Archives of Industrial Hygiene and Toxicology,
Год журнала:
2019,
Номер
70(2), С. 74 - 89
Опубликована: Июнь 1, 2019
Abstract
Pyrethroids
are
a
class
of
synthetic
insecticides
that
used
widely
in
and
around
households
to
control
the
pest.
Concerns
about
exposure
this
group
pesticides
now
mainly
related
their
neurotoxicity
nigrostriatal
dopaminergic
neurodegeneration
seen
Parkinson’s
disease.
The
main
neurotoxic
mechanisms
include
oxidative
stress,
inflammation,
neuronal
cell
loss,
mitochondrial
dysfunction.
targets
ion
channels.
However,
other
receptors,
enzymes,
several
signalling
pathways
can
also
participate
disorders
induced
by
pyrethroids.
aim
review
is
elucidate
involved
caused
pyrethroids
deltamethrin,
permethrin,
cypermethrin.
We
common
disease
therapy,
including
Nrf2,
Nurr1,
PPARγ,
how
they
affected
conclude
with
possibilities
be
addressed
future
research
novel
methods
protection
against
neurological
may
find
use
management/treatment
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 10, 2025
The
application
of
agrochemicals
such
as
organophosphate
pesticides
(OPPs)
has
several
benefits
in
agriculture
but
also
poses
great
risks
to
the
environment
and
human
well-being.
Thus,
this
study
was
conducted
determine
concentrations,
distribution
pattern,
relationships,
potential
sources
OPPs
agricultural
soils
vegetables
from
Delta
Central
District
(DCD)
Nigeria
provide
useful
information
for
pollution
history,
establishment
control
measures
risk
management.
Fourteen
were
determined
soil
using
a
gas
chromatograph-mass
selective
detector
(GC-MSD).
∑14
concentrations
varied
5.29
419
ng
g−1
0.69
130
vegetables.
On
average,
pirimiphos
methyl
(23.8
g−1)
diazinone
(4.74
dominant
respectively.
cumulative
ecological
assessed
toxicity-exposure-ratio
(TER)
quotient
(RQ)
approaches
revealed
that
there
high
organisms.
increasing
order
toxicity
organisms
chlorpyriphos
<
fenitrothion
while
health
suggested
adverse
non-carcinogenic
children
not
adults
exposed
these
Journal of Neurochemistry,
Год журнала:
2017,
Номер
142(3), С. 444 - 455
Опубликована: Май 13, 2017
Abstract
Gulf
War
Illness
(
GWI
)
is
a
chronic
multi‐symptom
disorder
affecting
veterans
of
the
1991
War.
Among
symptoms
are
those
associated
with
sickness
behavior,
observations
suggestive
underlying
neuroinflammation.
We
have
shown
that
exposure
mice
to
stress
hormone,
corticosterone
CORT
),
and
diisopropyl
fluorophosphate
DFP
as
nerve
agent
mimic,
results
in
marked
neuroinflammation,
findings
consistent
stress/neuroimmune
basis
.
Here,
we
examined
contribution
irreversible
reversible
acetylcholinesterase
AC
hE)
inhibitors
neuroinflammation
our
mouse
model
Male
C57
BL
/6J
received
4
days
(400
mg/L)
drinking
water
followed
by
single
dose
chlorpyrifos
oxon
CPO
;
8
mg/kg,
i.p.),
(4
pyridostigmine
bromide
(PB;
3
or
physostigmine
PHY
0.5
i.p.).
alone
caused
cortical
hippocampal
assessed
qPCR
tumor
necrosis
factor‐alpha,
IL
‐6,
C–C
chemokine
ligand
2,
‐1β,
leukemia
inhibitory
factor
oncostatin
M;
pretreatment
markedly
augmented
these
effects.
Additionally,
prior
enhanced
activation
signal
transducer,
transducer
activator
transcription
(STAT3).
In
contrast,
PB
did
not
produce
STAT3
activation.
While
all
CNS
‐acting
hE
,
decreased
brain
activity,
abrogated
effects
for
inhibitors.
Taken
together,
suggest
inhibitor‐induced
particularly
its
exacerbation
result
from
non‐cholinergic
compounds,
pointing
potentially
organophosphorylation
other
neuroimmune
targets.
image
Archives of Industrial Hygiene and Toxicology,
Год журнала:
2019,
Номер
70(2), С. 74 - 89
Опубликована: Июнь 1, 2019
Abstract
Pyrethroids
are
a
class
of
synthetic
insecticides
that
used
widely
in
and
around
households
to
control
the
pest.
Concerns
about
exposure
this
group
pesticides
now
mainly
related
their
neurotoxicity
nigrostriatal
dopaminergic
neurodegeneration
seen
Parkinson’s
disease.
The
main
neurotoxic
mechanisms
include
oxidative
stress,
inflammation,
neuronal
cell
loss,
mitochondrial
dysfunction.
targets
ion
channels.
However,
other
receptors,
enzymes,
several
signalling
pathways
can
also
participate
disorders
induced
by
pyrethroids.
aim
review
is
elucidate
involved
caused
pyrethroids
deltamethrin,
permethrin,
cypermethrin.
We
common
disease
therapy,
including
Nrf2,
Nurr1,
PPARγ,
how
they
affected
conclude
with
possibilities
be
addressed
future
research
novel
methods
protection
against
neurological
may
find
use
management/treatment
