Current Opinion in Neurobiology,
Год журнала:
2024,
Номер
90, С. 102962 - 102962
Опубликована: Дек. 27, 2024
Autism
spectrum
disorders
(ASD)
are
substantially
heterogeneous
neuropsychiatric
conditions
with
over
a
thousand
associated
genetic
factors
and
various
environmental
influences,
such
as
infection
nutrition.
Additionally,
males
four
times
more
likely
than
females
to
be
affected.
This
heterogeneity
underscores
the
need
uncover
common
molecular
features
within
ASD.
Recent
studies
have
revealed
interactions
among
predispositions,
factors,
sex
that
may
critical
ASD
etiology.
review
focuses
on
emerging
evidence
for
impact
of
nutrients-particularly
zinc
amino
acids-on
ASD,
demonstrated
in
mouse
models
human
studies.
These
nutrients
been
shown
influence
synaptic
signaling,
dendritic
spine
formation,
behaviors
linked
autism.
Furthermore,
sex-based
differences
nutritional
requirements,
especially
acids,
contribute
observed
male
bias
autism,
indicating
between
could
integral
understanding
potentially
mitigating
symptoms.
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Фев. 24, 2025
Abstract
Background
The
pathogenesis
of
epilepsy
is
complex,
and
current
antiepileptic
drugs
do
not
effectively
control
the
seizures.
Cytoplasmic
polyadenylation
element-binding
protein
3
(CPEB3)
regulates
neuronal
excitability,
but
its
mechanism
action
in
clear.
In
this
paper,
we
investigated
effect
CPEB3
on
seizures
elucidated
underlying
molecular
mechanism.
Methods
Bioinformatics-based
search
for
genes
closely
associated
with
epilepsy.
Changes
expression
cellular
localization
were
verified
by
western
blotting
(WB)
Immunofluorescence
staining.
Subsequently,
adeno-associated
virus
was
employed
to
overexpress
or
knockdown
mice.
Behavioral
experiments
epileptic
phenotype,
affecting
phenotype
explored
WB,
real-time
quantitative
polymerase
chain
reaction
(RT-qPCR),
RNA
immunoprecipitation
(RIP),
chromatin
(CHIP).
Results
results
that
downregulated
model
mice
patients
temporal
lobe
co-expressed
neurons.
have
shown
negatively
addition,
exogenous
can
also
bind
mRNA
signal
transducer
activator
transcription
(STAT3)
inhibit
translation,
resulting
lower
levels
STAT3
p-STAT3,
reduced
nuclear
translocation
STAT3,
decreased
STAT3-mediated
transcriptional
activity
GluN1,
GluN2A,
GluN2B,
suppressing
NMDAR
subunits,
which
attenuate
seizure
degree
susceptibility
Conclusion
These
findings
suggest
may
influence
excitability
regulating
translation
activities
promote
NMDARs
expression.
This
could
offer
insights
into
novel
therapeutic
targets
ACS Medicinal Chemistry Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
This
patent
highlight
describes
a
series
of
novel
2-pyrrolidone
derivatives
that
act
as
negative
allosteric
modulators
(NAMs)
GluN2B-containing
N-methyl-d-aspartic
acid
receptors
(NMDARs).
These
compounds
target
the
ifenprodil
binding
site
NMDA
receptor
and
exhibit
enhanced
metabolic
stability
compared
to
traditional
phenolic-based
molecules.
Neurobiology of Disease,
Год журнала:
2025,
Номер
unknown, С. 106932 - 106932
Опубликована: Апрель 1, 2025
Autism
spectrum
disorders
(ASD)
are
neurodevelopmental
conditions
influenced
by
genetic
mutations,
dietary
factors,
and
sex-specific
mechanisms,
yet
the
interplay
of
these
factors
remains
elusive.
Here,
we
investigate
sex-biased
responses
mutant
mice
carrying
an
ASD-associated
mutation
in
Cttnbp2
to
zinc
supplementation
using
behavioral
assays,
proteomic
bioinformatic
analyses,
puromycin
pulse
labeling
assess
protein
synthesis.
Our
results
demonstrate
that
enhances
ribosomal
expression
synthesis
increases
density
size
dendritic
spines
male
mice,
alleviating
male-biased
social
deficits.
