The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 29, 2019

Abstract Functional lateralisation is a fundamental principle of the human brain. However, comprehensive taxonomy functional and its organisation in brain missing. Here, we report first complete map hemispheric asymmetries brain, reveal low dimensional structure, relationship with structural inter-hemispheric connectivity. Our results suggest that functions distributed along four axes: symbolic communication, perception/action, emotion, decision-making. The similarity between this finding recent work on neurological symptoms give rise to new hypotheses mechanisms support recovery after lesion. We also cortical regions showing task-evoked activity have reduced connections opposite hemisphere. This latter result suggests during evolution, size expansion led avoid excessive conduction delays hemispheres.

Язык: Английский

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Post-stroke deficit prediction from lesion and indirect structural and functional disconnection

Brain, Год журнала: 2020, Номер 143(7), С. 2173 - 2188

Опубликована: Май 21, 2020

Abstract Behavioural deficits in stroke reflect both structural damage at the site of injury, and widespread network dysfunction caused by structural, functional, metabolic disconnection. Two recent methods allow for estimation functional disconnection from clinical imaging. This is achieved embedding a patient’s lesion into an atlas connections healthy subjects, deriving ensemble that pass through lesion, thus indirectly estimating its impact on whole brain connectome. indirect assessment more readily available than direct measures connectivity obtained with diffusion MRI, respectively, it theory applicable to wide variety disorders. To validate relevance these methods, we quantified prediction behavioural prospective cohort 132 first-time patients studied 2 weeks post-injury (mean age 52.8 years, range 22–77; 63 females; 64 right hemispheres). Specifically, used multivariate ridge regression relate multiple domains (left visual, left motor, language, spatial attention, verbal memory) pattern or In subgroup patients, also measured alterations resting-state MRI. Both maps were predictive impairment all (0.16 < R2 0.58) except memory (0.05 0.06). Prediction was scarce negligible (0.01 0.18) visual field (R2 = 0.38), even though anatomically plausible domains. MRI subset clearly superior conclusion, successfully predicted post-stroke level comparable information. However, did not predict deficits, nor substitute measurements, especially cognitive

Язык: Английский

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Structural Disconnections Explain Brain Network Dysfunction after Stroke

Cell Reports, Год журнала: 2019, Номер 28(10), С. 2527 - 2540.e9

Опубликована: Сен. 1, 2019

Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed networks. It is often assumed FC disruptions reflect damage to specific cortical regions. However, an alternative explanation they the structural disconnection (SDC) white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, find SDC measures outperform measures, including putative critical regions, for explaining associated with stroke. We also identify core mode structure-function covariation links severity interhemispheric SDCs widespread across patients and correlates deficits in behavioral domains. conclude lesion's impact on connectome what determines its may play particularly important role mediating after

Язык: Английский

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The secret life of predictive brains: what’s spontaneous activity for?

Trends in Cognitive Sciences, Год журнала: 2021, Номер 25(9), С. 730 - 743

Опубликована: Июнь 16, 2021

Язык: Английский

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New imaging techniques and trends in radiology

Diagnostic and Interventional Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Radiography is a field of medicine inherently intertwined with technology.The dependency on technology very high for obtaining images in ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI).Although the reduction radiation dose not applicable US MRI, advancements have made it possible CT, ongoing studies aimed at further optimization.The resolution diagnostic quality obtained through each modality are steadily improving.Additionally, technological progress has significantly shortened acquisition times CT MRI.The use artificial intelligence (AI), which becoming increasingly widespread worldwide, also been incorporated into radiography.This can produce more accurate reproducible results examinations.Machine learning offers great potential improving image quality, creating distinct useful images, even developing new modalities.Furthermore, AI technologies prevalent MRI evaluation, generation, enhanced quality.

Язык: Английский

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Human brain connectivity: Clinical applications for clinical neurophysiology

Clinical Neurophysiology, Год журнала: 2020, Номер 131(7), С. 1621 - 1651

Опубликована: Апрель 22, 2020

Язык: Английский

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The future of human behaviour research

Nature Human Behaviour, Год журнала: 2022, Номер 6(1), С. 15 - 24

Опубликована: Янв. 27, 2022

Язык: Английский

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Subcortical-cortical dynamical states of the human brain and their breakdown in stroke

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Авг. 29, 2022

The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics the ultra-slow frequency range (<0.01-0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, identify Dynamic Functional States (DFSs), transient but recurrent clusters of and subcortical regions synchronizing frequencies. We observe shifts temporally coincident with clusters, flexibly either limbic (hippocampus/amygdala), or nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus cortex, provoke anomalies fraction times, dwell transitions DFSs, causing a bias toward abnormal network integration. Dynamical observed 2 weeks after stroke recover time contribute to explaining neurological impairment long-term outcome.

Язык: Английский

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Recovery of neural dynamics criticality in personalized whole-brain models of stroke

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июнь 27, 2022

Abstract The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal external inputs. Criticality thus provides function behavioral capabilities. We test this by examining the influence injury (strokes) on criticality neural dynamics estimated at level single participants using directly measured individual connectomes whole-brain models. Lesions engender a sub-critical state recovers over time in parallel with behavior. improvement is associated re-modeling specific white-matter connections. show personalized dynamical models poised track dynamics, alteration post-stroke, behavior participants.

Язык: Английский

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Effects of tactile feedback in post-stroke hand rehabilitation on functional connectivity and cortical activation: an fNIRS study

Biomedical Optics Express, Год журнала: 2025, Номер 16(2), С. 643 - 643

Опубликована: Янв. 6, 2025

Stroke-induced hand motor impairments have a significant impact on the daily lives of patients. Motor rehabilitation with tactile feedback (TF) shows promise as an effective intervention; however, its neural mechanisms are still not fully understood. The main objective this study was to examine effect brain functional responses during single movement session in post-stroke patients, using near-infrared spectroscopy (fNIRS). changes oxy- and deoxy-hemoglobin concentrations were recorded from bilateral prefrontal, motor, occipital areas 13 patients subacute recovery phase 15 healthy controls hand-grasping task TF no-TF. cortical activation responses, connectivity, network properties calculated explore specific response two grasping tasks. results showed that exhibited increased hemodynamic cortex tasks TF. However, prefrontal cortex, left sensorimotor right premotor area significantly lower compared (p < 0.05). Additionally, poorer overall function, reductions both clustering coefficient = 0.0016), reflecting local information transfer efficiency, transitivity 0.0053), representing global integration. A positive correlation observed between grip strength metrics (r 0.592, p 0.033), well 0.590, 0.034) indicating greater associated reduced transmission efficiency. These findings indicated can modulate activity learning integration, providing evidence for potential valuable tool stroke rehabilitation.

Язык: Английский

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