Nanotechnology, Год журнала: 2024, Номер 36(4), С. 045101 - 045101

Опубликована: Окт. 30, 2024

Abstract The tumor microenvironment (TME) is characterized by low pH, hypoxia, and overexpression of glutathione (GSH). Owing to the complexity pathogenesis heterogeneity TME, achieving satisfactory efficacy with a single treatment method difficult, which significantly impedes treatment. In this study, composite nanoparticles calcium-copper/alginate-hyaluronic acid (HA) (CaO 2 -CuO @SA/HA NC) pH GSH responsiveness were prepared for first time through one-step synthesis using HA as targeting ligand. Nanoparticles loaded H O can enhance chemodynamic therapy effects. Simultaneously, Cu 2+ generate oxygen in TME alleviate hypoxia tissue. undergo Fenton reaction produce cytotoxic hydroxyl radicals Ca ions, localization clearance cells. Additionally, sodium alginate (SA) utilized improve biocompatibility nanoparticles. Fourier transform infrared, x-ray diffraction, dynamic light scattering, SEM, transmission electron microscope, other analytical methods used investigate their physical chemical properties. results indicate that CaO NC had particle size 220 nm, narrow distribution, uniform morphology. hydrogen peroxide self-supplied nanodrug delivery system exhibited excellent pH-responsive release performance glutathione-responsive •OH ability while also reducing level reactive oxide species quenching. vitro cell experiments, no obvious side effects on normal tissues observed; however, inhibition rate malignant tumors HepG2 DU145 exceeded 50%. preparation nanoparticles, achieve both chemokinetic ion interference therapy, has demonstrated significant potential clinical applications cancer therapy.

Язык: Английский