Neurotoxicity of pesticides

Acta Neuropathologica, Год журнала: 2019, Номер 138(3), С. 343 - 362

Опубликована: Июнь 13, 2019

Язык: Английский

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Neurotoxicity in acute and repeated organophosphate exposure

Toxicology, Год журнала: 2018, Номер 408, С. 101 - 112

Опубликована: Авг. 23, 2018

Язык: Английский

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Organophosphorus Compounds at 80: Some Old and New Issues

Toxicological Sciences, Год журнала: 2017, Номер 162(1), С. 24 - 35

Опубликована: Дек. 5, 2017

Abstract One of the major classes pesticides is that organophosphates (OPs). Initial developments date back almost 2 centuries but it was only in mid-1940s OPs reached a prominent status as insecticides, that, albeit declining, still ongoing. are highly toxic to nontarget species including humans, primary effects being an acute cholinergic toxicity (responsible for thousands poisoning each year) and delayed polyneuropathy. Several issues current debate investigation on toxicology discussed this brief review. These include (1) possible additional targets OPs, (2) developmental neurotoxicants, (3) neurodegenerative diseases, (4) “aerotoxic syndrome,” (5) microbiome, (6) cancer. Some these have been debated studied some time, while others newer, suggesting study will remain important scientific public health issue years come.

Язык: Английский

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Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Chemical and Biological Technologies in Agriculture, Год журнала: 2022, Номер 9(1)

Опубликована: Янв. 15, 2022

Abstract Pesticides are classified into several groups based on their structure, including fungicides, insecticides, herbicides, bactericides, and rodenticides. toxic to both humans pests. For pest control, a very small amount of pesticides reach target Therefore, nearly all move through the environment exert adverse effects beneficial biota public health. These chemicals pollute water, soil, atmosphere ecosystem. Agricultural workers in greenhouses open fields, exterminators house pests, pesticide industry occupationally exposed pesticides. Pesticide exposure general population primarily happens consumption food water contaminated with residues; however, substantial can also occur outside or inside house. Currently, intelligent, responsive, biodegradable, biocompatible materials have attracted considerable interest for formulation green, safe, efficient It was indicated that utilizing nanotechnology design prepare targeted an environmentally responsive controlled release via chemical modifications compounds offers great potential creating new formulations. Furthermore, biopesticides include microbial pesticides, which naturally happening biochemical In addition, pesticidal substances generated by plants added genetic materials, i.e., plant-incorporated protectants (PIPs), emerged. Based foregoing evidence, various types summarized this review first time. Here, nano-pesticides discussed while focusing most recent findings safe nano-formulated nano-pesticides. Graphical

Язык: Английский

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Role of Environmental Toxicants on Neurodegenerative Disorders

Frontiers in Toxicology, Год журнала: 2022, Номер 4

Опубликована: Май 11, 2022

Neurodegeneration leads to the loss of structural and functioning components neurons over time. Various studies have related neurodegeneration a number degenerative disorders. Neurological repercussions can severe impacts on physical mental health patients. In recent past, various neurodegenerative ailments such as Alzheimer’s Parkinson’s illnesses received global consideration owing their occurrence. Environmental attributes been regarded main contributors neural dysfunction-related The majority neurological diseases are mainly prenatal postnatal exposure industrially produced environmental toxins. Some neurotoxic metals, like lead (Pb), aluminium (Al), Mercury (Hg), manganese (Mn), cadmium (Cd), arsenic (As), also pesticides metal-based nanoparticles, implicated in disease. contaminants known for ability produce senile or amyloid plaques neurofibrillary tangles (NFTs), which key features these dysfunctions. Besides, solvent is significant contributor diseases. This study recapitulates role neurotoxins with special emphasis major disorders

Язык: Английский

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Organophosphate pesticide residues in environmental and biological matrices: Occurrence, distribution and potential remedial approaches

