Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Open Access

Cassandra Avila,

Martin Sarter

Опубликована: Сен. 26, 2024

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson’s disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders.

Язык: Английский

Neuroplasticity in Parkinson’s disease DOI Creative Commons
Bogdan Ovidiu Popescu, Lucia Batzu, Pedro Ruiz

и другие.

Journal of Neural Transmission, Год журнала: 2024, Номер 131(11), С. 1329 - 1339

Опубликована: Авг. 5, 2024

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over last decades. Even though there no intervention yet to stop pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity a fundamental property human brain adapt both external changes internal insults pathological processes. In this paper we examine current knowledge concepts concerning at network level, cellular level molecular as parts neuroplastic response protein aggregation synapse loss neuronal in We analyse beneficial, compensatory effects, such augmentation nigral neurons efficacy, well negative, maladaptive levodopa-induced dyskinesia. Effects physical activity different treatments on neuroplasticity considered opportunity biomarkers identification use discussed.

Язык: Английский

Процитировано

8
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Open Access

Cassandra Avila,

Martin Sarter

Опубликована: Янв. 24, 2025

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson’s disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders.

Язык: Английский

Процитировано

0
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Creative Commons

Cassandra Avila,

Martin Sarter

eLife, Год журнала: 2025, Номер 13

Опубликована: Фев. 19, 2025

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain’s attention–motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic–DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign-trackers, STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic–DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson’s disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders.

Язык: Английский

Процитировано

0
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Creative Commons

Cassandra Avila,

Martin Sarter

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain's attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson's disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders. Adaptive behavior involves selection behaviorally significant capacity selected action. Neuronal cortex integration attentional motor functions. Here demonstrated primarily influences actions (cued stops). turning was especially powerful which, as psychological trait, deploy attention. Together, our demonstrate role input selection, they emphasize experimental biopsychological significance investigating attentional-motor interface context broader differences styles.

Язык: Английский

Процитировано

0
Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles DOI Creative Commons
Baram Sosis, Jonathan Rubin

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 27, 2024

Various mathematical models have been formulated to describe the changes in synaptic strengths resulting from spike-timing-dependent plasticity (STDP). A subset of these include a third factor, dopamine, which interacts with spike timing contribute at specific synapses, notably those cortex striatum input layer basal ganglia. Theoretical work analyze has largely focused on abstract issues, such as conditions under they may promote synchronization and weight distributions induced by inputs simple correlation structures, rather than scenarios associated tasks, generally not considered dopamine-dependent forms STDP. In this paper we introduce three dopamine-modulated STDP adapted previously proposed rules. We then analyze, mathematically simulations, their performance biologically relevant scenarios. test ability each maintain its weights face noise complete reward prediction action selection studying learned corresponding task setting. Interestingly, find that rule is well suited studied but falls short others. Different tasks therefore require different plasticity, yielding precise form mechanism present vary across regions striatum, other brain areas impacted are involved distinct computational functions.

Язык: Английский

Процитировано

0
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Open Access

Cassandra Avila,

Martin Sarter

Опубликована: Сен. 26, 2024

Turning on cue or stopping at a red light requires the detection of such cues to select action sequences, suppress action, in accordance with cue-associated rules. Cortico-striatal projections are an essential part brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In conjunction turn spike levels, presence single rendered be almost twice as likely contrast, multiple spikes predicted less GTs, STs, inhibition prelimbic-DMS attenuated rates, peaks, increased number spikes. These findings suggest that release is tightly controlled by neuronal activity. from DMS glutamatergic terminals may regulated other striatal circuitry, mediating suppression reward tracking.

Язык: Английский

Процитировано

0
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Open Access

Cassandra Avila,

Martin Sarter

Опубликована: Сен. 26, 2024

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson’s disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders.

Язык: Английский

Процитировано

0