Fabrication of PVTF Electroactive Coatings on PEEK Implant to Provide Surface Potential for Enhancing Osteogenesis

Coatings, Год журнала: 2025, Номер 15(3), С. 261 - 261

Опубликована: Фев. 22, 2025

Polyetheretherketone (PEEK) has gained significant attention in biomedical applications due to its excellent mechanical properties and biocompatibility. In this work, the fabrication of electroactive poly(vinylidenefluoride-co-trifluoroethylene) (PVTF) coatings on PEEK surfaces enhance osteogenesis is explored. substrates were prepared with different surface treatments optimize adhesion, followed by PVTF coating through drop-casting polarization. Morphological, chemical, thermal characterizations revealed uniform β-phase crystallization layer, achieving a peak piezoelectric coefficient (d33) 16 pC/N under 4 kV polarization voltage. Cell culture experiments demonstrated improved biocompatibility, polarized showing enhanced bone marrow mesenchymal stem cell (BMSC) proliferation, osteogenic differentiation. ALP activity, key marker osteogenesis, was significantly higher samples. Furthermore, modified exhibited strong adhesion between PEEK, as well sustained potential physiological conditions. These test results indicate that PEEK/PVTF composite, shows great an material for implants.

Язык: Английский

Piezoelectric Biomaterials for Use in Bone Tissue Engineering—A Narrative Review

Journal of Biomedical Materials Research Part B Applied Biomaterials, Год журнала: 2025, Номер 113(4)

Опубликована: Март 17, 2025

ABSTRACT To examine natural bone's bioelectrical traits, notably its piezoelectricity, and to look into how these characteristics influence bone growth repair. In the context of exploring potential piezoelectric biomaterials, such as biopolymers bio‐ceramics, towards orthopedic regeneration applications, research seeks evaluate significance piezoelectricity‐driven osteogenesis. The paper reviews recent on electrical dielectric properties, surface polarization/electrical stimulation effects interacting with cell activity effectiveness biomaterials support tissues' regenerative process. study includes a number materials, collagen, polyvinylidene fluoride (PVDF) barium titanate. applications organic polymers, polymers are particularly highlighted. Piezoelectric being shown in studies enhance cellular metabolism vitro well promote tissues vivo, especially when paired electric field or interface polarization. bio‐ceramics like magnesium silicate titanate, collagen PVDF, have possibilities for applications. However, there several challenges regarding manufacturing specific compositions having desired properties. This review highlighted special emphasis bioceramics. Therefore, types materials huge because they can mimic properties allow better advances tissue engineering medicine. date, little is known about their mechanism action, modifications needed improve efficacy clinical uptake.

Язык: Английский