Clocks & Sleep,
Год журнала:
2023,
Номер
5(4), С. 686 - 716
Опубликована: Ноя. 17, 2023
Explaining
the
complex
structure
and
dynamics
of
sleep,
which
consist
alternating
physiologically
distinct
nonREM
REM
sleep
episodes,
has
posed
a
significant
challenge.
In
this
study,
we
demonstrate
that
single-wave
model
concept
captures
distinctly
different
overnight
four
primary
measures-the
duration
intensity
episodes-with
high
quantitative
precision
for
both
regular
extended
sleep.
The
also
accurately
predicts
how
these
polysomnographic
measures
respond
to
deprivation
or
abundance.
Furthermore,
passes
ultimate
test,
as
its
prediction
leads
novel
experimental
finding-an
invariant
relationship
between
episodes
product
remains
constant
over
consecutive
cycles.
These
results
suggest
functional
unity
establishing
comprehensive
framework
understanding
normal
disorders.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Фев. 20, 2023
Abstract
Sleep
behavior
is
conserved
throughout
evolution,
and
sleep
disturbances
are
a
frequent
comorbidity
of
neuropsychiatric
disorders.
However,
the
molecular
basis
underlying
dysfunctions
in
neurological
diseases
remains
elusive.
Using
model
for
neurodevelopmental
disorders
(NDDs),
Drosophila
Cytoplasmic
FMR1
interacting
protein
haploinsufficiency
(
Cyfip
85.1/
+
),
we
identify
mechanism
modulating
homeostasis.
We
show
that
increased
activity
sterol
regulatory
element-binding
(SREBP)
flies
induces
an
increase
transcription
wakefulness-associated
genes,
such
as
malic
enzyme
Men
causing
disturbance
daily
NADP
/NADPH
ratio
oscillations
reducing
pressure
at
night-time
onset.
Reduction
SREBP
or
enhances
rescues
deficits,
indicating
causative
deficits
heterozygous
flies.
This
work
suggests
modulation
metabolic
axis
new
avenue
worth
exploring
its
therapeutic
potential
Journal of Experimental Biology,
Год журнала:
2024,
Номер
227(11)
Опубликована: Июнь 1, 2024
ABSTRACT
Evidence
of
behavioural
sleep
has
been
observed
in
every
animal
species
studied
to
date,
but
current
knowledge
the
behaviour,
neurophysiology
and
ecophysiology
associated
with
is
concentrated
on
mammals
birds.
Fish
are
a
hugely
diverse
group
that
can
offer
novel
insights
into
variety
sleep-related
behaviours
across
environments,
ecophysiological
relevance
fish
largely
overlooked.
Here,
we
systematically
reviewed
literature
assess
breadth
sleep,
surveyed
physiological
effects
sleep.
We
also
discuss
possible
ways
which
unstudied
external
factors
may
alter
behaviours.
For
example,
predation
risk
patterns,
as
shown
mammalian,
avian
reptilian
species.
Other
environmental
–
such
water
temperature
oxygen
availability
have
potential
patterns
differently
than
for
terrestrial
endotherms.
Understanding
ecological
influences
vital,
deprivation
affect
waking
behaviour
fitness
owing
cognitive
impairments,
possibly
affecting
phenomena
sensitivity
stressors
not
considered.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 13, 2023
ABSTRACT
Sleep
is
observed
in
most
animals,
which
suggests
it
subserves
a
fundamental
process
associated
with
adaptive
biological
functions.
However,
the
evidence
to
directly
associate
sleep
specific
function
lacking,
part
because
not
single
many
animals.
In
humans
and
other
mammals,
different
stages
have
traditionally
been
identified
using
electroencephalograms
(EEGs),
but
such
an
approach
feasible
animals
as
insects.
Here,
we
perform
long-term
multichannel
local
field
potential
(LFP)
recordings
brains
of
behaving
flies
undergoing
spontaneous
bouts.
We
developed
protocols
allow
for
consistent
spatial
LFPs
across
multiple
flies,
allowing
us
compare
LFP
activity
awake
periods
further
same
induced
sleep.
Using
machine
learning,
uncover
existence
distinct
temporal
explore
spectral
features
fly
brain.
Further,
analyze
electrophysiological
correlates
micro-behaviours
certain
stages.
confirm
stage
rhythmic
proboscis
extensions
show
that
this
sleep-related
behavior
differ
significantly
from
those
during
wakefulness,
indicating
dissociation
between
brain
states
wherein
these
behaviors
reside.
npj Digital Medicine,
Год журнала:
2024,
Номер
7(1)
Опубликована: Май 10, 2024
Abstract
Sleep
disturbances
profoundly
affect
the
quality
of
life
in
individuals
with
neurological
disorders.
Closed-loop
deep
brain
stimulation
(DBS)
holds
promise
for
alleviating
sleep
symptoms,
however,
this
technique
necessitates
automated
stage
decoding
from
intracranial
signals.
