Results in Chemistry,
Год журнала:
2023,
Номер
6, С. 101036 - 101036
Опубликована: Июль 20, 2023
The
complex
di(p-methylbenzyl)
(dibromo)(4,7-diphenyl-1,10-phenanthroline)
tin
(IV)
(B1)
was
synthesized
and
characterized.
For
the
theoretical
investigation,
we
used
DFT.
With
help
of
Multiwfn
software
package,
topological
analysis
RDG
were
calculated.
A
very
low
energy
gap
(2.3
eV)
observed
in
HOMO-LUMO
analysis.
Nucleophilic
electrophilic
attacking
sites
are
confirmed
using
MEP
study.
In
a
single
crystal,
octahedral
shape
monoclinic
space
group.
intramolecular
hydrogen
formed
through
C—H—Br.
atom
is
uniform
shape,
which
can
be
seen
XRD
B1.
Vero
Hela
cell
lines
for
anticancer
cytotoxic
activities.
Our
shows
better
activity
against
when
compared
to
cisplatin.
Heliyon,
Год журнала:
2023,
Номер
9(9), С. e20090 - e20090
Опубликована: Сен. 1, 2023
Until
now,
many
methods
have
been
proposed
to
treat
cancer,
such
as
radiation
therapy
and
drug
therapy,
but
none
of
them
caused
a
complete
cure
for
cancer.
Heavy
metal
complexes
cisplatin
are
among
the
compounds
used
drugs
in
chemotherapy
against
cancer
cells.
These
cause
cell
death
anti-cancer
properties,
they
side
effects.
The
biochemical
mechanism
is
related
its
interaction
with
DNA
through
covalent
binding.
To
reduce
toxicity
metallodrugs,
new
can
be
designed
containing
S,
S-
bidentate
ligands
diethyldithiocarbamate.
Moreover,
probably
interact
proteins,
HSA,
before
passing
cancerous
membrane
target.
So,
function
proteins
their
stabilities
expected
change.
In
this
research,
mode
binding
[Pt
(bpy)
(amyl.dtc)]NO3
complex
BSA
was
evaluated
by
various
thermodynamic
methods.
Negative
enthalpy
entropy
changes
amounts
show
that
connection
between
Platinum
compound
occurs
via
van
Der
Waals
type
hydrogen
bond.
negative
Gibbs
free
energy
change
obtained
isothermal
titration,
which
showed
proceeds
spontaneously.
emission
titration
data
protein
fluorescence
quenching
platinum
agent
static.
Binding,
constants,
site
number
were
Stern-Volmer
equation,
only
one
determined
interaction.
A
Scatchard
plot
positive
slope
shows
Pt
agent-BSA
formation
proceeding
positively
cooperative.
kinetic
study
displayed
absorption
monitoring
followed
second-order
model.
Finally,
molecular
docking
simulation
position
on
placed
I
under
region
II.
