The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

Pharmacological Research, Год журнала: 2021, Номер 172, С. 105840 - 105840

Опубликована: Авг. 24, 2021

Emerging evidence indicates that the gut microbiota play a crucial role in bidirectional communication between and brain suggesting microbes may shape neural development, modulate neurotransmission affect behavior, thereby contribute to pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, neurological conditions. This review summarizes recent data on microbiota-gut-brain axis pathophysiology neuropsychiatric disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, epilepsy. Also, involvement co-existing with conditions is highlighted. We discuss from both vivo preclinical experiments clinical reports including: (1) studies germ-free animals, (2) exploring composition animal models diseases or humans, (3) evaluating effects probiotic, prebiotic antibiotic treatment as well (4) fecal transplantation.

Язык: Английский

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Perturbations in Gut Microbiota Composition in Psychiatric Disorders

JAMA Psychiatry, Год журнала: 2021, Номер 78(12), С. 1343 - 1343

Опубликована: Сен. 15, 2021

Evidence of gut microbiota perturbations has accumulated for multiple psychiatric disorders, with signatures proposed as potential biomarkers. However, no attempts have been made to evaluate the specificity these across range conditions.

Язык: Английский

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A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1920 - 1935

Опубликована: Фев. 22, 2022

Abstract The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects physiology has gained substantial attention in the field psychiatry. This is largely due to overlapping pathophysiological mechanisms associated with both potential functionality and biological thought be underpinning mental disorders. In this systematic review, we synthesised current literature investigating differences composition people major psychiatric disorders, depressive disorder (MDD), bipolar (BD) schizophrenia (SZ), compared ‘healthy’ controls. We also explored across disorders an attempt elucidate commonalities microbial signatures these Following PRISMA guidelines, databases were searched from inception through December 2021. identified 44 studies (including a total 2510 cases 2407 controls) that met inclusion criteria, which 24 investigated MDD, seven BD, 15 SZ. Our syntheses provide no strong evidence for difference number or distribution (α-diversity) bacteria those However, relatively consistent reporting overall community (β-diversity) without specific bacterial taxa commonly including lower levels genera produce short-chain fatty acids (e.g. butyrate), higher lactic acid-producing bacteria, glutamate GABA metabolism. observed heterogeneity regards methodologies reporting. Further prospective experimental research using new tools robust guidelines hold promise improving our role brain health development interventions based on modification microbiota.

Язык: Английский

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Gut microbiota and its metabolites in depression: from pathogenesis to treatment

EBioMedicine, Год журнала: 2023, Номер 90, С. 104527 - 104527

Опубликована: Март 22, 2023

Язык: Английский

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Brain–gut–microbiota axis in depression: A historical overview and future directions

Brain Research Bulletin, Год журнала: 2022, Номер 182, С. 44 - 56

Опубликована: Фев. 11, 2022

Depression is the most common mental disorder and a leading cause of disability worldwide. Despite abundant research, precise mechanisms underlying pathophysiology depression remain elusive. Accumulating evidence from preclinical clinical studies suggests that alterations in gut microbiota, microbe-derived short-chain fatty acids, D-amino acids metabolites play key role via brain–gut–microbiota axis, including neural immune systems. Notably, axis might crucial susceptibility versus resilience rodents exposed to stress. Vagotomy reported block depression-like phenotypes after fecal microbiota transplantation "depression-related" microbiome, suggesting vagus nerve influences through axis. In this article, we review recent findings regarding discuss its potential as therapeutic target for depression.

Язык: Английский

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Gut microbiome-wide association study of depressive symptoms

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Дек. 6, 2022

Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There an urgency identify molecular and biological mechanisms underlying depression gut microbiome a novel area interest. Here we investigate relation fecal diversity composition with depressive symptoms in 1,054 participants from Rotterdam Study cohort validate these findings Amsterdam HELIUS 1,539 subjects. We association thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum Ruminococcusgauvreauiigroup, family symptoms. These bacteria are known be involved synthesis glutamate, butyrate, serotonin gamma amino butyric acid (GABA), which key neurotransmitters for depression. Our study suggests that may play role

Язык: Английский

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Microbiota alterations in proline metabolism impact depression

Cell Metabolism, Год журнала: 2022, Номер 34(5), С. 681 - 701.e10

Опубликована: Май 1, 2022

The microbiota-gut-brain axis has emerged as a novel target in depression, disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied multi-omics approach combining pre-clinical models three human cohorts including patients mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to High proline consumption was dietary factor strongest impact Whole-brain dynamics revealed rich club network disruptions associated circulating proline. Proline supplementation mice exacerbated along microbial translocation. Human microbiota transplantation induced an emotionally impaired phenotype alterations GABA-, proline-, extracellular matrix-related prefrontal cortex genes. RNAi-mediated knockdown of GABA transporters Drosophila mono-association L. plantarum, high producer, conferred protection against depression-like states. Targeting may open new windows for efficient treatment.

Язык: Английский

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Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression

Molecular Psychiatry, Год журнала: 2022, Номер 27(10), С. 4123 - 4135

Опубликована: Апрель 20, 2022

Язык: Английский

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The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4494 - 4494

Опубликована: Апрель 19, 2022

An emerging body of literature demonstrates differences in the gut microbiome (GMB) patients with major depressive disorder (MDD) compared to healthy controls (HC), as well potential benefits prebiotic, probiotic, and synbiotic treatment. We conducted a systematic review 24 observational studies (n = 2817), 19 interventional trials 1119). assessed alpha diversity, beta taxa abundance changes MDD relative HC, effect prebiotics, probiotics, synbiotics on symptoms individuals clinical or subclinical depression. observed no significant diversity but difference between HC. There were fluctuations specific Probiotic synbiotic, not treatment showed modest benefit reducing over four nine weeks. The GMB profiles differ significantly from further are needed elucidate probiotic treatments antidepressants longer follow-up before these therapies implemented into practice.

Язык: Английский

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Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 125, С. 698 - 761

Опубликована: Март 5, 2021

There is increasing knowledge regarding the role of microbiome in modulating brain and behaviour. Indeed, actions microbial metabolites are key for appropriate gut-brain communication humans. Among these metabolites, short-chain fatty acids, tryptophan, bile acid metabolites/pathways show strong preclinical evidence involvement various aspects function With identification neuroactive modules, new predictive tools can be applied to existing datasets. We identified 278 studies relating human microbiota-gut-brain axis which included sequencing data. This spanned across psychiatric neurological disorders with a small number also focused on normal behavioural development. consistent bioinformatics pipeline, thirty-five datasets were reanalysed from publicly available raw files remainder summarised collated. studies, we uncovered disease-related alterations metabolic pathways Alzheimer's Disease, schizophrenia, anxiety depression. Amongst that could not reanalysed, many technical limitations hindered discovery specific biomarkers microbes or conserved studies. Future warranted confirm our findings. propose guidelines future analysis increase reproducibility consistency within field.

Язык: Английский

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