinoma
(HCC),
poses
a
significant
global
health
burden
due
to
its
high
fatality
rates.
Conventional
antitumor
medications
face
challenges,
including
poor
targeting,
toxicity,
and
drug
resistance,
leading
suboptimal
clinical
outcomes.
This
review
focused
on
nanoparticle
use
in
diagnosing
delivering
medication
for
HCC,
aiming
advance
the
development
of
nanomedicines
improved
treatment
As
an
emerging
frontier
science
technology,
nanotechnology
has
shown
great
potential,
especially
precision
medicine
personalized
treatment.
The
success
nanosystems
is
attributable
their
smaller
size,
biocompatibility,
selective
tumor
accumulation,
lower
toxicity.
Nanoparticles,
as
central
part
innovation,
have
emerged
field
medical
diagnostics
therapeutics
overcome
various
limitations
conventional
chemotherapy,
thus
offering
promising
applications
selectivity,
earlier
more
precise
diagnosis
cancers,
treatment,
overcoming
resistance.
Nanoparticles
play
crucial
role
delivery
imaging
with
body
acting
system
target
deliver
drugs
or
diagnostic
reagents
specific
organs
tissues,
helping
accurately
diagnose
therapies
while
minimizing
damage
healthy
tissues.
They
protect
from
early
degradation
increase
biological
half-life.
Язык: Английский
Bio-Inspired Nanodelivery Platform: Platelet Membrane-Cloaked Genistein Nanosystem for Targeted Lung Cancer Therapy
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10455 - 10478
Опубликована: Окт. 1, 2024
Genistein
(Gen),
a
natural
polyphenolic
compound,
has
emerged
as
promising
candidate
for
lung
cancer
treatment.
However,
the
potential
clinical
application
of
Gen
is
limited
due
to
its
poor
solubility,
low
bioavailability,
and
toxic
side
effects.
To
address
these
challenges,
biomimetic
delivery
platform
with
cell
membranes
derived
from
cells
carrier
material
was
constructed.
This
innovative
approach
aims
facilitate
targeted
drug
solve
problem
biocompatibility
synthetic
materials.
Язык: Английский