Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Язык: Английский

Cross-Species Framework for Emotional Well-Being and Brain Aging DOI
Feng Lin, Janine M. Simmons, Adam Turnbull

и другие.

JAMA Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Importance Emotional well-being (EWB) is an emerging therapeutic target for managing and preventing symptoms associated with Alzheimer disease related dementias (ADRD). However, more research needed to establish causal inferences between brain changes, EWB, behavioral changes observed in typical aging ADRD. Observations This article presents a framework using cross-species neuroscience approach study EWB aging, adopting well-established biobehavioral model that highlights the reciprocal roles of ADRD symptoms. First, challenges opportunities this field are reviewed. Then, practical solution improve comparability animal human studies proposed. Conclusions Relevance The goal draw comprehensive parallels distinctions could enhance understanding mechanisms linking symptomatic disturbances across different species.

Язык: Английский

Процитировано

0
Gaze audits food items for bite points during human withdraw-to-eat movements DOI Creative Commons
Ian Q. Whishaw, Jessica R. Kuntz,

Hardeep Singh Ryait

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Food handling and eating are central to the skill of primate hand movements, their analysis can provide insights into evolutionary origins use its generalization other behaviors, such as tool use. Vision contributes differently reach, grasp, withdraw-to-eat components when eating, suggesting that these component movements controlled by different visuomotor networks with distinct histories. This study examines role gaze in mediating movement human participants various food items, including candy, donuts, carrots, bananas, apples, or pantomiming for some items. Eye-tracking frame-by-frame video analyses used describe gaze, duration, disengagement, eye blinking, preference each item. The results show first identifies points on a item dominant grasp then mouth bite. finger shaping both initial subsequent aid exposing targets grasping biting. comparison real pantomime suggests only items possess affordances elicit patterns associated identifying online grasps bites. findings discussed relation idea has feature-detector-like linking cues skilled orient

Язык: Английский

Процитировано

0
Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Язык: Английский

Процитировано

0