Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, biocompatibility. However, inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts clinical adoption. Herein, strontium (Sr) incorporated onto the surface of PEEK using mussel-inspired polydopamine coating improve activity. X-ray photoelectron spectroscopy ion release assay results confirm that different concentrations Sr are substrate surfaces. The strontium-modified samples show a stable 35 days detection. Better MC3T3-E1 pre-osteoblasts adhesion, spreading, proliferation can be observed groups, demonstrates with improved compatibility. boosted activity has been demonstrated by better performed ALP extracellular matrix mineralization, collagen secretion, remarkable up-regulation ALP, OCN, OPN, Runx2, Col-I, BSP, OSX pre-osteoblasts. Additionally, exhibit dose-dependent enhancement osteoblasts compatibility PEEK-Sr10 group shows best. These findings indicate strontium-decorated promising application implants.

Язык: Английский

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Regulation of the diabetic immune microenvironment by metformin-loaded strontium-doped mesoporous bioactive glass facilitates bone regeneration

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Strontium-doped mesoporous bioactive glass loading metformin (MET/SrMBG) can be utilized to regulate chronic inflammation in the diabetic microenvironment, ultimately facilitating bone repair.

Язык: Английский

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Synergetic improvement of osteogenic and antibacterial activities of TiO2 nanotubes on titanium alloys by combining Sr2+ ions with CO molecules

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163996 - 163996

Опубликована: Май 1, 2025

Язык: Английский

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Bioactive Glass and Melittin Thin Films Deposited by MAPLE for Titanium Implant Functionalization

Materials, Год журнала: 2025, Номер 18(10), С. 2410 - 2410

Опубликована: Май 21, 2025

The development of bioactive coatings for metallic implants is essential to enhance osseointegration and improve implant longevity. In this study, composite thin films based on glass melittin were synthesized using the matrix-assisted pulsed laser evaporation technique deposited onto titanium substrates. characterized physicochemical analysis methods, including scanning electron microscopy, atomic force contact angle measurements, Fourier transform infrared spectroscopy, energy-dispersive X-ray electrochemical impedance spectroscopy. Simulated body fluid immersion tests also conducted assess bioactivity over time. Scanning microscopy revealed dense, irregular surface textures with nanoscale features an average roughness ~120 nm, favorable cell adhesion. Contact measurements showed a significant shift from hydrophobic (~95° bare titanium) moderately hydrophilic (~62° bioglass coating) surfaces, indicating improved biocompatibility. Electrochemical spectroscopy demonstrated enhanced corrosion resistance in simulated fluid, coating exhibiting ~45% decrease magnitude after 12 h immersion, compared only 4% titanium. analyses confirmed progressive formation carbonated apatite layer 7 days exposure, suggesting high osteoconductive potential. combined effects film structure offer promising applications orthopedic dental implants, enhancing both biological performance structural integrity.

Язык: Английский

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Alternative to surface sulfonation: Biofunctionalizing PEEK surfaces via 3D porous coatings using the nonsolvent-induced phase separation approach

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164025 - 164025

Опубликована: Май 1, 2025

Язык: Английский

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