Social trauma engages lateral septum circuitry to occlude social reward

Nature, Год журнала: 2022, Номер 613(7945), С. 696 - 703

Опубликована: Ноя. 30, 2022

Abstract In humans, traumatic social experiences can contribute to psychiatric disorders 1 . It is suggested that trauma impairs brain reward function such behaviour no longer rewarding, leading severe avoidance 2,3 rodents, the chronic defeat stress (CSDS) model has been used understand neurobiology underlying susceptibility versus resilience following trauma, yet little known regarding its impact on 4,5 Here we show that, CSDS, a subset of male and female mice, termed susceptible (SUS), avoid interaction with non-aggressive, same-sex juvenile C57BL/6J mice do not develop context-dependent encounters them. Non-social stressors have effect in either sex. Next, using whole-brain Fos mapping, vivo Ca 2+ imaging whole-cell recordings, identified population stress/threat-responsive lateral septum neurotensin (NT LS ) neurons are activated by interactions only SUS but resilient or unstressed control mice. Optogenetic chemogenetic manipulation NT their downstream connections modulates reward. Together, these data suggest previously rewarding targets possibly perceived as threats resulting from hyperactive occlude processing.

Язык: Английский

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Social circuits and their dysfunction in autism spectrum disorder

Molecular Psychiatry, Год журнала: 2023, Номер 28(8), С. 3194 - 3206

Опубликована: Авг. 1, 2023

Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social many different behavioral paradigms have been used for investigating their neural circuit bases. behavior is highly vulnerable to brain network dysfunction caused by neurological neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms abnormal potential therapeutic targets treatment. In this review, we outline recent progress key findings on underlying behavior, particular emphasis rodent studies that monitor manipulate the activity specific circuits using modern systems neuroscience approaches. mediated distributed brain-wide among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, insular (IC)) subcortical nucleus accumbens, basolateral amygdala (BLA), ventral tegmental area) structures, influenced multiple neuromodulatory oxytocin, dopamine, serotonin). We particularly draw special attention IC unique area mediates multisensory integration, encoding ongoing interaction, decision-making, emotion, empathy. Additionally, synthesis demonstrates dysfunctions in mPFC-BLA circuitry neuromodulation prominent. Pharmacological rescues local or systemic oral) administration drugs provided valuable clues developing new agents ASD. Future efforts technological advances will push forward next frontiers field, elucidation inter-brain dynamics during real virtual interactions, establishment circuit-based therapy affecting functions.

Язык: Английский

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A distinct cortical code for socially learned threat

Nature, Год журнала: 2024, Номер 626(8001), С. 1066 - 1072

Опубликована: Фев. 7, 2024

Язык: Английский

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Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice

Cell, Год журнала: 2023, Номер 186(19), С. 4152 - 4171.e31

Опубликована: Сен. 1, 2023

Язык: Английский

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Sexually dimorphic control of affective state processing and empathic behaviors

Neuron, Год журнала: 2024, Номер 112(9), С. 1498 - 1517.e8

Опубликована: Март 1, 2024

Recognizing the affective states of social counterparts and responding appropriately fosters successful interactions. However, little is known about how are expressed perceived they influence decisions. Here, we show that male female mice emit distinct olfactory cues after experiencing distress. These activate neural circuits in piriform cortex (PiC) evoke sexually dimorphic empathic behaviors observers. Specifically, PiC → PrL pathway activated observers, inducing a preference for distressed counterpart. Conversely, MeA evoking excessive self-grooming behaviors. pathways originate from non-overlapping neuron populations with gene expression signatures regulated by transcription factors sex hormones. Our study unveils internal processed through mechanisms at molecular, cellular, circuit levels offers insights into underpinning differences higher brain functions.

Язык: Английский

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Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies

Biological Psychiatry, Год журнала: 2024, Номер 96(2), С. 85 - 94

Опубликована: Март 13, 2024

Язык: Английский

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Information sharing within a social network is key to behavioral flexibility—Lessons from mice tested under seminaturalistic conditions

Science Advances, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 3, 2025

Being part of a social structure offers chances for learning vital survival and reproduction. Nevertheless, studying the neural mechanisms under laboratory conditions remains challenging. To investigate impact socially transmitted information about rewards on individual behavior, we used Eco-HAB, an automated system monitoring voluntary behavior group-housed mice seminaturalistic conditions. In these settings, male spontaneously form networks, with individuals occupying diverse positions. We show that rewarded group member’s scent affects ability conspecifics to search in familiar novel environments. The scent’s depends animal’s position. Furthermore, disruption neuronal plasticity prelimbic cortex (PL) disrupts networks animals’ interest related rewards; only latter is blocked by acute PL inhibition. This experimental design represents cutting-edge approach brain learning.

Язык: Английский

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Imagining the future self through thought experiments

Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(5), С. 446 - 455

Опубликована: Фев. 17, 2023

The ability of the mind to conceptualize what is not present essential. It allows us reason counterfactually about might have happened had events unfolded differently or another course action been taken. think happen - perform 'Gedankenexperimente' (thought experiments) before we act. However, cognitive and neural mechanisms mediating this are poorly understood. We suggest that frontopolar cortex (FPC) keeps track evaluates alternative choices (what done), whereas anterior lateral prefrontal (alPFC) compares simulations possible future scenarios do) their reward values. Together, these brain regions support construction suppositional scenarios.

Язык: Английский

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An operant social self-administration and choice model in mice

Nature Protocols, Год журнала: 2023, Номер 18(6), С. 1669 - 1686

Опубликована: Март 24, 2023

Язык: Английский

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Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Neuropsychopharmacology, Год журнала: 2024, Номер 49(6), С. 993 - 1006

Опубликована: Янв. 17, 2024

Язык: Английский

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