Medicine International,
Год журнала:
2024,
Номер
4(6)
Опубликована: Авг. 14, 2024
In
the
present
study,
clinical
findings
that
interfere
with
immediate
return
to
activity
following
volar
locking
plate
(VLP)
fixation
for
distal
radius
fractures
were
investigated.
A
total
of
95
patients
who
underwent
VLP
fracture
between
July,
2014
and
January,
2022
divided
into
a
good
group
(good
score
outcome;
n=86;
22
males
64
females;
median
age,
61
years)
poor
(poor
n=8;
8
63.6
according
quartiles
disabilities
arm,
shoulder
hand
(Q-DASH)
score,
at
1
month
fixation.
The
duration
from
injury
surgery,
direction
dislocation
radiographic
parameters
[radial
inclination
(RI),
tilt
(VT)
ulnar
variance
(UV)]
time
examined.
Radiographic
(RI,
VT
UV),
range
motion
wrist
joint,
grip
strength
ratio
visual
analog
scale
(VAS)
also
These
compared
among
both
groups.
Moreover,
logistic
regression
analysis
was
performed
determine
whether
these
factors
independently
associated
Q-DASH
At
injury,
displacement
significantly
higher
in
(VT,
-23.8˚;
UV,
4.2
mm)
than
-6.5˚;
P=0.02;
1.3
mm;
P=0.01).
No
differences
other
observed
fixation,
(17.2%)
lower
(43.8%,
P<0.001),
while
VAS
(5.6)
(2.4,
P<0.001).
Logistic
revealed
UV
(P<0.05),
(P<0.001)
pain
(VAS
score)
all
score.
On
whole,
study
suggests
large
amounts
displacement,
weakness
post-operative
can
be
interfering
immediately
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107591 - 107591
Опубликована: Янв. 1, 2025
The
hallmarks
of
aging
encompass
a
variety
molecular
categories
(genomic,
telomeric,
and
epigenetic),
organelles
(proteostasis,
autophagy,
mitochondria),
cellular
components
(including
stem
cells),
systems
(such
as
intercellular
communication
chronic
inflammation),
environmental
factors
(dysbiosis
nutrient
sensing).
These
play
crucial
role
in
the
process.
Despite
their
intricate
interconnections,
relationships
among
remain
unclear.
Although
boundaries
between
these
may
be
indistinct,
they
exhibit
interdependence,
with
influence
one
hallmark
extending
to
others.
Building
on
this
foundation,
we
investigated
interrelations
various
provided
systematic
overview
logical
relationships,
proposing
that
plays
Exosomes
function
primary
mode
significantly
impact
Therefore,
propose
utilizing
exosomes
valuable
tools
for
understanding
mechanisms
addressing
age-related
concerns.
represent
novel
approach
treatment
diagnosis
aging-related
conditions
animals.
Furthermore,
our
research
reveals
exocytosis
young
nematodes
slows
process,
while
aged
has
opposite
effect,
accelerating
aging.
In
conclusion,
act
messengers
maintenance
healthy
process
link
indicators
well-being.
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Апрель 27, 2024
In
bone
tissue
engineering,
the
search
for
improved
repair
methods
is
crucial,
given
drawbacks
of
traditional
strategies
like
donor
site
issues
and
immune
rejection.
Addressing
these
challenges,
this
paper
introduces
an
innovative
GelMA/Bentonite
composite
bioink
3D
bioprinting,
designed
to
create
scaffolds
that
closely
emulate
native
tissue.
GelMA
selected
its
biocompatibility
modifiable
mechanics,
while
Bentonite's
mineral
richness
ion
exchange
capacity
are
harnessed
enhance
scaffold
structure
promote
osteogenic
microenvironment.
This
research
marks
inaugural
incorporation
Bentonite
into
a
bioink,
significant
stride
forward
established
safety
in
pharmaceuticals
versatility
across
industries.
formulation
signifies
breakthrough
aiming
improve
osteointegration
regeneration
Combining
with
key
step
creating
bioinks
healing,
potentially
transforming
scaffold-based
pioneering
use
natural
nanomaterials
medicine.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101558 - 101558
Опубликована: Фев. 5, 2025
The
regulation
of
bone
metabolic
microenvironment
imbalances
in
diseases
such
as
osteoporosis,
defects,
infections,
and
tumors
remains
a
significant
challenge
orthopedics.
