Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review

Journal of Inflammation Research, Год журнала: 2018, Номер Volume 11, С. 111 - 121

Опубликована: Март 1, 2018

Abstract: Studies examining post-traumatic stress disorder (PTSD) have either emphasized a relationship between PTSD and systemically pro-inflammatory state or identified link chronic disease. The aim of this study was to evaluate the evidence for individuals with systemic low-grade inflammation that has been proposed underlie disease development in population. authors conducted systematic review literature (January 2006 April 2017) accordance PRISMA statement following four databases: PubMed, MEDLINE, PsycINFO, SPORTDiscus Full Text. search strategy limited articles published peer-reviewed journals human studies. Nine studies measuring discussing its role were selected inclusion review. association markers evaluated by measurement variety inflammatory including acute-phase proteins, complement pro- anti-inflammatory cytokines, natural killer cells, white blood cells. In general, biomarkers elevated across groups. There is underpinned presence state. This may be mechanism associated increased risk From this, future research should focus on interventions help reduce inflammation, such as exercise. Keywords: C-reactive protein, CRP, disease, pro-inflammation, immune system

Язык: Английский

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Posttraumatic stress disorder: from diagnosis to prevention

Military Medical Research, Год журнала: 2018, Номер 5(1)

Опубликована: Сен. 19, 2018

Posttraumatic stress disorder (PTSD) is a chronic impairment that occurs after exposure to traumatic events. This can result in disturbance individual and family functioning, causing significant medical, financial, social problems. study selective review of literature aiming provide general outlook the current understanding PTSD. There are several diagnostic guidelines for PTSD, with most recent editions DSM-5 ICD-11 being best accepted. Generally, PTSD diagnosed according clusters symptoms occurring extreme stressors. Its pathogenesis multifactorial, including activation hypothalamic–pituitary–adrenal (HPA) axis, immune response, or even genetic discrepancy. The morphological alternation subcortical brain structures may also correlate symptoms. Prevention treatment methods vary from psychological interventions pharmacological medications. Overall, findings pertinent studies difficult generalize because heterogeneous patient groups, different events, criteria, designs. Future investigations needed determine which guideline inspection method early diagnosis strategies might prevent development

Язык: Английский

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The interaction between stress and chronic pain through the lens of threat learning

Neuroscience & Biobehavioral Reviews, Год журнала: 2019, Номер 107, С. 641 - 655

Опубликована: Окт. 14, 2019

Язык: Английский

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Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

Pharmacology & Therapeutics, Год журнала: 2022, Номер 239, С. 108195 - 108195

Опубликована: Апрель 27, 2022

Язык: Английский

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Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis

BMC Psychiatry, Год журнала: 2023, Номер 23(1)

Опубликована: Апрель 10, 2023

Posttraumatic Stress Disorder (PTSD) could potentially increase the risk of mortality, and there is a need for meta-analysis to quantify this association. This study aims determine extent which PTSD predictor mortality.

Язык: Английский

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Acute stress responses of autonomous nervous system, HPA axis, and inflammatory system in posttraumatic stress disorder

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Фев. 3, 2023

Abstract Posttraumatic stress disorder (PTSD) does not only have direct consequences for well-being, but it also comes with a significant risk severe somatic health consequences. A number of previous studies pointed to alterations in systems traumatized persons, as well the inflammatory system, which might be important links pathway between trauma, PTSD, and The aim this study was investigate acute responses PTSD patients compared healthy controls. Twenty-seven 15 controls were exposed Trier Social Stress Test (TSST), we measured salivary cortisol, alpha-amylase (sAA), plasma interleukin-6 (IL-6), heart rate variability (HRV) at different time points before, during after test. Results revealed similar controls, lower baseline cortisol levels higher IL-6 patients. Increases sAA significantly patients, while concentrations group intervention. HRV markedly decreased showed blunted response slower recovery TSST. These results confirm findings marked system dysregulations add literature on reactivity appears show system-specific changes. Overall, these implications our understanding potential resilience factors trauma.

Язык: Английский

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Affective immunology: where emotions and the immune response converge

Dialogues in Clinical Neuroscience, Год журнала: 2017, Номер 19(1), С. 9 - 19

Опубликована: Март 31, 2017

Affect and emotion are defined as "an essential part of the process an organism's interaction with stimuli." Similar to affect, immune response is "tool" body uses interact external environment. Thanks emotional immunological response, we learn distinguish between what like do not like, counteract a broad range challenges, adjust environment living in. Recent compelling evidence has shown that systems share more than similarity functions. This review article will discuss crosstalk these two need for new scientific area research called affective immunology. Research in this field allow better understanding appreciation basis mental disorders side diseases.