We
leveraged
overnight
data
121
patients
movement
disorders
(Parkinson’s
disease,
Essential
Tremor,
Dystonia,
Huntington’s
and
Tourette’s
syndrome)
whom
synchronized
polysomnograms
basal
ganglia
local
field
potentials
were
recorded,
to
develop
a
generalized,
multi-class,
specific
decoder
–
BGOOSE
.
This
generalized
model
achieved
85%
average
accuracy
across
disease
conditions,
even
presence
recordings
different
targets.
Furthermore,
we
also
investigated
role
electrocorticography
on
performances
proposed
an
optimal
map,
which
was
shown
facilitate
channel
selection
performances.
emerges
as
powerful
tool
decoding,
offering
exciting
precision
delivery
DBS
better
management
Abstract
Sleep
occurs
in
all
animals
but
its
amount,
form,
and
timing
vary
considerably
between
species
individuals.
Currently,
little
is
known
about
the
basis
for
these
differences,
part,
because
we
lack
a
complete
understanding
of
brain
circuitry
controlling
sleep–wake
states
markers
cell
types
which
can
identify
similar
circuits
across
phylogeny.
Here,
I
explain
utility
an
“Evo-devo”
approach
comparative
studies
sleep
regulation
function
as
well
medicine.
This
focuses
on
evolutionary
ancient
transcription
factors
act
master
controllers
cell-type
specification.
Studying
developmental
factor
cascades
novel
clusters
control
wakefulness,
reveal
mechanisms
differences
timing,
expression,
timepoint
evolution
when
different
neurons
appeared.
Spatial
transcriptomic
studies,
based
will
greatly
aid
this
approach.
Conserved
pathways
regulate
mice,
Drosophila,
C.
elegans.
Members
LIM
Homeobox
(Lhx)
gene
family
specification
circadian
forebrain
hypothalamus.
Increased
Lhx9
activity
may
account
increased
orexin/hypocretin
reduced
Mexican
cavefish.
Other
families
specify
brainstem,
hypothalamus,
basal
forebrain.
The
expression
allows
generation
specific
transplantation
approaches.
Furthermore,
mutations
are
linked
to
variation
duration
humans,
risk
restless
legs
syndrome,
sleep-disordered
breathing.
paper
part
“Genetic
other
molecular
underpinnings
sleep,
disorders,
rhythms
including
translational
approaches”
collection.
Abstract
Sleep
in
mammals
is
broadly
classified
into
two
different
categories:
rapid
eye
movement
(REM)
sleep
and
slow
wave
(SWS),
accordingly
REM
SWS
are
thought
to
achieve
a
set
of
functions.
The
fruit
fly
Drosophila
melanogaster
increasingly
being
used
as
model
understand
functions,
although
it
remains
unclear
if
the
brain
also
engages
kinds
well.
Here,
we
compare
commonly
approaches
for
studying
experimentally
Drosophila:
optogenetic
activation
sleep-promoting
neurons
provision
drug,
Gaboxadol.
We
find
that
these
sleep-induction
methods
have
similar
effects
on
increasing
duration,
but
divergent
activity.
Transcriptomic
analysis
reveals
drug-induced
deep
(‘quiet’
sleep)
mostly
downregulates
metabolism
genes,
whereas
‘active’
upregulates
wide
range
genes
relevant
normal
waking
This
suggests
optogenetics
pharmacological
induction
promote
features
sleep,
which
engage
sets
their
respective
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 20, 2023
Explaining
the
complex
structure
and
dynamics
of
sleep,
which
consist
alternating
physiologically
distinct
NonREM
REM
sleep
episodes,
has
posed
a
significant
challenge.
In
this
study,
we
demonstrate
that
single
wave
model
concept
captures
distinctly
different
overnight
four
primary
measures
-
duration
intensity
episodes
with
high
quantitative
precision.
Additionally,
accurately
predicts
how
these
respond
to
deprivation
or
abundance.
Furthermore,
passes
ultimate
test,
as
its
prediction
leads
novel
experimental
finding—an
invariant
relationship
between
product
remains
constant
over
consecutive
cycles.
These
results
suggest
functional
unity
establishing
comprehensive
framework
for
understanding
normal
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 3, 2023
Abstract
Sleep
in
mammals
can
be
broadly
classified
into
two
different
physiological
categories:
rapid
eye
movement
(REM)
sleep
and
slow
wave
(SWS),
accordingly
REM
SWS
are
thought
to
achieve
a
set
of
functions.
The
fruit
fly
Drosophila
melanogaster
is
increasingly
being
used
as
model
understand
functions,
although
it
remains
unclear
if
the
brain
also
engages
kinds
well.
Here,
we
compare
commonly
approaches
for
studying
experimentally
:
optogenetic
activation
sleep-promoting
neurons
provision
drug,
Gaboxadol.
We
find
that
these
sleep-induction
methods
have
similar
effects
on
increasing
duration,
but
divergent
activity.
Transcriptomic
analysis
reveals
drug-induced
deep
(‘quiet’
sleep)
mostly
downregulates
metabolism
genes,
whereas
‘active’
upregulates
wide
range
genes
relevant
normal
waking
This
suggests
optogenetics
pharmacological
induction
promote
features
sleep,
which
engage
sets
their
respective
