Self-adaptive bioactive scaffolds orchestrate diabetic microenvironment remodeling and vascularized bone regeneration

Composites Part B Engineering, Год журнала: 2024, Номер 286, С. 111771 - 111771

Опубликована: Авг. 17, 2024

Язык: Английский

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Carvacrol-loaded Premixed Calcium Phosphate Bone Cements with Exceptional Osteogenic and Antibacterial Properties to Heal Infected Bone Defects

Composites Part B Engineering, Год журнала: 2024, Номер 287, С. 111812 - 111812

Опубликована: Сен. 1, 2024

Язык: Английский

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Hydrophilic Silsesquioxane Nanocages Toughened Extracellular Matrix Biomimetic Poly(γ-Glutamic Acid) Multidimensional Self-Polymerizable and Osteogenic Hybrid Hydrogel for Osteoporotic Bone Regeneration

Composites Part B Engineering, Год журнала: 2024, Номер 284, С. 111713 - 111713

Опубликована: Сен. 1, 2024

Язык: Английский

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Ion-induced electrospinning of hierarchical spiderweb-like bioscaffolds

Composites Part B Engineering, Год журнала: 2024, Номер 284, С. 111729 - 111729

Опубликована: Июль 16, 2024

Язык: Английский

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Degradation Kinetics, Mechanisms, and Antioxidant Activity of PCL-Based Scaffolds with In Situ Grown Nanohydroxyapatite on Graphene Oxide Nanoscrolls

C – Journal of Carbon Research, Год журнала: 2025, Номер 11(1), С. 5 - 5

Опубликована: Янв. 3, 2025

Polycaprolactone (PCL) degradation is critical in bone tissue engineering, where scaffold must align with regeneration to ensure stability and integration. This study explores the effects of nanofillers, hydroxyapatite (nHA), graphene oxide nanoscrolls (GONS) on PCL-based kinetics. Both PHAP (nHA-PCL) PGAP (nHA-GONS-PCL) scaffolds exhibited changes relaxation-driven degradation, as indicated by adherence Korsmeyer–Peppas model (R2 = 1.00). showed lower activation energies (5.02–5.54 kJ/mol), promoting faster chain relaxation amorphous regions. scaffolds, higher (12.88–12.90 displayed greater resistance slower degradation. Differential scanning calorimetry (DSC) revealed that both nanofillers disrupted crystalline regions, shifting behavior from diffusion-based mechanisms zones, which was also reflected crystallization temperature (Tc) melting (Tm). Additionally, demonstrated antioxidant potential, decreased over time progressed. These results provide a mechanistic understanding how nanofiller-modulated dynamics can be strategically leveraged optimize performance, facilitating precise control rates bioactivity.

Язык: Английский

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Functionalized zeolite regulates bone metabolic microenvironment

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101558 - 101558

Опубликована: Фев. 5, 2025

The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, defects, infections, and tumors remains a significant challenge orthopedics. Therefore, it has become urgent to develop biomaterials with effective microenvironmental regulatory functions. Zeolites, advanced biomedical materials, possess distinctive physicochemical properties multi-level pore structures, adjustable frameworks, easily modifiable surfaces, excellent adsorption capabilities. These advantageous characteristics give zeolites broad application prospects regulating the microenvironment. this paper first classifies used regulate based on their topological structures compositional frameworks. Subsequently, provides detailed description modification strategies for zeolite materials aimed at Next, comprehensive summary was provided preparation Additionally, focuses specific applications conditions imbalance, orthopedic tumors, highlighting potential enhancing osteogenic microenvironments, controlling treating tumors. Finally, outlines challenges associated This review comprehensively summarizes regulation, aiming provide guidance future research development.

Язык: Английский

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Harnessing extracellular vesicles from Lactobacillus reuteri and Lactobacillus paracasei for synergistic osteoporosis therapy

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112255 - 112255

Опубликована: Фев. 1, 2025

Язык: Английский

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Particles Generated from Degrading Magnesium Implants Induce Bone Resorption

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112241 - 112241

Опубликована: Фев. 1, 2025

Язык: Английский

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ALP-Mimetic Cyclic Peptide Nanotubes: A Multifunctional Strategy for Osteogenesis and Bone Regeneration

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Alkaline phosphatase (ALP) plays a crucial role in bone mineralization by hydrolyzing organophosphates and releasing inorganic phosphate ions, facilitating hydroxyapatite formation. The imidazole ring the functional domain of ALP is critical for its catalytic activity mineralization. However, therapeutic application native hindered instability, short half-life, immunogenicity, variable efficacy. This work presents development ALP-mimetic cyclic-octapeptide (ALAKHKHP) nanotubes to promote osteogenic differentiation incorporation imidazole-rich histidine residues close proximity gives enzyme-mimetic characteristics. effectively catalyzed para-nitrophenyl (pNPP) hydrolysis, promoting vitro calcium deposition activity, which stimulated MC3T3-E1 preosteoblasts, as evidenced upregulation marker genes. demonstrated excellent cell migration, reactive oxygen species (ROS) scavenging, anti-inflammatory properties. biomimetic nanoscaffold provides promising alternative regeneration, without relying on enzymes, growth factors, or drugs.

Язык: Английский

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Revitalizing osteoporotic bone repair via multilevel ROS scavenging and osteoimmune regulating hydrogel

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112305 - 112305

Опубликована: Фев. 1, 2025

Язык: Английский

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