Analyses
neuronal
cultures
further
revealed
neurons,
not
astrocytes,
respond
enhance
In
contrast,
female
mutants
exhibit
resilience
differential
intake,
even
under
deprivation.
Elevated
mTOR
phosphorylation
increased
levels
translational
initiation
brains
may
provide
a
protective
mechanism,
reducing
their
sensitivity
deficiency.
mutations
heighten
vulnerability
deprivation,
impairing
behaviors.
These
findings
highlight
zinc-regulated
as
critical
mediators
ASD
phenotypes,
offering
new
insights
into
interventions.
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1140 - 1140
Опубликована: Май 8, 2025
Glycine
(Gly)
is
a
peculiar
neurotransmitter
(NT)
in
the
Central
Nervous
System
(CNS)
exhibiting
dual
functions:
it
mostly
inhibitory,
different
CNS
areas,
when
activates
ionotropic
Gly
receptors
(GlyRs)
[...]
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Май 12, 2025
Late-life
depression
(LLD)
is
a
major
depressive
disorder
that
highly
prevalent
among
older
people,
and
there
are
currently
no
validated
biomarkers
for
the
diagnosis
treatment
of
LLD.
Although
dysregulated
amino
acid
metabolism
has
been
increasingly
implicated
in
neuropsychiatric
disorders,
including
LLD,
most
existing
studies
overlook
chiral
nature
acids,
potentially
leading
to
inaccurate
or
incomplete
findings.
To
address
this
gap,
study
aimed
precisely
characterize
serum
profiles
patients
with
LLD
identify
potential
biomarkers.
Using
liquid
chromatography
tandem
mass
spectrometry
combined
derivatization
technique,
levels
34
acids
were
analyzed
53
37
healthy
controls
(HCs).
Significant
alterations
both
D-
L-enantiomers
observed,
reduced
D-methionine,
D-glutamic
acid,
D-threonine,
L-threonine,
alongside
elevated
glycine
compared
HCs.
The
combination
D-methionine
demonstrated
moderate
discriminatory
power
distinguishing
from
HCs,
an
area
under
curve
0.71.
Notably,
significantly
lower
antidepressant
responders
than
non-responders.
Additionally,
L-glutamic
differentially
associated
specific
cognitive
function
indicators.
These
findings
underscore
importance
accounting
chirality
biomarker
research
highlight
as
promising
candidates
prediction
response.
Ageing Research Reviews,
Год журнала:
2025,
Номер
109, С. 102775 - 102775
Опубликована: Май 20, 2025
Alzheimer's
disease
(AD)
is
still
an
excessively
complicated
neurological
disorder
that
impacts
millions
of
individuals
globally.
The
ideal
defensive
feature
the
central
nervous
system
(CNS)
intimate
junction
endothelial
cells,
which
functions
as
a
biological
barrier
to
safely
control
molecular
transport
throughout
brain.
blood-brain
(BBB)
comprises
tightly
locked
astrocyte
cell
junctions
on
CNS
blood
capillaries.
This
shields
brain
from
hazardous
toxins
by
preventing
entry
polar
medications,
and
ions.
However,
it
very
challenging
provide
any
treatment
for
neurodegenerative
illnesses
like
Alzheimer's.
Different
causative
mechanisms,
such
amyloid-β
(Aβ)
plaques,
tubulin-associated
unit
(Tau)
tangles,
neuroinflammation,
cause
neuronal
dysfunction,
leading
dementia
memory
loss
in
subject.
Several
treatments
are
approved
AD
therapy,
whereas
most
only
help
treat
related
symptoms.
Disappointingly,
current
remedies
have
not
been
able
progression
due
associated
side
effects.
Specific
pathogenic
mechanisms
involved
initiation
development
this
disease.
Therefore,
expected
survival
patient
with
limited
approximately
ten
years.
Hence,
mechanism
behind
must
be
understood
better
comprehend
improve
overall
rate.
review
highlighted
recent
insights
into
pathogenesis,
advancements
theragnostic
techniques,
existing
updates
clinical
trials,
emerging
innovations
medicinal
development.
That
has
helped
researchers
develop
other
strategies
address
shortcomings
traditional
medications.
