A Polysaccharide Metal Phenolic Network Nanocomposite for Theranostic Applications in Inflammatory Bowel Disease DOI

Jianlun Hu,

Xiaofeng Wang, Qi Sun

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Nanotechnology has significantly facilitated the diagnosis and therapy of inflammatory bowel disease (IBD). To obtain better therapeutic efficacy, a nanoplatform built from polysaccharides metal‐phenolic networks (MPN) is developed here to enhance retention in damaged intestinal region modulate systemic immunological status IBD models. Polysaccharides tragacanth gum (GUM) are coordinated with iron further interact shikonin (Shik) nanocomposite named Shik‐Fe@GUM. Shik‐Fe@GUM demonstrates strong persistent accumulation inflamed region, which validated clinical specimens patients, cocultured cellular models, living animals. served as scavenger for reactive oxygen or nitrogen species tissues cells, alleviated local by cytokine downregulation. In addition, restored functions colonic barriers mitigate activity index. The working mechanisms also explored genetic sequencing results revealed that imposed its treatment effect attenuating major pathways. particular, can IL‐17RA relevant cell signaling reduce recruitment T h 17 cells (T helper 17). This polysaccharide‐metal‐functional molecule hybrid strategy be broadly applicable other drugs their index patients.

Язык: Английский

Recent advances in tannic acid-based gels: Design, properties, and applications DOI
Zuwu Tang,

Ilnaz Fargul Chowdhury,

Jinbei Yang

и другие.

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 339, С. 103425 - 103425

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

3

Rapid synthesis of CuTA/Cur@ZIF-8 multifunctional drug delivery system towards cancer treatment DOI
Luan Minh Nguyen,

Giao Thuy-Quynh Vu,

Thi‐Kim‐Chi Huynh

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136321 - 136321

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Exploring Nucleic Acid Nanozymes: A New Frontier in Biosensor Development DOI Creative Commons

Keren Chen,

Zaihui Du,

Yangzi Zhang

и другие.

Biosensors, Год журнала: 2025, Номер 15(3), С. 142 - 142

Опубликована: Фев. 24, 2025

With the growing interest in nucleic acids and nanozymes, acid nanozymes (NANs) have emerged as a promising alternative to traditional enzyme catalysts, combining advantages of nanomaterials, are widely applied field biosensing. This review provides comprehensive overview recent studies on NAN-based biosensors. It classifies NANs based six distinct enzymatic activities: peroxidase-like, oxidase-like, catalase-like, superoxide dismutase-like, laccase-like, glucose oxidase-like. emphasizes how catalytic activity is significantly influenced by properties explores regulatory mechanisms governing NANs. Additionally, it systematically reviews important research progress colorimetric, fluorescent, electrochemical, SERS, chemiluminescent sensors, offering insights into development NAN biosensor applications.

Язык: Английский

Процитировано

1

Advancing Diabetic Wound Care: The Role of Copper-containing Hydrogels DOI Creative Commons

Mohammad Ebrahim Astaneh,

Narges Fereydouni

Heliyon, Год журнала: 2024, Номер 10(20), С. e38481 - e38481

Опубликована: Сен. 26, 2024

Язык: Английский

Процитировано

6

Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications DOI Creative Commons
Oana Cioancă, Ionuţ-Iulian Lungu, Denisa Batîr-Marin

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 194 - 194

Опубликована: Фев. 4, 2025

Background: The skin represents the first barrier of defense, and its integrity is crucial for overall health. Skin wounds present a considerable risk seeing how their progression rapid sometimes they are caused by comorbidities like diabetes venous diseases. Nutraceutical combinations ones between polyphenols metal ions applications thanks to increased bioavailability ability modulate intrinsic molecular pathways. Methods: research findings presented in this paper based on systematic review current literature with an emphasis nanotechnology regenerative medicine strategies that incorporate metallic nanoparticles (NPs). key studies which described action mechanisms, efficacy, safety these hybrid formulations were reviewed. Results: Nanocomposites polyphenol promote healing activating signaling pathways such as PI3K/Akt ERK1/2, turn improve fibroblast migration proliferation. Nanoparticles silver copper have antibacterial, angiogenesis-promoting, inflammation-modulating capabilities. With induce apoptosis restrict cell growth, composites potential cure malignancies addition facilitating wound healing. Conclusions: metals provide hope treatment cancer chronic wounds. Their antimicrobial capabilities, capacity inflammatory responses, enhancement activity all point medicinal potential. Furthermore, decrease inflammation associated tumors while simultaneously inducing death cells. Clarifying guaranteeing stability, enhancing effective delivery techniques clinical usage should be focus future studies.