Язык: Английский

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The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health

Опубликована: Дек. 9, 2020

In one of my first acts as Governor, I established the role California Surgeon General.Among all myriad challenges facing our administration on day, addressing persistent to health and welfare people state-especially that youngest Californians-was an essential priority.We led with overwhelming scientific consensus upstream factors, including toxic stress social determinants health, are root causes many most harmful challenges, from heart disease homelessness.An issue so critical 40 million Californians deserved nothing less than a world-renowned expert advocate.Appointed in 2019 be firstever General, Dr. Nadine Burke Harris brought groundbreaking research expertise childhood trauma adversity State's efforts.In this new role, set three key priorities -early childhood, equity Adverse Childhood Experiences (ACEs) -and is working across give voice science evidence-based practices foundational success work state.The Office General has already strong programs, first-in-the-nation ACEs Aware initiative, partnership Department Health Care Services (DHCS), taking systematic science-based approach by training healthcare providers screen for children adults.We have also matched resolve funding.Through Initiative Advance Precision Medicine, we invested $9 demonstration projects address impacts using precision medicine approaches.California leading way public crisis because it one.This preventive measure improve societal outcomes state's residents generations come.As collectively face unprecedented confluence challenges-the COVID-19 pandemic, ensuing economic recession, ongoing national reckoning racial injustice, devastating wildfires exacerbated climate change-our state communities grateful Harris' leadership respond waves upon us.It responsibility meet moment.This report provides roadmap systemic equitable forward, based cross-sector partnerships.We must listen advised evidence clearly tells us cumulative adversity, particularly when experienced early life, cause some detrimental, longest lasting costly nation.This highlights how stress, if unaddressed, will cost over trillion dollars next 10 years due costs direct care life lost poor disability or death.It clear me implementing type evidence-based, responses necessary decrease burden not only ethical moral imperative, but vitality.This General's Report offers insights policymakers, scientists, providers, educators, advocates, advances solutions approaches better safety Golden now future.Furthermore, exceptional blueprint can truly stage well-being countless here elsewhere nation world.

Язык: Английский

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Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Ноя. 18, 2023

Abstract Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue understanding as well possibilities for intervention. Microbiome composition after exposure has been poorly examined regarding outcomes. We aimed determine whether gut microbiomes trauma-exposed emergency department patients who develop have dysfunctional microbiome profiles and discover potential associated mechanisms. performed metagenomic analysis on stool samples (n = 51) from a subset adults enrolled in Advancing Understanding RecOvery afteR traumA (AURORA) study. Two-, eight- twelve-week post-trauma outcomes stress disorder (PTSD) (PTSD checklist DSM-5), normalized depression scores (PROMIS Depression Short Form 8b) somatic symptom counts were collected. Generalized linear models created each outcome using microbial abundances relevant demographics. Mixed-effect random forest machine learning used identify associations between features encoded metabolic pathways metagenomics. Microbial species, including Flavonifractor plautii , Ruminococcus gnavus and, Bifidobacterium which prevalent commensal microbes, found be important predicting worse abundance data. Notably, through modeling pathways, highly predicted by decreased L-arginine related pathway genes increased citrulline ornithine pathways. Common species enriched individuals APNS. More notably, we identified mechanism reduces global arginine bioavailability, change that also demonstrated plasma with PTSD.

Язык: Английский

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Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 1, 2024

Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD co-morbid conditions. We investigated the genetic contributions PTSD, 18 diseases, 3 immune/inflammatory biomarkers. Univariate MiXeR was used contrast architectures of phenotypes. Genetic correlations were estimated using linkage disequilibrium score regression. Bi-directional, two-sample Mendelian randomization (MR) performed independent, genome-wide significant single nucleotide polymorphisms; inverse variance weighted median MR estimates evaluated. Sensitivity analyses uncorrelated (MR PRESSO) correlated horizontal pleiotropy (CAUSE) also performed. considerably more polygenic (10,863 influential variants) than (median 255 variants). However, evidenced correlation with nine three inflammatory had putative effects on thyroid disease (p = 0.00009) C-reactive protein (CRP) 4.3 × 10-7). Inferences not substantially altered by sensitivity analyses. Additionally, PTSD-autoimmune association remained in multivariable analysis adjusted genetically predicted biomarkers as potential mechanistic pathway variables. No a effect (all p values > 0.05). Although models supported associations CRP, adequate explain CRP 0.18). In summary, our results overlap inflammation. has disease, consistent existing epidemiologic evidence. A previously reported is potentially confounded genetics. Together, highlight nuanced links disorders, associated signatures, importance targeting related pathways protect against disability.

Язык: Английский

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