MGAT4EP promotes tumor progression and serves as a prognostic marker for breast cancer
Cancer Biology & Therapy,
Год журнала:
2025,
Номер
26(1)
Опубликована: Март 11, 2025
Breast
cancer
remains
a
global
health
challenge
with
varied
prognoses
despite
treatment
advancements.
Therefore,
this
study
explores
the
pseudogene
MGAT4EP
as
potential
biomarker
and
therapeutic
target
in
breast
cancer.
Using
TCGA
data
bioinformatics,
was
identified
significantly
overexpressed
tissues
associated
poor
prognosis.
Multivariate
Cox
regression
confirmed
important
prognostic
factor.
A
clinical
prediction
model
based
on
expression
showed
high
accuracy
for
1-,
3-,
5-year
survival
rates
translated
into
nomogram
application.
Functional
studies
revealed
that
silencing
via
siRNA
promoted
apoptosis,
inhibited
migration
invasion
cells.
RNA-seq,
GSEA,
GO
analyses
linked
to
apoptosis
focal
adhesion
pathways.
Notably,
knock
down
of
suppressed
tumor
growth
metastasis
xenograft
lung
models.
Taken
together,
these
findings
establish
an
attractive
metastatic
provide
promising
treatment.
Язык: Английский
Glucagon-like peptide 1 receptor agonists and cancer risk: advancing precision medicine through mechanistic understanding and clinical evidence
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Март 27, 2025
Abstract
Glucagon-like
peptide-1
receptor
agonists
(GLP-1RAs)
have
emerged
as
a
primary
first-line
treatment
for
type
2
diabetes.
This
has
raised
concerns
about
their
impact
on
cancer
risk,
spurring
extensive
research.
review
systematically
examines
the
varied
effects
of
GLP-1RAs
risk
different
types
tumors,
including
overall
and
specific
cancers
such
thyroid,
pancreatic,
reproductive
system,
liver,
colorectal
cancers.
The
potential
biological
mechanisms
underlying
influence
are
complex,
involving
metabolic
regulation,
direct
antitumor
effects,
immune
modulation,
epigenetic
changes.
A
systematic
comparison
with
other
antidiabetic
agents
reveals
notable
differences
in
across
drug
classes.
Additionally,
critical
factors
that
shape
relationship
between
thoroughly
analyzed,
patient
demographics,
comorbidities,
regimens,
lifestyle
factors,
offering
essential
insights
developing
individualized
protocols.
Despite
significant
research
progress,
gaps
remain.
Future
should
prioritize
elucidating
molecular
behind
refining
strategies,
investigating
early
tumor
prevention
applications,
assessing
benefits
non-diabetic
populations,
advancing
development
novel
therapies,
establishing
robust
safety
monitoring
frameworks,
building
precision
medicine
decision-making
platforms.
These
efforts
aim
to
establish
roles
prevention.
treatment,
thereby
progress
medicine.
Язык: Английский
Single-cell data and network pharmacology screen hub genes related to oxidative stress response in myeloid cell of osteoarthritis
Current Pharmaceutical Analysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Identification of Potential Therapeutic Targets for Stroke Using Data Mining, Network Analysis, Enrichment, and Docking Analysis
Computational Biology and Chemistry,
Год журнала:
2025,
Номер
unknown, С. 108431 - 108431
Опубликована: Март 1, 2025
Язык: Английский
Chaigui Bitong decoction inhibits rheumatoid arthritis fibroblast-like synoviocyte injury through regulating the ferroptosis signaling pathway via Nrf2/HO-1/GPX4 axis
Current Pharmaceutical Analysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
P
Natural
killer
(NK)
cells
function
as
crucial
effectors
in
the
innate
immune
response
against
tumors.
Nevertheless,
NK
cell
senescence,
characterized
by
phenotypic
and
functional
changes,
substantially
compromises
their
antitumor
response.
This
review
provides
a
comprehensive
summary
of
molecular
mechanisms
governing
senescence
its
implications
for
cancer
immunotherapy.
We
propose
refined
definition
based
on
distinct
biomarkers,
including
elevated
CD57
expression,
reduced
cytotoxicity,
altered
cytokine
secretion.
Moreover,
we
investigate
complex
interactions
between
tumor
microenvironment
(TME)
highlighting
influence
chronic
inflammation,
immunosuppressive
cytokines,
persistent
antigenic
stimulation.
Additionally,
this
underscores
potential
utility
senescent
biomarkers
assessing
efficacy
examines
adverse
effects
Lastly,
summarize
current
approaches
to
mitigate
such
gene
editing
techniques
modulation,
which
may
enhance
cell-based
immunotherapies.
By
establishing
framework
understanding
within
TME,
aims
guide
future
research
development
innovative
therapeutic
strategies
targeting
improve
immunotherapy
outcomes.
Язык: Английский