Опубликована: Ноя. 15, 2024
Язык: Английский
Molecules, Год журнала: 2025, Номер 30(2), С. 429 - 429
Опубликована: Янв. 20, 2025
Liver-expressed antimicrobial peptide 2 (LEAP-2) was originally discovered as an that plays a vital role in the host innate immune system of various vertebrates. Recent research LEAP-2 endogenous antagonist and inverse agonist GHSR1a receptor. By acting competitive to ghrelin, influences energy balance metabolic processes via ghrelin–GHSR1a signaling pathway. alone or LEAP-2/ghrelin molar ratio showed potential therapeutic targets for obesity, diabetes, disorders. This review explores recent advances modulation regulation, highlighting its treating above diseases.
Язык: Английский
Процитировано
1
Expert Systems with Applications, Год журнала: 2025, Номер unknown, С. 126608 - 126608
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Psychiatric Research, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Behavioral Addictions, Год журнала: 2025, Номер unknown
Опубликована: Июнь 5, 2025
Abstract Background and aims Gambling Disorder (GD) is associated with maladaptive decision-making, possibly driven by biases in learning confidence judgments. While prior research report abnormal rates heightened overconfidence GD, the affected cognitive mechanism producing these joint deficits has so far remained unidentified. Our study to fill this gap using a recently established reinforcement (RL) experimental computational framework linking processes, outcome-valence effects Methods We pre-registered tested hypotheses that GD patients exhibit increased (over)confidence confirmatory bias, outcome valence on choice accuracy judgements 18 participants 19 matched controls. Results our findings replicated main behavioral patterns of choices judgments, confirmed their foundations, we did not find any group differences between controls GD. Discussion Conclusions The current speak inconsistent abnormalities Systematic necessary better understand influence mediating factors such as disorder-related idiosyncrasies (e.g. skill- vs chance-based preferences) further clarify if, when how are people
Язык: Английский
Процитировано
0
Addictive Behaviors, Год журнала: 2024, Номер 153, С. 107968 - 107968
Опубликована: Фев. 9, 2024
Neurobiological characteristics have been identified regarding the severity of gambling disorder (GD). The aims this study were: (1) to examine, through a path analysis, whether there was relationship between neuroendocrine features, potentially mediational GD variables, and severity, (2) associate with severity-related variables according preferences. Methods: sample included 297 outpatients GD. We analyzed endocrine concentrations different appetite-related hormones (ghrelin, liver antimicrobial peptide 2 [LEAP-2], leptin, adiponectin), neuropsychological performance (working memory, cognitive flexibility, inhibition, decision making, premorbid intelligence). Path analysis assessed mechanisms features including (impulsivity traits gambling-related distortions). Partial correlations evaluated associations impulsivity traits, related (DSM-5, South Oaks Gambling Screen, illness duration, Results: Lower adiponectin predicted greater while higher LEAP-2 more distortions. Likewise, better directly but worse associated Also, in non-strategic individuals GD, poor working memory expectancies predictive control. In strategic flexibility illusion control, inability stop gambling. Conclusions: These results provide updated information about comprehension interaction clinical Thus, neurobiological functions seem be strongly severity.
Язык: Английский
Процитировано
1
Addictive Behaviors, Год журнала: 2024, Номер unknown, С. 108190 - 108190
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
0