Spontaneous Beta Band Rhythms in the Predictive Coding of Natural Stimuli

The Neuroscientist, Год журнала: 2020, Номер 27(2), С. 184 - 201

Опубликована: Июнь 15, 2020

The regularity of the physical world and biomechanics human body movements generate distributions highly probable states that are internalized by brain in course a lifetime. In Bayesian terms, exploits prior knowledge, especially under conditions when sensory input is unavailable or uncertain, to predictively anticipate most likely outcome upcoming stimuli movements. These internal models, formed during development, yet still malleable adults, continuously adapt through learning novel Traditionally, neural beta (β) oscillations considered essential for maintaining sensorimotor cognitive representations, temporal coding expectations. However, recent findings show fluctuations β band power resting state strongly correlate between cortical association regions. Moreover, central (hub) regions form strong interactions over time with different regions/networks (dynamic core). centrality dynamic core predict global efficiency peaks suggesting mechanism network integration. Furthermore, this architecture surprisingly stable, both topology dynamics, observation ecological natural visual scenes, whereas synthetic temporally scrambled modify it. We propose spontaneous rhythms may function as long-term “prior” frequent environmental behaviors.

Язык: Английский

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Tumor-related neurocognitive dysfunction in patients with diffuse glioma: a retrospective cohort study prior to antitumor treatment

Neuro-Oncology Practice, Год журнала: 2019, Номер 6(6), С. 463 - 472

Опубликована: Апрель 22, 2019

Impairments in neurocognitive functioning (NCF) frequently occur glioma patients. Both the tumor and its treatment contribute to these impairments. We aimed quantify NCF patients before investigate which factors influence NCF.We performed a retrospective cohort study diffuse according STROBE (Strengthening Reporting of Observational Studies Epidemiology) criteria. All had undergone neuropsychological assessment as part routine clinical care, awake surgery. studied "overall NCF" 5 domains separately. For per domain, we analyses at 2 different levels outcome measures: (1) group level: mean cognitive sample, (2) individual percentage impaired multivariable logistic regression were associated with occurrence impairments.From our (2010-2016), 168 met all inclusion significantly affected level. The percentages impairments (-2SD) highest for Executive Functioning, Psychomotor Speed, Memory (26.5%, 23.2%, 19.3%, respectively). Patients high-grade more severely than low-grade glioma. Tumor volume, isocitrate dehydrogenase status, WHO grade, histology domain-specific impairments.Cognitive impairment occurs majority treatment-naive are involved most frequently. These explained not only by location but also other (biological) mechanisms.

Язык: Английский

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Probing rapid network reorganization of motor and language functions via neuromodulation and neuroimaging

NeuroImage, Год журнала: 2020, Номер 224, С. 117449 - 117449

Опубликована: Окт. 12, 2020

Motor and cognitive functions are organized in large-scale networks the human brain that interact to enable flexible adaptation of information exchange ever-changing environmental conditions. In this review, we discuss unique potential consecutive combination repetitive transcranial magnetic stimulation (rTMS) functional neuroimaging probe network organization reorganization healthy lesioned brain. First, summarize findings highlighting (re-)distribution short-term motor Plastic after-effects rTMS result changes on level affecting both local remote activity within stimulated as well interactions between distinct networks. While number combined rTMS-fMRI studies patients with lesions remains scarce, preliminary evidence suggests flexibly (re-)distributes its computational capacities functionally reorganize impaired functions, using a similar set mechanisms achieve adaptive plasticity compared observed after rTMS. general, stroke-induced seem rely three general allow maintain recover function: i) interhemispheric changes, including increased contribution homologous regions contralateral hemisphere connectivity, ii) differentially specialized iii) contributions domain-general disruption more specific functions. These may for flexibility neural underlying Future should use complementary approaches address relevance further delineate how these flexibility. Besides furthering our neurophysiological insights into interactions, identifying support enhance clinically relevant diagnostic treatment approaches.

