Zinc Oxide-Copper Sulfide Nanozyme Hydrogels for Bone Defect Repair by Modulating the Bone Immune Microenvironment and Promoting Osteogenesis/Angiogenesis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Bone defects caused by trauma, tumors, or infections pose significant challenges to clinical treatment because of the complex pathological microenvironment they create. Elevated levels inflammatory factors and reactive oxygen species (ROS) at defect site disrupt bone immune microenvironment, impeding regeneration. Concurrently, vascular damage frequently associated with leads hypoxia, further complicating therapeutic efforts. Although grafting remains a primary approach, its efficacy is limited these adverse conditions. In this study, ZnO-CuS/F127 nanozyme hydrogel multiple enzymatic activities was manufactured for repair via modulation promotion osteo-/angiogenesis, which accomplished encapsulation ZnO-CuS nanoflowers synthesized calcination into F127 matrix. bimetallic nanoenzymes exhibit robust catalase (CAT) superoxide dismutase-like activities, enabling effective scavenging diverse ROS in vitro. cellular assays, protected marrow mesenchymal stem cells [bone (BMSCs)] from ROS-induced cytotoxicity promoted macrophage polarization toward anti-inflammatory M2 phenotype, thus modulating microenvironment. The demonstrated potent proangiogenic pro-osteogenic effects, attributed ability upregulate Wnt/β-catenin signaling pathway while inhibiting NF-κB BMSCs, as confirmed RNA sequencing. vivo, exhibited exceptional hemostatic performance facilitated mouse hemorrhage rat models maintaining high biocompatibility low cytotoxicity. This study highlights use promising strategy repair. By promoting angiogenesis osteogenesis, multifunctional offers innovative insights potential solution addressing multifaceted

Язык: Английский

Tendon injury repair strategy driven by supramolecular hydrogen bonding and dynamic covalent bond self-assembly microspheres

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162726 - 162726

Опубликована: Апрель 1, 2025

Язык: Английский