Язык: Английский

Процитировано

0

Copper in melanoma: at the crossroad of protumorigenic and anticancer roles DOI Creative Commons

Natalia Chrzan,

Mariusz L. Hartman

Redox Biology, Год журнала: 2025, Номер 81, С. 103552 - 103552

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

0

Exploring the antibiotic potential of copper carbonate nanoparticles, wound healing, and glucose-lowering effects in diabetic albino mice DOI
Muhammad Waseem Aslam,

Sabeen Sabri,

Ali Umar

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151527 - 151527

Опубликована: Фев. 22, 2025

Язык: Английский

Процитировано

0

Corn Silk-Derived Bioactives as Polyphenol Oxidase Inhibitors: Mechanisms and Applications in Food Preservation DOI

Flores-Sauceda Marcela,

Elsa Daniela Othón-Díaz,

Jorge O. Fimbres-García

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106411 - 106411

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Fabrication and characterization of a colorimetric sensor using EDTA-capped copper oxide nanoparticles for phenolic compound detection DOI Creative Commons
Mohammad Saeid Abbasi, Umaima Saleem Memon, Abdul Wahab Memon

и другие.

Mehran University Research Journal of Engineering and Technology, Год журнала: 2025, Номер 44(2), С. 62 - 70

Опубликована: Апрель 9, 2025

The catalytic and antibacterial properties of metal oxide nanoparticles make them suitable contributors to the formation new production facilities at low cost. In this study, we prepared copper (CuONPs) via an environmentally friendly cost-effective synthesis route. We used Ethylene diamine tetra acetic acid (EDTA) as a capping reducing agent synthesize nanoparticles. Textural characterization CuONPs was studied using advanced techniques, for example, Fourier transmission infrared (FTIR) study functional transition (EDTA reduction), scanning electron microscopy (SEM) analyze shape CuONPs, X-ray diffraction patterns examine crystalline nature particles. were then perform amperometry measurements monitor trace amounts isoflavone (IFs) in various industrial wastewater phytoestrogen drugs from patients water samples. results show that developed sensor has excellent analytical parameters such high sensitivity sensor, uniformly distributed, controlled size, stability neutral pH, good selectivity (no interference), method preparing fabricating mid-frequency sensors. research oxidation state particle size played vital role enhanced process. EDTA-CuONPs with smallest biocompatibility, surface reactivity, uniform distribution assembled morphology, activity ideal applications including environment monitoring, catalysis, biosensing.

Язык: Английский

Процитировано

0

A Polysaccharide Metal Phenolic Network Nanocomposite for Theranostic Applications in Inflammatory Bowel Disease DOI

Jianlun Hu,

Xiaofeng Wang, Qi Sun

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Nanotechnology has significantly facilitated the diagnosis and therapy of inflammatory bowel disease (IBD). To obtain better therapeutic efficacy, a nanoplatform built from polysaccharides metal‐phenolic networks (MPN) is developed here to enhance retention in damaged intestinal region modulate systemic immunological status IBD models. Polysaccharides tragacanth gum (GUM) are coordinated with iron further interact shikonin (Shik) nanocomposite named Shik‐Fe@GUM. Shik‐Fe@GUM demonstrates strong persistent accumulation inflamed region, which validated clinical specimens patients, cocultured cellular models, living animals. served as scavenger for reactive oxygen or nitrogen species tissues cells, alleviated local by cytokine downregulation. In addition, restored functions colonic barriers mitigate activity index. The working mechanisms also explored genetic sequencing results revealed that imposed its treatment effect attenuating major pathways. particular, can IL‐17RA relevant cell signaling reduce recruitment T h 17 cells (T helper 17). This polysaccharide‐metal‐functional molecule hybrid strategy be broadly applicable other drugs their index patients.

Язык: Английский

Процитировано

1