Exploring neuroblastoma’s cellular microenvironment: A novel approach using cellular automata to model Celyvir treatment

Computers in Biology and Medicine, Год журнала: 2025, Номер 188, С. 109782 - 109782

Опубликована: Фев. 12, 2025

Язык: Английский

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Proneural-mesenchymal antagonism dominates the patterns of phenotypic heterogeneity in glioblastoma

iScience, Год журнала: 2024, Номер 27(3), С. 109184 - 109184

Опубликована: Фев. 13, 2024

The aggressive nature of glioblastoma (GBM) - one the deadliest forms brain tumors is majorly attributed to underlying phenotypic heterogeneity. Early attempts classify this heterogeneity at a transcriptomic level in TCGA GBM cohort proposed existence four distinct molecular subtypes: Proneural, Neural, Classical, and Mesenchymal. Further, single-cell RNA sequencing (scRNA-seq) analysis primary also reported similar subtypes mimicking neurodevelopmental lineages. However, it remains unclear whether these identified via bulk transcriptomics are mutually exclusive or not. Here, we perform pairwise correlations among individual genes gene signatures corresponding show that not distinctly antagonistic either scRNA-seq data. We observed proneural (or neural progenitor-like)-mesenchymal axis most prominent pair, with other two lying on spectrum. These results reinforced through meta-analysis over 100 datasets as well terms functional association metabolic switching, cell cycle, immune evasion pathways. Finally, proneural-mesenchymal trend percolates relevant transcription factors patient survival. suggest rethinking characterization for more effective therapeutic targeting efforts.

Язык: Английский

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CMINNs: Compartment model informed neural networks — Unlocking drug dynamics

Computers in Biology and Medicine, Год журнала: 2024, Номер 184, С. 109392 - 109392

Опубликована: Ноя. 28, 2024

Язык: Английский

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Harnessing Flex Point Symmetry to Estimate Logistic Tumor Population Growth

Bulletin of Mathematical Biology, Год журнала: 2024, Номер 86(11)

Опубликована: Окт. 9, 2024

Язык: Английский

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