Therefore,
it
has
become
urgent
to
develop
biomaterials
with
effective
microenvironmental
regulatory
functions.
Zeolites,
advanced
biomedical
materials,
possess
distinctive
physicochemical
properties
multi-level
pore
structures,
adjustable
frameworks,
easily
modifiable
surfaces,
excellent
adsorption
capabilities.
These
advantageous
characteristics
give
zeolites
broad
application
prospects
regulating
the
microenvironment.
this
paper
first
classifies
used
regulate
based
on
their
topological
structures
compositional
frameworks.
Subsequently,
provides
detailed
description
modification
strategies
for
zeolite
materials
aimed
at
Next,
comprehensive
summary
was
provided
preparation
Additionally,
focuses
specific
applications
conditions
imbalance,
orthopedic
tumors,
highlighting
potential
enhancing
osteogenic
microenvironments,
controlling
treating
tumors.
Finally,
outlines
challenges
associated
This
review
comprehensively
summarizes
regulation,
aiming
provide
guidance
future
research
development.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 17, 2025
Bone
defect,
a
common
orthopedic
condition,
is
characterized
by
lengthy
and
impactful
treatment
period,
posing
considerable
challenge
in
clinical
settings.
Medical
technology
has
advanced
notably,
effectively
treated
an
increasing
number
of
patients
with
bone
defects.
Consequently,
there
been
explosion
research
articles
on
regeneration,
including
substantial
the
application
exosomes.
Exosomes,
especially
those
derived
from
stem
cells,
have
confirmed
to
be
effective
regeneration
garnered
widespread
attention
last
decade.
Therefore,
this
study
conducted
bibliometric
analysis
publications
related
exosomes
for
regeneration.
The
objectives
are
explore
development
history
hotspots
field
over
past
10
years,
predict
future
trends,
provide
guidance
subsequent
research.
Web
Science
Core
Collection
(WoSCC)
database
was
searched
published
1
January
2014,
31
December
2023.
collected
literature
analyzed
using
software
such
as
Microsoft
Excel,
CiteSpace
6.3R1,
VOSviewer
1.6.20,
online
platform
(https://bibliometric.com).
A
total
3,004
2,729
institutions
68
countries
were
included
study.
increased
annually
China
most
prolific
country
field,
1,468
papers;
Shanghai
Jiao
Tong
University
(China)
institution
highest
(117
publications).
In
terms
authors,
Xin
Wang,
Yi
Zhang,
Yang
Wang
three
who
papers,
14
papers
each.
Co-citation
revealed
that
article
Valadi
H
2007
co-citations
(270
times
quotation).
Additionally,
focused
function
mechanism
action.
Furthermore,
importance
osteoblast
differentiation
angiogenesis
also
significant
scholars
field.
This
reviewed
achievements
utilizing
tools.
It
visualized
countries,
institutions,
journals
made
contributions
current
hotspots,
finally
explored
trends.
Osteoporosis
(OP)
is
a
systemic
disease
characterized
by
decreased
bone
density
and
quality,
leading
to
fragile
bones
osteoporotic
fractures
(OPF).
Conventional
treatments
for
OPF
often
exhibit
limited
therapeutic
efficacy
significant
side
effects.
Synthetic
biology-based
bacterial
extracellular
vesicles
(BEVs)
offer
safe
effective
alternative
treatment.
Here,
we
constructed
bioengineered
BEVs
loaded
with
pBMP-2-VEGF
(BEVs-BP)
encapsulated
them
together
IL-4
in
GelMA
hydrogels
form
IL-4/BEVs-BP@GelMA.
Initially,
alleviated
chronic
inflammation
modulating
immune
cells,
while
BEVs-BP
subsequently
enhanced
osteogenesis
vascularization
upregulating
BMP-2
VEGF
expression.
In
vitro,
IL-4/BEVs-BP@GelMA
polarized
M1
macrophages
toward
the
M2
phenotype,
osteogenesis,
increased
angiogenesis.
Moreover,
effectively
promoted
maturation
mineralization
of
organoids
vivo.
Finally,
successfully
accelerated
fracture
repair
mice.
summary,
developed
an
easy-to-build
powerful
biomaterial,
IL-4/BEVs-BP@GelMA,
which
offers
strategy
management.