Environmental Chemistry and Ecotoxicology, Год журнала: 2022, Номер 5, С. 9 - 23

Опубликована: Окт. 25, 2022

The prevalent occurrence of organophosphate pesticides in the environment is widely accompanied by severe adverse impacts on environmental matrices and humans owing to their bioaccumulation food chain or direct exposure. Despite intervention regulatory agencies levels pesticide residues, studies have shown that these congeners are still present human blood serum urine as well soil, sediments, water, air. This, therefore, requires adoption both conventional newly developed methods for total mitigation matrices. ubiquitous nature this group xenobiotics biological matrices, particularly at alarming concentrations reported reviewed studies, responsible its attendant health ecological impacts. Based available evidence, predominant source agricultural application. Although class persistent organic pollutants relatively less than organochlorine counterparts, nevertheless, neurotoxic effects cannot be undermined. Adequate measures must taken regulate storage usage farmlands. It also recommended more eco-friendly sustainable approaches should circumvent distressing pesticides. In review article, special attention given residues This article comprehensively discusses recent advances remediation whilst exploring future perspectives remedial approaches.

Язык: Английский

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Protein misfolding and amyloid nucleation through liquid–liquid phase separation

Chemical Society Reviews, Год журнала: 2024, Номер 53(10), С. 4976 - 5013

Опубликована: Янв. 1, 2024

Protein misfolding and amyloid aggregation, linked to neurodegenerative diseases, can result from liquid–liquid phase separation (LLPS) a subsequent liquid-to-solid transition. This represents LLPS as generic mechanism in nucleation.

Язык: Английский

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Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

International Journal of Epidemiology, Год журнала: 2017, Номер 47(1), С. 299 - 310

Опубликована: Окт. 9, 2017

Epidemiological studies have reported an increased risk of Parkinson's disease (PD) in farmers exposed to pesticides, but no clear conclusion can be drawn on the type pesticide and duration use associated with effect. In French agricultural cohort AGRICAN, we assessed associations between PD according types livestock crops grown, including exposure some active ingredients use. Self-reported history lifetime 13 5 animals were collected at enrolment (2005–07) among 181 842 participants. Exposure selected lifelong crop-exposure matrix PESTIMAT. Associations estimated by logistic regression livestock, adjusted for sex, age, educational level, smoking status alcohol consumption. was 1732 subjects (1.2%) cohort. Pesticide all activities [odds ratio (OR) = 1.31 (cattle) 1.79 (peas), P < 0.05]. Rotenone, diquat, paraquat several dithiocarbamates [OR (cuprobam) 1.57 (rotenone)], especially longest exposure. Our work suggests that is pesticides supports additional evidence association dithiocarbamate fungicides, rotenone herbicides diquat paraquat.

Язык: Английский

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Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Environmental Science and Pollution Research, Год журнала: 2020, Номер 27(21), С. 26036 - 26057

Опубликована: Май 12, 2020

Язык: Английский

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Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds

Frontiers in Neuroscience, Год журнала: 2017, Номер 10

Опубликована: Янв. 17, 2017

Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel additives. These potently inhibit acetylcholinesterase (AChE), the enzyme that inactivates acetylcholine at neuronal synapses, acute exposure to high OP levels can cause cholinergic crisis in humans animals. Evidence further suggests repeated lower insufficient crisis, frequently encountered occupational setting, also pose serious risks people. For example, multiple epidemiological studies have identified associations between neurodegenerative disease, psychiatric illness, sensorimotor deficits. Rigorous scientific investigation of basic science mechanisms underlying these findings requires valid preclinical models which tightly-regulated paradigms be correlated with neurotoxicity. Here, we review experimental currently field. We found animal simulating exposures do indeed show evidence neurotoxicity, utilization is helping illuminate OP-induced neurological sequelae. Still, work necessary evaluate levels, protection methods, treatment strategies, taken together could serve modify guidelines for improving workplace conditions globally.

Язык: Английский

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