Fabrication of pH‐sensitive bacterial cellulose/carboxymethyl cellulose hybrid hydrogel beads in agitated culture for oral drug delivery

The Canadian Journal of Chemical Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Abstract Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl was introduced to the agitated culture of Gluconacetobacter xylinus produce pH‐responsive BC hydrogel beads. It shown by x‐ray diffraction (XRD) analysis that adding carboxymethyl increased crystallinity Scanning electron microscopy exhibited 3‐D porous structure microfibrils and reverse effect on hydrogels' porosity. The hydrogels were loaded ibuprofen sodium salt (IbuNa), their release swelling studies conducted simulated gastric intestinal fluids. observed increasing amount medium, pH responsivity beads increased. Thus, this study shows potential BC/CMC system as an oral drug delivery system.

Язык: Английский

Development and Evaluation of Tween-80 Modified Breviscapine Nanocrystals for Enhanced Oral Absorption

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106819 - 106819

Опубликована: Март 1, 2025

Язык: Английский