Siling Decoction Ameliorates Adenine-Induced Renal Fibrosis in Rats by the AKT/IKKβ/NFκB Signaling Pathway DOI
Lianlin Zeng, Yu‐Chuan Lin, Haixu Chen

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156228 - 156228

Опубликована: Ноя. 8, 2024

Язык: Английский

Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway DOI
Xiao Guo, Chen Liu, Zhen Dong

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156215 - 156215

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

1

The potential mechanism of pachymic acid in triple-negative breast cancer: a network pharmacology and vitro experiments DOI Creative Commons
Ming Liu, Li Zheng, Yang Zhang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract Background Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors, lack human epidermal growth factor receptor 2 (HER2) expression. Traditional Chinese medicine (TCM) has demonstrated promising efficacy in treating TNBC. Objective To explore mechanisms pachymic acid (PA) on Methods We gained Microarray data TNBC from Gene Expression Omnibus (GEO). The related targets PA were predicted screened using following six databases: Swiss Target, HERB, ETCM, BATMAN, HIT, PharmMapper. Verification Effective Targets TCGA. STRING interaction network analysis tool was used to create Protein-Protein Interaction (PPI) networks. Enrichment included Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). also conducted a pan-cancer analysis, tumor immune microenvironment molecular docking. Finally, we performed cell experimental, cytotoxicity assay, apoptosis proliferation migration invasion assays. Results found that potential for TNBC, with TOP2A likely being its target, platinum drug resistance possibly serving as KEGG pathway through which exerts therapeutic effects. By targeting TOP2A, involved processes such nuclear division, chromosome segregation, mitotic condensed formation, protein C-terminus binding. may exert effects microenvironment, involving elements Dendritic cells activated, Eosinophils, Macrophages M0, M1, T CD4 memory activated. vary across different subtypes three subtypes, TNBC-BL1, TNBC-Metaplastic, TNBC-BL2, are respond more favorably. Conclusion Our study provides compelling evidence holds significant promise agent primarily action influence

Язык: Английский

Процитировано

1

The Identification of New Pharmacological Targets for the Treatment of Glaucoma: A Network Pharmacology Approach DOI Creative Commons

Erika Giuffrida,

Chiara Bianca Maria Platania, Francesca Lazzara

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1333 - 1333

Опубликована: Окт. 5, 2024

Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration and death of retinal ganglion cells (RGCs), leading to blindness. Current glaucoma interventions reduce intraocular pressure but do not address neurodegeneration. In this effort, identify new pharmacological targets for management, we employed network pharmacology approach.

Язык: Английский

Процитировано

0

Uncovering the Therapeutic Target and Molecular Mechanism of Upadacitinib on Sjogren’s Syndrome DOI Creative Commons
Y. Yang, Yuan Liu, Xiaofen Li

и другие.

Biomedical Engineering and Computational Biology, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

Upadacitinib, a selective Janus associated kinase 1 (JAK-1) inhibitor, can be prescribed particularly for the clinical treatment with Crohn's disease or rheumatoid arthritis. It is clinically observed that upadacitinib has been found potential therapeutic effectiveness on Sjogren's syndrome (SS). However, anti-SS targets and mechanisms involved in remain uninvestigated.

Язык: Английский

Процитировано

0

Siling Decoction Ameliorates Adenine-Induced Renal Fibrosis in Rats by the AKT/IKKβ/NFκB Signaling Pathway DOI
Lianlin Zeng, Yu‐Chuan Lin, Haixu Chen

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156228 - 156228

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

0