Язык: Английский

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Lateralization, functional specialization, and dysfunction of attentional networks

Cortex, Год журнала: 2020, Номер 132, С. 206 - 222

Опубликована: Сен. 11, 2020

Язык: Английский

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The hidden repertoire of brain dynamics and dysfunction

Network Neuroscience, Год журнала: 2019, Номер 3(4), С. 994 - 1008

Опубликована: Янв. 1, 2019

The purpose of this paper is to describe a framework for the understanding rules that govern how neural system dynamics are coordinated produce behavior. framework, structured flows on manifolds (SFM), posits processes depicting interactions occur relatively low-dimension manifolds, which constrain possible functional configurations. Although general we focus application brain disorders. We first explain Epileptor, phenomenological computational model showing fast and slow dynamics, but also hidden repertoire whose expression similar refractory status epilepticus. suggest epilepsy represents an innate state potential may be realized only under certain circumstances. Conversely, deficits from damage or disease processes, such as stroke dementia, reflect both process per se adaptation brain. SFM uniquely captures scenarios. Finally, link neuromodulation effects switches in network configurations coordinate context cognition. tools measure already exist, giving researchers access support concomitant cognitive behavioral processes.

Язык: Английский

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Predicting the Response to Non-invasive Brain Stimulation in Stroke

Frontiers in Neurology, Год журнала: 2019, Номер 10

Опубликована: Апрель 2, 2019

OPINION article Front. Neurol., 02 April 2019Sec. Stroke Volume 10 - 2019 | https://doi.org/10.3389/fneur.2019.00302

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Edge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery

NeuroImage Clinical, Год журнала: 2022, Номер 35, С. 103055 - 103055

Опубликована: Янв. 1, 2022

Most neuroimaging studies of post-stroke recovery rely on analyses derived from standard node-centric functional connectivity to map the distributed effects in stroke patients. Here, given importance nonlocal and diffuse damage, we use an edge-centric approach order provide alternative description this disorder. These techniques allow for rendering metrics such as normalized entropy, which describes diversity edge communities at each node. Moreover, enables identification high amplitude co-fluctuations fMRI time series. We found that entropy is associated with lesion severity continually increases across patients' recovery. Furthermore, not only relate but are also level The current study first application a clinical population longitudinal dataset demonstrates how different perspective data analysis can further characterize topographic modulations brain dynamics.

Язык: Английский

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Evidence that robot-assisted gait training modulates neuroplasticity after stroke: An fMRI pilot study based on graph theory analysis

Brain Research, Год журнала: 2024, Номер 1842, С. 149113 - 149113

Опубликована: Июль 5, 2024

Язык: Английский

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Generative whole-brain dynamics models from healthy subjects predict functional alterations in stroke at the level of individual patients

Brain Communications, Год журнала: 2024, Номер 6(4)

Опубликована: Янв. 1, 2024

Abstract Computational whole-brain models describe the resting activity of each brain region based on a local model, inter-regional functional interactions, and structural connectome that specifies strength connections. Strokes damage healthy forms backbone these produce large alterations in interactions. These interactions are typically measured by correlating time series between two regions process, called connectivity. We show adding information about disconnections produced patient’s lesion to model previously trained data from cohort subjects enables prediction connectivity patient fits directly (Pearson correlation = 0.37; mean square error 0.005). Furthermore, dynamics reproduce connectivity-based measures abnormal stroke patients specifically isolate abnormalities. Therefore, although involve number free parameters, results that, even after fixing those reproduces population very different than which was trained. In addition validating mechanistically captures relationships anatomical structure human brain.

Язык: Английский

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Neurocognitive changes after awake surgery in glioma patients: a retrospective cohort study

Journal of Neuro-Oncology, Год журнала: 2019, Номер 146(1), С. 97 - 109

Опубликована: Дек. 4, 2019

Abstract Purpose Deficits in neurocognitive functioning (NCF) frequently occur glioma patients. Both treatment and the tumor itself contribute to these deficits. In order minimize harmful effects of surgery, an increasing number patients undergo awake craniotomy. To investigate whether we can indeed preserve cognitive after state-of-the art surgery identify factors determining postoperative NCF, performed a retrospective cohort study. Methods diffuse (WHO grade 2–4) undergoing craniotomy, studied both pre-operatively 3–6 months postoperatively. Evaluation covered five domains. We analysis data on group individual level evaluated value patient-, tumor- treatment-related for predicting change using linear logistic regression analysis. Results included 168 consecutive Mean NCF-scores psychomotor speed visuospatial significantly deteriorated surgery. The percentage serious impairments (− 2 standard deviations) increased only. Tumor involvement left thalamus predicted decline NCF domains overall-NCF, executive speed. An IDH-wildtype status overall-NCF functioning. Conclusions all domains, except speed, be preserved domain seems most vulnerable early therapies. Cognitive performance is associated with combination structural biomolecular from tumor, including IDH-status thalamic involvement.

Язык: Английский

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