Exploring Heterogeneity: A Dive into Pre-Clinical Models of Cancer Cachexia
AJP Cell Physiology,
Год журнала:
2024,
Номер
327(2), С. C310 - C328
Опубликована: Июнь 10, 2024
Cancer
cachexia
(CC)
is
a
multifactorial
and
complex
syndrome
experienced
by
up
to
80%
of
patients
with
cancer
implicated
in
∼40%
cancer-related
deaths.
Given
its
significant
impact
on
patients’
quality
life
prognosis,
there
has
been
growing
emphasis
elucidating
the
underlying
mechanisms
CC
using
preclinical
models.
However,
appear
differ
across
several
variables
including
tumor
type
model
biologic
such
as
sex.
These
differences
may
be
exacerbated
variance
experimental
approaches
data
reporting.
This
review
examines
literature
spanning
from
2011
March
2024,
focusing
common
models
CC,
Lewis
Lung
Carcinoma,
pancreatic
KPC,
colorectal
colon-26
Apc
min/+
Our
analysis
reveals
considerable
heterogeneity
phenotypic
outcomes,
investigated
within
each
model,
particular
attention
sex
that
through
methodological
differences.
Although
searching
for
unified
critical,
we
posit
effective
treatment
are
likely
leverage
presented
pertinent
biological
direct
specific
interventions.
In
exploring
this
heterogeneity,
it
becomes
critical
consider
reporting
best
inform
further
research.
Язык: Английский
Transcriptional Analysis of Cancer Cachexia: Conserved and Unique Features Across Pre-Clinical Models and Biological Sex
AJP Cell Physiology,
Год журнала:
2024,
Номер
327(6), С. C1514 - C1531
Опубликована: Окт. 28, 2024
This
study
is
among
the
first
to
integrate
and
compare
skeletal
muscle
transcriptional
landscape
across
multiple
preclinical
models
biological
sexes.
We
highlight
that
1)
early
CC
changes
are
two-thirds
conserved
at
late
stages,
2)
DEGs
largely
model
sex
specific,
3)
factors
including
CLOCK
ARNTL/BMAL1,
which
influence
gene
expression,
might
represent
a
global
therapeutic
target
with
chance
of
efficacy
various
cancer
types.
Язык: Английский